Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma
Zhuang, Junling, Shirazi, Fazal, Singh, Ram Kumar, Kuiatse, Isere, Wang, Hua, Lee, Hans C., Berkova, Zuzana, Berger, Allison, Hyer, Marc, Chattopadhyay, Nibedita, Syed, Sakeena, Shi, Judy Qiuju, Yu, Jie, Shinde, Vaishali, Tirrell, Stephen, Jones, Richard Julian, Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.
Published in Blood (04.04.2019)
Published in Blood (04.04.2019)
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Journal Article
Biofilm Filtrates of Pseudomonas aeruginosa Strains Isolated from Cystic Fibrosis Patients Inhibit Preformed Aspergillus fumigatus Biofilms via Apoptosis
Shirazi, Fazal, Ferreira, Jose A G, Stevens, David A, Clemons, Karl V, Kontoyiannis, Dimitrios P
Published in PloS one (01.03.2016)
Published in PloS one (01.03.2016)
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Journal Article
The novel protein homeostatic modulator BTX306 is active in myeloma and overcomes bortezomib and lenalidomide resistance
Zou, Jianxuan, Jones, Richard J., Wang, Hua, Kuiatse, Isere, Shirazi, Fazal, Manasanch, Elisabet E., Lee, Hans C., Sullivan, Robert, Fung, Leah, Richard, Normand, Erdman, Paul, Torres, Eduardo, Hecht, David, Lam, Imelda, McElwee, Brooke, Chourasia, Aparajita H., Chan, Kyle W. H., Mercurio, Frank, Stirling, David I., Orlowski, Robert Z.
Published in Journal of molecular medicine (Berlin, Germany) (01.08.2020)
Published in Journal of molecular medicine (Berlin, Germany) (01.08.2020)
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Journal Article
Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors
Jones, Richard J, Singh, Ram K, Shirazi, Fazal, Wan, Jie, Wang, Hua, Wang, Xiaobin, Ha, Min Jin, Baljevic, Muhamed, Kuiatse, Isere, Davis, Richard E, Orlowski, Robert Z
Published in Frontiers in immunology (13.08.2020)
Published in Frontiers in immunology (13.08.2020)
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Journal Article
An antimicrobial peptidomimetic induces Mucorales cell death through mitochondria-mediated apoptosis
Barbu, E Magda, Shirazi, Fazal, McGrath, Danielle M, Albert, Nathaniel, Sidman, Richard L, Pasqualini, Renata, Arap, Wadih, Kontoyiannis, Dimitrios P
Published in PloS one (03.10.2013)
Published in PloS one (03.10.2013)
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Journal Article
Hyperthermia Sensitizes Rhizopus oryzae to Posaconazole and Itraconazole Action through Apoptosis
SHIRAZI, Fazal, PONTIKOS, Michael A, WALSH, Thomas J, ALBERT, Nathaniel, LEWIS, Russell E, KONTOYIANNIS, Dimitrios P
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
Published in Antimicrobial Agents and Chemotherapy (01.09.2013)
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Journal Article
Synthesis and antimicrobial activity of novel oxysterols from lanosterol
Shingate, Bapurao B., Hazra, Braja G., Salunke, Deepak B., Pore, Vandana S., Shirazi, Fazal, Deshpande, Mukund V.
Published in Tetrahedron (01.12.2013)
Published in Tetrahedron (01.12.2013)
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Journal Article
Activating KRAS, NRAS, and BRAF mutants enhance proteasome capacity and reduce endoplasmic reticulum stress in multiple myeloma
Shirazi, Fazal, Jones, Richard J., Singh, Ram K., Zou, Jianxuan, Kuiatse, Isere, Berkova, Zuzana, Wang, Hua, Lee, Hans C., Hong, Samuel, Dick, Larry, Chattopadhyay, Nibedita, Orlowski, Robert Z.
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (18.08.2020)
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Journal Article
Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma
Zhang, Xiaohui, Lee, Hans C., Shirazi, Fazal, Baladandayuthapani, Veerabhadran, Lin, Heather, Kuiatse, Isere, Wang, Hua, Jones, Richard J., Berkova, Zuzana, Singh, Ram Kumar, Lu, Jing, Qian, Yimin, Raina, Kanak, Coleman, Kevin G., Crews, Craig M., Li, Bingzong, Wang, Huihan, Hailemichael, Yared, Thomas, Sheeba K., Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.
Published in Leukemia (01.10.2018)
Published in Leukemia (01.10.2018)
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Journal Article
Mucin 20 modulates proteasome capacity through c‐Met signalling to increase carfilzomib sensitivity in mantle cell lymphoma
Wang, Xiaobin, Shirazi, Fazal, Yan, Wei, Liu, Xiaoyu, Wang, Hua, Orlowski, Robert Z., Wang, Huihan
Published in Journal of cellular and molecular medicine (01.11.2021)
Published in Journal of cellular and molecular medicine (01.11.2021)
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Journal Article
The Anti-B-Cell Maturation Antigen (BCMA) Antibody-α-Amanitin Conjugate Hdp-101 Induces Immunogenic Cell Death and Immunologic Memory in Models of Multiple Myeloma
Singh, Ram Kumar, Jones, Richard J., Shirazi, Fazal M., Zou, Jianxuan M., Wang, Hua, Lee, Hans C., Manasanch, Elisabet E., Kuiatse, Isere, Pahl, Andreas, Orlowski, Robert Z.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
HDP101, a Novel B-Cell Maturation Antigen (BCMA)-Targeted Antibody Conjugated to α-Amanitin, Is Active Against Myeloma with Preferential Efficacy Against Pre-Clinical Models of Deletion 17p
Singh, Ram Kumar, Jones, Richard J., Hong, Samuel, Shirazi, Fazal, Wang, Hua, Kuiatse, Isere, Pahl, Andreas, Orlowski, Robert Z.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Statin Concentrations Below the Minimum Inhibitory Concentration Attenuate the Virulence of Rhizopus oryzae
Bellanger, Anne-Pauline, Tatara, Alexander M., Shirazi, Fazal, Gebremariam, Teclegiorgis, Albert, Nathaniel D., Lewis, Russell E., Ibrahim, Ashraf S., Kontoyiannis, Dimitrios P.
Published in The Journal of infectious diseases (01.07.2016)
Published in The Journal of infectious diseases (01.07.2016)
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Journal Article
Activating KRAS, NRAS, and BRAF Mutants Enhance Proteasome Capacity and Reduce Endoplasmic Reticulum Stress in Multiple Myeloma, Thereby Promoting Plasma Cell Survival and Proteasome Inhibitor Resistance
Shirazi, Fazal, Jones, Richard J., Kuiatse, Isere, Berkova, Zuzana, Wang, Hua, Lee, Hans C., Hong, Samuel, Singh, Ram Kumar, Dick, Lawrence Robert, Chattopadhyay, Nibedita, Orlowski, Robert Z.
Published in Blood (29.11.2018)
Published in Blood (29.11.2018)
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Journal Article
Targeting Myddosome Signaling in Waldenström's Macroglobulinemia with the Interleukin-1 Receptor-Associated Kinase 1/4 Inhibitor R191
Ni, Haiwen, Shirazi, Fazal, Baladandayuthapani, Veerabhadran, Lin, Heather, Kuiatse, Isere, Wang, Hua, Jones, Richard J, Berkova, Zuzana, Hitoshi, Yasumichi, Ansell, Stephen M, Treon, Steven P, Thomas, Sheeba K, Lee, Hans C, Wang, Zhiqiang, Davis, R Eric, Orlowski, Robert Z
Published in Clinical cancer research (15.12.2018)
Published in Clinical cancer research (15.12.2018)
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