Discovery and structural characterization of peficitinib (ASP015K) as a novel and potent JAK inhibitor
Hamaguchi, Hisao, Amano, Yasushi, Moritomo, Ayako, Shirakami, Shohei, Nakajima, Yutaka, Nakai, Kazuo, Nomura, Naoko, Ito, Misato, Higashi, Yasuyuki, Inoue, Takayuki
Published in Bioorganic & medicinal chemistry (01.10.2018)
Published in Bioorganic & medicinal chemistry (01.10.2018)
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Journal Article
A novel JAK inhibitor, peficitinib, demonstrates potent efficacy in a rat adjuvant-induced arthritis model
Ito, Misato, Yamazaki, Shunji, Yamagami, Kaoru, Kuno, Masako, Morita, Yoshiaki, Okuma, Kenji, Nakamura, Koji, Chida, Noboru, Inami, Masamichi, Inoue, Takayuki, Shirakami, Shohei, Higashi, Yasuyuki
Published in Journal of pharmacological sciences (01.01.2017)
Published in Journal of pharmacological sciences (01.01.2017)
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Journal Article
Synthesis and Evaluation of 1H-Pyrrolo[2,3-b]pyridine Derivatives as Novel Immunomodulators Targeting Janus Kinase 3
Nakajima, Yutaka, Tojo, Takashi, Morita, Masataka, Hatanaka, Keiko, Shirakami, Shohei, Tanaka, Akira, Sasaki, Hiroshi, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Takahashi, Fumie, Moritomo, Ayako, Higashi, Yasuyuki, Inoue, Takayuki
Published in Chemical & pharmaceutical bulletin (01.05.2015)
Published in Chemical & pharmaceutical bulletin (01.05.2015)
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Journal Article
Spongipyran synthetic studies. Evolution of a scalable total synthesis of (+)-spongistatin 1
Smith, Amos B., Sfouggatakis, Chris, Risatti, Christina A., Sperry, Jeffrey B., Zhu, Wenyu, Doughty, Victoria A., Tomioka, Takashi, Gotchev, Dimitar B., Bennett, Clay S., Sakamoto, Satoshi, Atasoylu, Onur, Shirakami, Shohei, Bauer, David, Takeuchi, Makoto, Koyanagi, Jyunichi, Sakamoto, Yasuharu
Published in Tetrahedron (15.09.2009)
Published in Tetrahedron (15.09.2009)
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Journal Article
Chirality sensing of saccharides using a boronic acid-appended chiral ferrocene derivative
Takeuchi, Masayuki, Mizuno, Toshihisa, Shinkai, Seiji, Shirakami, Shohei, Itoh, Toshiyuki
Published in Tetrahedron: asymmetry (25.08.2000)
Published in Tetrahedron: asymmetry (25.08.2000)
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Journal Article
AS2553627, a novel JAK inhibitor, prevents chronic rejection in rat cardiac allografts
Nakamura, Koji, Inami, Masamichi, Morio, Hiroki, Okuma, Kenji, Ito, Misato, Noto, Takahisa, Shirakami, Shohei, Hirose, Jun, Morokata, Tatsuaki
Published in European journal of pharmacology (05.02.2017)
Published in European journal of pharmacology (05.02.2017)
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Journal Article
Design, synthesis, and biological evaluation of novel biphenyl-4-carboxamide derivatives as orally available TRPV1 antagonists
Oka, Hiromasa, Yonezawa, Koichi, Kamikawa, Akio, Ikegai, Kazuhiro, Asai, Norio, Shirakami, Shohei, Miyamoto, Satoshi, Watanabe, Toshihiro, Kiso, Tetsuo, Takemoto, Yukihiro, Tamura, Seiji, Kuramochi, Takahiro
Published in Bioorganic & medicinal chemistry (23.07.2018)
Published in Bioorganic & medicinal chemistry (23.07.2018)
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Journal Article
Discovery of 3,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2(1H)-one derivatives as novel JAK inhibitors
Yamagishi, Hiroaki, Shirakami, Shohei, Nakajima, Yutaka, Tanaka, Akira, Takahashi, Fumie, Hamaguchi, Hisao, Hatanaka, Keiko, Moritomo, Ayako, Inami, Masamichi, Higashi, Yasuyuki, Inoue, Takayuki
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
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Journal Article
Design, synthesis, and evaluation of 4,6-diaminonicotinamide derivatives as novel and potent immunomodulators targeting JAK3
Nakajima, Yutaka, Aoyama, Naohiro, Takahashi, Fumie, Sasaki, Hiroshi, Hatanaka, Keiko, Moritomo, Ayako, Inami, Masamichi, Ito, Misato, Nakamura, Koji, Nakamori, Fumihiro, Inoue, Takayuki, Shirakami, Shohei
Published in Bioorganic & medicinal chemistry (01.10.2016)
Published in Bioorganic & medicinal chemistry (01.10.2016)
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Journal Article
Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3
Nakajima, Yutaka, Inoue, Takayuki, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Hatanaka, Keiko, Sasaki, Hiroshi, Tanaka, Akira, Takahashi, Fumie, Kunikawa, Shigeki, Usuda, Hiroyuki, Moritomo, Ayako, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei
Published in Bioorganic & medicinal chemistry (01.08.2015)
Published in Bioorganic & medicinal chemistry (01.08.2015)
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Journal Article
Discovery of tricyclic dipyrrolopyridine derivatives as novel JAK inhibitors
Yamagishi, Hiroaki, Inoue, Takayuki, Nakajima, Yutaka, Maeda, Jun, Tominaga, Hiroaki, Usuda, Hiroyuki, Hondo, Takeshi, Moritomo, Ayako, Nakamori, Fumihiro, Ito, Misato, Nakamura, Koji, Morio, Hiroki, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei
Published in Bioorganic & medicinal chemistry (15.10.2017)
Published in Bioorganic & medicinal chemistry (15.10.2017)
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Journal Article
Corrigendum to “Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3” [Bioorg. Med. Chem. 23 (2015) 4871–4883]
Nakajima, Yutaka, Inoue, Takayuki, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Hatanaka, Keiko, Sasaki, Hiroshi, Tanaka, Akira, Takahashi, Fumie, Kunikawa, Shigeki, Usuda, Hiroyuki, Moritomo, Ayako, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei
Published in Bioorganic & medicinal chemistry (15.05.2017)
Published in Bioorganic & medicinal chemistry (15.05.2017)
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Journal Article
Corrigendum to “Synthesis and evaluation of novel 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives as potent and orally efficacious immunomodulators targeting JAK3” [Bioorg. Med. Chem. 23 (2015) 4871–4883]
Nakajima, Yutaka, Inoue, Takayuki, Nakai, Kazuo, Mukoyoshi, Koichiro, Hamaguchi, Hisao, Hatanaka, Keiko, Sasaki, Hiroshi, Tanaka, Akira, Takahashi, Fumie, Kunikawa, Shigeki, Usuda, Hiroyuki, Moritomo, Ayako, Higashi, Yasuyuki, Inami, Masamichi, Shirakami, Shohei
Published in Bioorganic & medicinal chemistry (15.09.2016)
Published in Bioorganic & medicinal chemistry (15.09.2016)
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Journal Article
Total Synthesis of (+)-Spongistatin 1. An Effective Second-Generation Construction of an Advanced EF Wittig Salt, Fragment Union, and Final Elaboration
Smith, Amos B, Zhu, Wenyu, Shirakami, Shohei, Sfouggatakis, Chris, Doughty, Victoria A, Bennett, Clay S, Sakamoto, Yasuharu
Published in Organic letters (06.03.2003)
Published in Organic letters (06.03.2003)
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Journal Article
NITROGENATEDBICYCLIC AROMATIC HETEROCYCLIC COMPOUND
SATO JUNJI, AOYAMA NAOHIRO, NAKAJIMA YUTAKA, IMADA SUNAO, NAKANISHI KEITA, NIGAWARA TAKAHIRO, SHIRAI FUMIYUKI, SHIRAKAMI SHOHEI, KUBO KAORI, TAKASUNA YUJI
Year of Publication 22.12.2014
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Year of Publication 22.12.2014
Patent
Spongistatin Synthetic Studies. Evolution of a Scalable Synthesis for the EF Fragment of (+)-Spongistatin 1 Exploiting a Petasis−Ferrier Union/Rearrangement Tactic
Smith, Amos B, Sfouggatakis, Chris, Gotchev, Dimitar B, Shirakami, Shohei, Bauer, David, Zhu, Wenyu, Doughty, Victoria A
Published in Organic letters (30.09.2004)
Published in Organic letters (30.09.2004)
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Journal Article
Spongipyran synthetic studies. Evolution of a scalable total synthesis of (+)-spongistatin 1: 2008 Tetrahedron Prize for Creativity in Organic Chemistry. The Art of Synthesis: Methods, Strategies and Applications
SMITH, Amos B, SFOUGGATAKIS, Chris, ATASOYLU, Onur, SHIRAKAMI, Shohei, BAUER, David, TAKEUCHI, Makoto, KOYANAGI, Jyunichi, SAKAMOTO, Yasuharu, RISATTI, Christina A, SPERRY, Jeffrey B, WENYU ZHU, DOUGHTY, Victoria A, TOMIOKA, Takashi, GOTCHEV, Dimitar B, BENNETT, Clay S, SAKAMOTO, Satoshi
Published in Tetrahedron (2009)
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Published in Tetrahedron (2009)
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