Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent
Saito, Keiji, Shinozuka, Tsuyoshi, Nakao, Akira, Kunikata, Tomonori, Nakai, Daisuke, Nagai, Yoko, Naito, Satoru
Published in Bioorganic & medicinal chemistry letters (15.12.2021)
Published in Bioorganic & medicinal chemistry letters (15.12.2021)
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Synthesis and structure-activity relationship of 4-alkoxy-thieno[2,3-b]pyridine derivatives as potent alkaline phosphatase enhancers for osteoporosis treatment
Saito, Keiji, Shinozuka, Tsuyoshi, Nakao, Akira, Kiho, Toshihiro, Kunikata, Tomonori, Shiiki, Takeshi, Nagai, Yoko, Naito, Satoru
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
Published in Bioorganic & medicinal chemistry letters (15.07.2019)
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Discovery of a Novel Class of State-Dependent NaV1.7 Inhibitors for the Treatment of Neuropathic Pain
Tanaka, Kyosuke, Kobayashi, Hiroyuki, Suzuki, Sayaka, Shibuya, Satoshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Shinozuka, Tsuyoshi
Published in Chemical & pharmaceutical bulletin (01.07.2020)
Published in Chemical & pharmaceutical bulletin (01.07.2020)
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Discovery of a Novel Class of State-Dependent Na(V)1.7 Inhibitors for the Treatment of Neuropathic Pain
Tanaka, Kyosuke, Kobayashi, Hiroyuki, Suzuki, Sayaka, Shibuya, Satoshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Koishi, Ryuta, Fujiwara, Chie, Asano, Daigo, Shinozuka, Tsuyoshi
Published in Chemical & pharmaceutical bulletin (01.07.2020)
Published in Chemical & pharmaceutical bulletin (01.07.2020)
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Structure–Activity Relationship Studies of 3- or 4‑Pyridine Derivatives of DS-6930
Shinozuka, Tsuyoshi, Tsukada, Tomoharu, Fujii, Kunihiko, Tokumaru, Eri, Matsui, Yumi, Wakimoto, Satoko, Ogata, Tsuneaki, Araki, Kazushi, Sawamura, Ryoko, Watanabe, Nobuaki, Mori, Makoto, Tanaka, Jun
Published in ACS medicinal chemistry letters (14.03.2019)
Published in ACS medicinal chemistry letters (14.03.2019)
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Discovery of (phenoxy-2-hydroxypropyl)piperidines as a novel class of voltage-gated sodium channel 1.7 inhibitors
Suzuki, Sayaka, Kuroda, Takeshi, Kimoto, Hiroko, Domon, Yuki, Kubota, Kazufumi, Kitano, Yutaka, Yokoyama, Tomihisa, Shimizugawa, Akiko, Sugita, Ryusuke, Koishi, Ryuta, Asano, Daigo, Tamaki, Kazuhiko, Shinozuka, Tsuyoshi, Kobayashi, Hiroyuki
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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First total synthesis of sterenins A, C and D
Shinozuka, Tsuyoshi, Yamamoto, Yuko, Hasegawa, Toru, Saito, Keiji, Naito, Satoru
Published in Tetrahedron letters (03.03.2008)
Published in Tetrahedron letters (03.03.2008)
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A practical method for the preparation of 4-nitrogen-substituted benzoic acids
Shinozuka, Tsuyoshi, Nakao, Akira, Saito, Keiji, Naito, Satoru
Published in Chemistry letters (05.10.2006)
Published in Chemistry letters (05.10.2006)
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Discovery of a Novel Class of ERRα Agonists
Shinozuka, Tsuyoshi, Ito, Shuichiro, Kimura, Takako, Izumi, Masanori, Wakabayashi, Kenji
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver
Asano, Daigo, Nakamura, Koichi, Nishiya, Yumi, Shiozawa, Hideyuki, Takakusa, Hideo, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Hamada, Takakazu, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.01.2023)
Published in Drug metabolism and disposition (01.01.2023)
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Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase
Asano, Daigo, Shibayama, Takahiro, Shiozawa, Hideyuki, Inoue, Shin-ichi, Shinozuka, Tsuyoshi, Murata, Shinji, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Xenobiotica (02.09.2021)
Published in Xenobiotica (02.09.2021)
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Journal Article
Evaluation of species differences in the metabolism of the selective Na V 1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase
Asano, Daigo, Shibayama, Takahiro, Shiozawa, Hideyuki, Inoue, Shin-ichi, Shinozuka, Tsuyoshi, Murata, Shinji, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Xenobiotica (02.09.2021)
Published in Xenobiotica (02.09.2021)
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CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
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Journal Article
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective Na V 1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate
Asano, Daigo, Hamaue, Syoya, Zahir, Hamim, Shiozawa, Hideyuki, Nishiya, Yumi, Kimura, Takako, Kazui, Miho, Yamamura, Naotoshi, Ikeguchi, Marie, Shibayama, Takahiro, Inoue, Shin-Ichi, Shinozuka, Tsuyoshi, Watanabe, Toshiyuki, Yahara, Chizuko, Watanabe, Nobuaki, Yoshinari, Kouichi
Published in Drug metabolism and disposition (01.03.2022)
Published in Drug metabolism and disposition (01.03.2022)
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