PEG-modification on the endo-position of an antisense oligonucleotide increases tumor accumulation via the EPR effect
Hagiwara, Kenji, Kurihara, Kana, Honma, Masakazu, Yamamoto, Junichiro, Shinohara, Fumikazu
Published in Journal of biomaterials science. Polymer ed. (04.03.2018)
Published in Journal of biomaterials science. Polymer ed. (04.03.2018)
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Structure-guided screening strategy combining surface plasmon resonance with nuclear magnetic resonance for identification of small-molecule Argonaute 2 inhibitors
Harumoto, Toshimasa, Sato, Atsuko, Takayama, Yuki, Miyagi, Hikaru, Saito, Jun-ichi, Shinohara, Fumikazu
Published in PloS one (31.07.2020)
Published in PloS one (31.07.2020)
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siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand
Shinohara, Fumikazu, Oashi, Taiji, Harumoto, Toshimasa, Nishikawa, Tomoyuki, Takayama, Yuki, Miyagi, Hikaru, Takahashi, Yuichi, Nakajima, Takahiro, Sawada, Takashi, Koda, Yasuo, Makino, Asana, Sato, Atsuko, Hamaguchi, Kaori, Suzuki, Michihiko, Yamamoto, Junichiro, Tomari, Yukihide, Saito, Jun-Ichi
Published in RNA (Cambridge) (01.02.2021)
Published in RNA (Cambridge) (01.02.2021)
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Simplifying the Chemical Structure of Cationic Lipids for siRNA-Lipid Nanoparticles
Kuboyama, Takeshi, Yagi, Kaori, Naoi, Tomoyuki, Era, Tomohiro, Yagi, Nobuhiro, Nakasato, Yoshisuke, Yabuuchi, Hayato, Takahashi, Saori, Shinohara, Fumikazu, Iwai, Hiroto, Koubara-Yamada, Ayumi, Hasegawa, Kazumasa, Miwa, Atsushi
Published in ACS medicinal chemistry letters (09.05.2019)
Published in ACS medicinal chemistry letters (09.05.2019)
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Development of Prodrug Type Circular siRNA for In Vivo Knockdown by Systemic Administration
Hagiwara, Kenji, Honma, Masakazu, Harumoto, Toshimasa, Harada, Kenji, Sawada, Takashi, Yamamoto, Junichiro, Shinohara, Fumikazu
Published in Nucleic acid therapeutics (01.12.2020)
Published in Nucleic acid therapeutics (01.12.2020)
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Inhibitory Specificity Change of the Ovomucoid Third Domain of the Silver Pheasant upon Introduction of an Engineered Cys14−Cys39 Bond
Hemmi, Hikaru, Kumazaki, Takashi, Yamazaki, Toshimasa, Kojima, Shuichi, Yoshida, Takuya, Kyogoku, Yoshimasa, Katsu, Masataka, Shinohara, Fumikazu, Yokosawa, Hideyoshi, Miura, Kin-ichiro, Kobayashi, Yuji
Published in Biochemistry (Easton) (11.03.2003)
Published in Biochemistry (Easton) (11.03.2003)
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올리고뉴클레오티드 유도체 또는 그 염
HARUMOTO TOSHIMASA, HOMMA MASAKAZU, SHINOHARA FUMIKAZU, YAMAMOTO JUNICHIRO, HAGIWARA KENJI
Year of Publication 08.01.2020
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Year of Publication 08.01.2020
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폴리뉴클레오티드 및 의약 조성물
HOMMA MASAKAZU, HARADA KENJI, SHINOHARA FUMIKAZU, IWAI HIROTO, YAMAMOTO JUNICHIRO, KIMURA YASUAKI, ASANO KANA, MOTOSAWA KEIICHI, ABE HIROSHI, NAKAMOTO KOSUKE
Year of Publication 02.09.2022
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Year of Publication 02.09.2022
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OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF
HONMA, Masakazu, SHINOHARA, Fumikazu, HARUMOTO, Toshimasa, YAMAMOTO, Junichiro, HAGIWARA, Kenji
Year of Publication 01.11.2018
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Year of Publication 01.11.2018
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POLYNUCLEOTIDE AND MEDICINAL COMPOSITION
ASANO, Kana, MOTOSAWA, Keiichi, SHINOHARA, Fumikazu, KIMURA, Yasuaki, IWAI, Hiroto, NAKAMOTO, Kosuke, ABE, Hiroshi, YAMAMOTO, Junichiro, HOMMA, Masakazu, HARADA, Kenji
Year of Publication 01.07.2021
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Year of Publication 01.07.2021
Patent
OLIGONUCLEOTIDE DERIVATIVE
SHINOHARA, Fumikazu, ATSUMI, Toshiyuki, YAMAMOTO, Junichiro, SAWADA, Takashi, HAGIWARA, Kenji
Year of Publication 29.12.2016
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Year of Publication 29.12.2016
Patent
Specific association of increased vascular endothelial growth factor expression and its receptors with macrophage differentiation of HL-60 leukemia cells
Ohsaka, Akimichi, Hirota-Komatsu, Satoko, Shibata, Miki, Ezaki, Junji, Shinohara, Fumikazu, Yoshida, Tetsuo
Published in Biochemical and biophysical research communications (11.04.2008)
Published in Biochemical and biophysical research communications (11.04.2008)
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OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF
TAKAHASHI, YUICHI, SAITO, JUN-ICHI, KOUDA, YASUO, OASHI, TAIJI, NAKAJIMA, TAKAHIRO, NISHIKAWA, TOMOYUKI, SUZUKI, MICHIHIKO, YAMAMOTO, JUNICHIRO, SHINOHARA, FUMIKAZU, MAKINO, ASANA, NAKOJI, MASAYOSHI
Year of Publication 11.09.2015
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Year of Publication 11.09.2015
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COMPOSITION FOR INHIBITING TARGET GENE EXPRESSION
ISHII, TOSHIHIKO, ENOKIZONO, JUNICHI, SUGISHITA, HIROKO, YOSHIDA, TETSUO, SHINOHARA, FUMIKAZU, NAOI, TOMOYUKI
Year of Publication 26.07.2012
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Year of Publication 26.07.2012
Patent
Oligonucleotide derivative or salt thereof
Honma, Masakazu, Yamamoto, Junichiro, Shinohara, Fumikazu, Hagiwara, Kenji, Harumoto, Toshimasa
Year of Publication 15.02.2024
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Year of Publication 15.02.2024
Patent
COMPOSITION INHIBITING THE EXPRESSION OF TARGET GENE
YAGI, NOBUHIRO, SUGISHITA, HIROKO, SOGA, SHIRO, YOSHIDA, TETSUO, SHINOHARA, FUMIKAZU
Year of Publication 09.04.2009
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Year of Publication 09.04.2009
Patent
OLIGONUCLEOTIDE
TAKAHASHI, YUICHI, SAITO, JUN-ICHI, OASHI, TAIJI, NAKAJIMA, TAKAHIRO, NISHIKAWA, TOMOYUKI, SUZUKI, MICHIHIKO, YAMAMOTO, JUNICHIRO, SHINOHARA, FUMIKAZU, MAKINO, ASANA, NAKOJI, MASAYOSHI
Year of Publication 06.03.2014
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Year of Publication 06.03.2014
Patent