Single‐ and multiple‐dose escalation study to assess pharmacokinetics, pharmacodynamics and safety of oral esaxerenone in healthy Japanese subjects
Kato, Manabu, Furuie, Hidetoshi, Shimizu, Takako, Miyazaki, Atsuhiro, Kobayashi, Fumiaki, Ishizuka, Hitoshi
Published in British journal of clinical pharmacology (01.08.2018)
Published in British journal of clinical pharmacology (01.08.2018)
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Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment
Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi
Published in European journal of clinical pharmacology (01.01.2022)
Published in European journal of clinical pharmacology (01.01.2022)
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Correction to: Physiologically based pharmacokinetic modelling to predict the clinical effect of CYP3A inhibitors/inducers on esaxerenone pharmacokinetics in healthy subjects and subjects with hepatic impairment
Watanabe, Akiko, Ishizuka, Tomoko, Yamada, Makiko, Igawa, Yoshiyuki, Shimizu, Takako, Ishizuka, Hitoshi
Published in European journal of clinical pharmacology (2022)
Published in European journal of clinical pharmacology (2022)
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Effects of itraconazole and rifampicin on the single‐dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects
Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Published in British journal of clinical pharmacology (01.10.2020)
Published in British journal of clinical pharmacology (01.10.2020)
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Acute effects of walking in forest environments on cardiovascular and metabolic parameters
Li, Qing, Otsuka, Toshiaki, Kobayashi, Maiko, Wakayama, Yoko, Inagaki, Hirofumi, Katsumata, Masao, Hirata, Yukiyo, Li, YingJi, Hirata, Kimiko, Shimizu, Takako, Suzuki, Hiroko, Kawada, Tomoyuki, Kagawa, Takahide
Published in European journal of applied physiology (01.11.2011)
Published in European journal of applied physiology (01.11.2011)
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Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects
Tachibana, Masaya, Matsuki, Shunji, Maekawa, Yutaro, Kuroda, Kana, Shimizu, Takako, Tsutsumi, Junko, Ishizuka, Hitoshi
Published in Clinical and translational science (01.11.2023)
Published in Clinical and translational science (01.11.2023)
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Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats
KAMEGAI, Jun, TAMURA, Hideki, SHIMIZU, Takako, ISHII, Shinya, SUGIHARA, Hitoshi, WAKABAYASHI, Ichiji
Published in Diabetes (New York, N.Y.) (01.11.2001)
Published in Diabetes (New York, N.Y.) (01.11.2001)
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Absolute Bioavailability of Esaxerenone and Food Effects on its Pharmacokinetics After a Single Oral Dose in Healthy Japanese Subjects: An Open-Label Crossover Study
Kurata, Akifumi, Furuie, Hidetoshi, Ishizuka, Tomoko, Nakatsu, Takafumi, Shimizu, Takako, Kato, Manabu, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Published in Advances in therapy (01.07.2019)
Published in Advances in therapy (01.07.2019)
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Visualization of the Distribution of Oxidizing Substances in an Atmospheric Pressure Plasma Jet
Kawasaki, Toshiyuki, Kawano, Kota, Mizoguchi, Hiroshi, Yano, Yuto, Yamashita, Keisuke, Sakai, Miho, Shimizu, Takako, Uchida, Giichiro, Koga, Kazunori, Shiratani, Masaharu
Published in IEEE transactions on plasma science (01.10.2014)
Published in IEEE transactions on plasma science (01.10.2014)
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Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects
Kirigaya, Yoshiaki, Shiramoto, Masanari, Ishizuka, Tomoko, Uchimaru, Hinako, Irie, Shin, Kato, Manabu, Shimizu, Takako, Nakatsu, Takafumi, Nishikawa, Yasuhiro, Ishizuka, Hitoshi
Published in BMC pharmacology & toxicology (29.07.2020)
Published in BMC pharmacology & toxicology (29.07.2020)
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Nrf2 Regulates the Risk of a Diesel Exhaust Inhalation-Induced Immune Response during Bleomycin Lung Injury and Fibrosis in Mice
Li, Ying-Ji, Shimizu, Takako, Shinkai, Yusuke, Hirata, Yukiyo, Inagaki, Hirofumi, Takeda, Ken, Azuma, Arata, Yamamoto, Masayuki, Kawada, Tomoyuki
Published in International journal of molecular sciences (17.03.2017)
Published in International journal of molecular sciences (17.03.2017)
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Clinical Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Novel Factor Xa Inhibitor DY-807f in Healthy Volunteers
Ogata, Koichiro, Shimizu, Takako, Masumoto, Hiroshi, Oguma, Toshihiro, Sugiyama, Nobutoshi, Kunitada, Satoshi
Published in Thrombosis research (01.04.2015)
Published in Thrombosis research (01.04.2015)
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Nrf2 Lowers the Risk of Lung Injury via Modulating the Airway Innate Immune Response Induced by Diesel Exhaust in Mice
Li, Ying-Ji, Shimizu, Takako, Shinkai, Yusuke, Ihara, Tomomi, Sugamata, Masao, Kato, Katsuhito, Kobayashi, Maiko, Hirata, Yukiyo, Inagaki, Hirofumi, Uzuki, Makoto, Akimoto, Toshio, Umezawa, Masakazu, Takeda, Ken, Azuma, Arata, Yamamoto, Masayuki, Kawada, Tomoyuki
Published in Biomedicines (21.10.2020)
Published in Biomedicines (21.10.2020)
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Structure Effect on Antioxidant Activity of Catecholamines toward Singlet Oxygen and Other Reactive Oxygen Species in vitro
Shimizu, Takako, Nakanishi, Yuji, Nakahara, Meiko, Wada, Naoki, Moro-oka, Yoshihiko, Hirano, Toru, Konishi, Tetsuya, Matsugo, Seiichi
Published in Journal of Clinical Biochemistry and Nutrition (01.11.2010)
Published in Journal of Clinical Biochemistry and Nutrition (01.11.2010)
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Effects of insulin, leptin, and glucagon on ghrelin secretion from isolated perfused rat stomach
Kamegai, Jun, Tamura, Hideki, Shimizu, Takako, Ishii, Shinya, Sugihara, Hitoshi, Oikawa, Shinichi
Published in Regulatory peptides (15.06.2004)
Published in Regulatory peptides (15.06.2004)
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EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: Importance in IL-8 transcription
Li, Ying-Ji, Shimizu, Takako, Hirata, Yukiyo, Inagaki, Hirofumi, Takizawa, Hajime, Azuma, Arata, Kawada, Tomoyuki, Sugawara, Isamu, Kudoh, Shoji, Sunazuka, Toshiaki, Omura, Satoshi
Published in Pulmonary pharmacology & therapeutics (01.06.2013)
Published in Pulmonary pharmacology & therapeutics (01.06.2013)
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Role of Ghrelin in Streptozotocin-Induced Diabetic Hyperphagia
Ishii, Shinya, Kamegai, Jun, Tamura, Hideki, Shimizu, Takako, Sugihara, Hitoshi, Oikawa, Shinichi
Published in Endocrinology (Philadelphia) (01.12.2002)
Published in Endocrinology (Philadelphia) (01.12.2002)
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Pharmacokinetics of R- and S-Carvedilol in Routinely Treated Japanese Patients with Heart Failure
Horiuchi, Isao, Nozawa, Takashi, Fujii, Nozomu, Inoue, Hiroshi, Honda, Mutsuko, Shimizu, Takako, Taguchi, Masato, Hashimoto, Yukiya
Published in Biological & pharmaceutical bulletin (01.05.2008)
Published in Biological & pharmaceutical bulletin (01.05.2008)
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