Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders
Noji, Satoru, Hara, Yoshinori, Miura, Tomoya, Yamanaka, Hiroshi, Maeda, Katsuya, Hori, Akimi, Yamamoto, Hiroshi, Obika, Shingo, Inoue, Masafumi, Hase, Yasunori, Orita, Takuya, Doi, Satoki, Adachi, Tsuyoshi, Tanimoto, Atsuo, Oki, Chika, Kimoto, Yukari, Ogawa, Yoshihiro, Negoro, Tamotsu, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Structure–activity relationship study, target identification, and pharmacological characterization of a small molecular IL-12/23 inhibitor, APY0201
Hayakawa, Nobuhiko, Noguchi, Masatsugu, Takeshita, Sen, Eviryanti, Agung, Seki, Yukie, Nishio, Hikaru, Yokoyama, Ryohei, Noguchi, Misato, Shuto, Manami, Shima, Yoichiro, Kuribayashi, Kanna, Kageyama, Shunsuke, Eda, Hiroyuki, Suzuki, Manabu, Hatta, Tomohisa, Iemura, Shun-ichiro, Natsume, Tohru, Tanabe, Itsuya, Nakagawa, Ryusuke, Shiozaki, Makoto, Sakurai, Kuniya, Shoji, Masataka, Andou, Ayatoshi, Yamamoto, Takashi
Published in Bioorganic & medicinal chemistry (01.06.2014)
Published in Bioorganic & medicinal chemistry (01.06.2014)
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Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors
Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi
Published in Journal of medicinal chemistry (28.04.2011)
Published in Journal of medicinal chemistry (28.04.2011)
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Tu1864 A Novel Orally Active Phosphatidylinositol 3-Phosphate 5-Kinase (Pikfyve) Inhibitor Ameliorates Mouse Colitis by Inhibition of IL-12 and IL-23 Production From Macrophages
Andou, Ayatoshi, Yamamoto, Takashi, Agung, Eviryanti, Seki, Yukie, Nishio, Hikaru, Shuto, Manami, Noguchi, Misato, Shima, Yoichiro, Takeshita, Sen, Yokoyama, Ryohei, Hayakawa, Nobuhiko, Noguchi, Masatsugu, Kageyama, Shunsuke, Eda, Hiroyuki, Shiozaki, Makoto, Tanabe, Itsuya, Nakagawa, Ryusuke, Sakurai, Kuniya, Masataka, Shoji
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors
SHIOZAKI, Makoto, MAEDA, Katsuya, MIMURA, Takayuki, SHINOZAKI, Yuichi, YOSHIUCHI, Hiromi, INABA, Takashi, MIURA, Tomoya, OGOSHI, Yosuke, HAAS, Julia, FRYER, Andrew M, LAIRD, Ellen R, LITTMANN, Nicole M, ANDREWS, Steven W, JOSEY, John A
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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Nuamcharoen, Praewpanit, Kobayashi, Takaomi, Potiyaraj, Pranut, Shiozaki, Makoto
Published in Polymer international (01.08.2020)
Published in Polymer international (01.08.2020)
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Activin A: A Commitment Factor in Erythroid Differentiation
Shiozaki, Makoto, Kosaka, Masaaki, Eto, Yuzuru
Published in Biochemical and biophysical research communications (26.01.1998)
Published in Biochemical and biophysical research communications (26.01.1998)
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Pharmacological properties of JTE-052: a novel potent JAK inhibitor that suppresses various inflammatory responses in vitro and in vivo
Tanimoto, Atsuo, Ogawa, Yoshihiro, Oki, Chika, Kimoto, Yukari, Nozawa, Keisuke, Amano, Wataru, Noji, Satoru, Shiozaki, Makoto, Matsuo, Akira, Shinozaki, Yuichi, Matsushita, Mutsuyoshi
Published in Inflammation research (01.01.2015)
Published in Inflammation research (01.01.2015)
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Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold
Kotoku, Masayuki, Maeba, Takaki, Fujioka, Shingo, Yokota, Masahiro, Seki, Noriyoshi, Ito, Keisuke, Suwa, Yoshihiro, Ikenogami, Taku, Hirata, Kazuyuki, Hase, Yasunori, Katsuda, Yoshiaki, Miyagawa, Naoki, Arita, Kojo, Asahina, Kota, Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Adachi, Tsuyoshi, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Hashimoto, Hiromasa, Suzuki, Takayoshi, Shiozaki, Makoto
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development
Maeba, Takaki, Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeda, Katsuya, Hirashima, Shintaro, Yamanaka, Hiroshi, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hara, Yoshinori, Noji, Satoru, Suwa, Yoshihiro, Yokota, Masahiro, Fujioka, Shingo, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Taniguchi, Toshio, Asahina, Kota, Aratsu, Yusuke, Naka, Yuichi, Adachi, Tsuyoshi, Nomura, Akihiro, Akai, Shota, Oshida, Shin-ichi, Pai, Sudhakar, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Soeta, Takahiro, Ukaji, Yutaka, Shiozaki, Makoto
Published in Journal of medicinal chemistry (25.01.2024)
Published in Journal of medicinal chemistry (25.01.2024)
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Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction
Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Maeda, Katsuya, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Adachi, Tsuyoshi
Published in Scientific reports (26.11.2018)
Published in Scientific reports (26.11.2018)
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NITROGEN-CONTAINING SPIROCYCLIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF
SHIOZAKI MAKOTO, MIURA TOMOYA, YAMANAKA HIROSHI, MAEDA KATSUYA, INOUE AKIFUMI, HARA YOSHINORI, NOMICHI SATORU, HORI AKIMI, HASE YASUNORI
Year of Publication 02.10.2023
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Year of Publication 02.10.2023
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Discovery of Selective Transforming Growth Factor β Type II Receptor Inhibitors as Antifibrosis Agents
Miwa, Shohei, Yokota, Masahiro, Ueyama, Yoshifumi, Maeda, Katsuya, Ogoshi, Yosuke, Seki, Noriyoshi, Ogawa, Naoki, Nishihata, Jun, Nomura, Akihiro, Adachi, Tsuyoshi, Kitao, Yuki, Nozawa, Keisuke, Ishikawa, Tomohiro, Ukaji, Yutaka, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious ROR gamma Inhibitor
Hirata, Kazuyuki, Kotoku, Masayuki, Seki, Noriyoshi, Maeba, Takaki, Maeda, Katsuya, Hirashima, Shintaro, Sakai, Takayuki, Obika, Shingo, Hori, Akimi, Hase, Yasunori, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Hata, Takahiro, Miyagawa, Naoki, Arita, Kojo, Nomura, Yukihiro, Asahina, Kota, Aratsu, Yusuke, Kamada, Masafumi, Adachi, Tsuyoshi, Noguchi, Masato, Doi, Satoki, Crowe, Paul, Bradley, Erin, Steensma, Ruo, Tao, Haiyan, Fenn, Morgan, Babine, Robert, Li, Xiaolin, Thacher, Scott, Hashimoto, Hiromasa, Shiozaki, Makoto
Published in ACS medicinal chemistry letters (14.01.2016)
Published in ACS medicinal chemistry letters (14.01.2016)
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Ternary complex of human ROR[gamma] ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment
Noguchi, Masato, Nomura, Akihiro, Murase, Ken, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Steensma, Ruo, Li, Xioalin, Tao, Haiyan, Tse, Bruno, Fenn, Morgan, Babine, Robert, Bradley, Erin, Crowe, Paul, Thacher, Scott, Adachi, Tsuyoshi, Kamada, Masafumi
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)
Published in Genes to cells : devoted to molecular & cellular mechanisms (01.06.2017)
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