Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition
MIMURA, Naoya, HIDESHIMA, Teru, CIRSTEA, Diana, GORGUN, Gullu, MINAMI, Jiro, TAI, Yu-Tzu, RICHARDSON, Paul G, UTSUGI, Teruhiro, IWAMA, Atsushi, ANDERSON, Kenneth C, SHIMOMURA, Toshiyasu, SUZUKI, Rikio, OHGUCHI, Hiroto, RIZQ, Ola, KIKUCHI, Shohei, YOSHIDA, Yasuhiro, COTTINI, Francesca, JAKUBIKOVA, Jana
Published in Cancer research (Chicago, Ill.) (15.08.2014)
Published in Cancer research (Chicago, Ill.) (15.08.2014)
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MK-5108, a Highly Selective Aurora-A Kinase Inhibitor, Shows Antitumor Activity Alone and in Combination with Docetaxel
Shimomura, Toshiyasu, Hasako, Shinichi, Nakatsuru, Yoko, Mita, Takashi, Ichikawa, Koji, Kodera, Tsutomu, Sakai, Takumi, Nambu, Tadahiro, Miyamoto, Mayu, Takahashi, Ikuko, Miki, Satomi, Kawanishi, Nobuhiko, Ohkubo, Mitsuru, Kotani, Hidehito, Iwasawa, Yoshikazu
Published in Molecular cancer therapeutics (01.01.2010)
Published in Molecular cancer therapeutics (01.01.2010)
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Biological characterization of 2-aminothiazole-derived Cdk4/6 selective inhibitor in vitro and in vivo
Hirai, Hiroshi, Shimomura, Toshiyasu, Kobayashi, Makiko, Eguchi, Tomohiro, Taniguchi, Eri, Fukasawa, Kazuhiro, Machida, Takumitsu, Oki, Hiroko, Arai, Tsuyoshi, Ichikawa, Koji, Hasako, Shinichi, Haze, Kyosuke, Kodera, Tsutomu, Kawanishi, Nobuhiko, Takahashi-Suziki, Ikuko, Nakatsuru, Yoko, Kotani, Hidehito, Iwasawa, Yoshikazu
Published in Cell cycle (Georgetown, Tex.) (15.04.2010)
Published in Cell cycle (Georgetown, Tex.) (15.04.2010)
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Expression levels of p18INK4C modify the cellular efficacy of cyclin-dependent kinase inhibitors via regulation of Mcl-1 expression in tumor cell lines
Eguchi, Tomohiro, Itadani, Hiraku, Shimomura, Toshiyasu, Kawanishi, Nobuhiko, Hirai, Hiroshi, Kotani, Hidehito
Published in Molecular cancer therapeutics (01.06.2009)
Published in Molecular cancer therapeutics (01.06.2009)
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Novel anti-cancer compounds targeting the cell cycle
Hirai, Hiroshi, Shimomura, Toshiyasu, Komatani, Hideya, Kotani, Hidehito
Published in Nihon yakurigaku zasshi (01.01.2009)
Published in Nihon yakurigaku zasshi (01.01.2009)
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The RAIG Family Member, GPRC5D, Is Associated with Hard-Keratinized Structures
Inoue, Shinichi, Nambu, Tadahiro, Shimomura, Toshiyasu
Published in Journal of investigative dermatology (01.03.2004)
Published in Journal of investigative dermatology (01.03.2004)
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Abstract C177: TAS-117, a highly selective non-ATP competitive inhibitor of AKT demonstrated antitumor activity in combination with chemotherapeutic agents and molecular targeted drugs
Ichikawa, Koji, Abe, Tetsuya, Nagase, Hideki, Saito, Hitoshi, Fujita, Ryouto, Okada, Megumu, Yonekura, Kazuhiko, Shimomura, Toshiyasu, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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Abstract C178: TAS-117, a highly potent and selective non-ATP competitive inhibitor of AKT, demonstrates a toxicity profile with manageable hyperglycemia in rats
Moriyama, Kenji, Yamaguchi, Masahiro, Sugimoto, Shigeo, Matsumura, Hirofumi, Ninomiya, Fumiko, Besshi, Kazuhiko, Morita, Fumio, Hayashi, Taiji, Fujita, Ryouto, Fukushima, Hiroto, Shimomura, Toshiyasu, Yonekura, Kazuhiko, Utsugi, Teruhiro
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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TAS-117, a Novel Selective Akt Inhibitor Demonstrates Significant Growth Inhibition in Multiple Myeloma Cells in Vitro and in Vivo
Mimura, Naoya, Ohguchi, Hiroto, Cirstea, Diana, Cottini, Francesca, Gorgun, Gullu Topal, Minami, Jiro, Suzuki, Rikio, Shimomura, Toshiyasu, Utsugi, Teruhiro, Hideshima, Teru, Anderson, Kenneth C.
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Potent anti-tumor activity of a macrocycle-quinoxalinone class pan-Cdk inhibitor in vitro and in vivo
Hirai, Hiroshi, Takahashi-Suziki, Ikuko, Shimomura, Toshiyasu, Fukasawa, Kazuhiro, Machida, Takumitsu, Takaki, Toru, Kobayashi, Makiko, Eguchi, Tomohiro, Oki, Hiroko, Arai, Tsuyoshi, Ichikawa, Koji, Hasako, Shinichi, Kodera, Tsutomu, Kawanishi, Nobuhiko, Nakatsuru, Yoko, Kotani, Hidehito, Iwasawa, Yoshikazu
Published in Investigational new drugs (01.08.2011)
Published in Investigational new drugs (01.08.2011)
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NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF
KAMIJO KAORI, OHKUBO MITSURU, NIIYAMA KENJI, NAKAMURA MASAYUKI, SHIMOMURA TOSHIYASU
Year of Publication 01.04.2014
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Year of Publication 01.04.2014
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