Genetic Variations in the Gene Encoding ELMO1 Are Associated With Susceptibility to Diabetic Nephropathy
Shimazaki, Atsuyuki, Kawamura, Yoshihiro, Kanazawa, Akio, Sekine, Akihiro, Saito, Susumu, Tsunoda, Tatsuhiko, Koya, Daisuke, Babazono, Tetsuya, Tanaka, Yasushi, Matsuda, Masafumi, Kawai, Koichi, Iiizumi, Tomohiro, Imanishi, Masahito, Shinosaki, Toshihiro, Yanagimoto, Toru, Ikeda, Minoru, Omachi, Shigeki, Kashiwagi, Atsunori, Kaku, Kohei, Iwamoto, Yasuhiko, Kawamori, Ryuzou, Kikkawa, Ryuichi, Nakajima, Masatoshi, Nakamura, Yusuke, Maeda, Shiro
Published in Diabetes (New York, N.Y.) (01.04.2005)
Published in Diabetes (New York, N.Y.) (01.04.2005)
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Journal Article
Acetyl-CoA carboxylase 2 inhibition reduces skeletal muscle bioactive lipid content and attenuates progression of type 2 diabetes in Zucker diabetic fatty rats
Takagi, Hiroyuki, Ikehara, Tatsuya, Hashimoto, Kumi, Tanimoto, Keiichi, Shimazaki, Atsuyuki, Kashiwagi, Yuto, Sakamoto, Shingo, Yukioka, Hideo
Published in European journal of pharmacology (05.11.2021)
Published in European journal of pharmacology (05.11.2021)
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Journal Article
A Novel Acetyl-CoA Carboxylase 2 Selective Inhibitor Improves Whole-Body Insulin Resistance and Hyperglycemia in Diabetic Mice through Target-Dependent Pathways
Takagi, Hiroyuki, Tanimoto, Keiichi, Shimazaki, Atsuyuki, Tonomura, Yutaka, Momosaki, Sotaro, Sakamoto, Shingo, Abe, Kohji, Notoya, Mitsuru, Yukioka, Hideo
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
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Journal Article
TLC-3595, a selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, improves steatosis and fibrosis in murine models of NASH via pleiotropic mechanisms
Vijayakumar, Archana, Murakami, Eisuke, Huss, Ryan, Sroda, Natalie, Shimazaki, Atsuyuki, Morita, Ippei, Kato, Hideaki, Nakai, Manami, Ohyabu, Naoki, Subramanian, Mani, Myers, Robert
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
WED-216 - TLC-3595, a selective acetyl-CoA carboxylase 2 (ACC2) inhibitor, improves steatosis and fibrosis in murine models of NASH via pleiotropic mechanisms
Vijayakumar, Archana, Murakami, Eisuke, Huss, Ryan, Sroda, Natalie, Shimazaki, Atsuyuki, Morita, Ippei, Kato, Hideaki, Nakai, Manami, Ohyabu, Naoki, Subramanian, Mani, Myers, Robert
Published in Journal of hepatology (01.06.2023)
Published in Journal of hepatology (01.06.2023)
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Journal Article
ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice
Takagi, Hiroyuki, Ikehara, Tatsuya, Kashiwagi, Yuto, Hashimoto, Kumi, Nanchi, Isamu, Shimazaki, Atsuyuki, Nambu, Hirohide, Yukioka, Hideo
Published in Endocrinology (Philadelphia) (01.08.2018)
Published in Endocrinology (Philadelphia) (01.08.2018)
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Journal Article
1775-P: Impact of Acetyl-CoA Carboxylase 2 Inhibition on Skeletal Muscle Diacylglycerol and Ceramide Levels and Its Potential Contribution to Improved Glucose Metabolism
TAKAGI, HIROYUKI, IKEHARA, TATSUYA, HASHIMOTO, KUMI, SHIMAZAKI, ATSUYUKI, KASHIWAGI, YUTO, NISHIURA, YUJI, NOTOYA, MITSURU, YUKIOKA, HIDEO
Published in Diabetes (New York, N.Y.) (01.06.2019)
Published in Diabetes (New York, N.Y.) (01.06.2019)
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Journal Article
849-P: Antidiabetic Effects of TLC-3595, a Selective ACC2 Inhibitor, in ZDF Rats
VIJAYAKUMAR, ARCHANA, MURAKAMI, EISUKE, HUSS, RYAN S., SRODA, NATALIE, SHIMAZAKI, ATSUYUKI, KASHIWAGI, YUTO, MYERS, ROBERT P., SUBRAMANIAN, MANI, SHULMAN, GERALD I.
Published in Diabetes (New York, N.Y.) (20.06.2023)
Published in Diabetes (New York, N.Y.) (20.06.2023)
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Journal Article
MEDICINE THAT TARGETS ACC2
SHIMAZAKI ATSUYUKI, MITSUOKA YASUNORI, UNO (USUI) MAI, MORINAGA TAKUMI
Year of Publication 15.05.2023
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Year of Publication 15.05.2023
Patent
Discovery of a novel olefin derivative as a highly potent and selective acetyl-CoA carboxylase 2 inhibitor with in vivo efficacy
Nishiura, Yuji, Matsumura, Akira, Kobayashi, Naotake, Shimazaki, Atsuyuki, Sakamoto, Shingo, Kitade, Naohisa, Tonomura, Yutaka, Ino, Akira, Okuno, Takayuki
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
Published in Bioorganic & medicinal chemistry letters (01.08.2018)
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Journal Article
Processing Pathway Deduced from the Structures of N-Glycans in Carica papaya
Makino, Yasushi, Shimazaki, Atsuyuki, Omichi, Kaoru, Odani, Shoji, Hase, Sumihiro
Published in Journal of biochemistry (Tokyo) (01.06.2000)
Published in Journal of biochemistry (Tokyo) (01.06.2000)
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Journal Article
new sugar chain of the proteinase inhibitor from latex of Carica papaya
Shimazaki, A, Makino, Y, Omichi, K, Odani, S, Hase, S
Published in Journal of biochemistry (Tokyo) (01.03.1999)
Published in Journal of biochemistry (Tokyo) (01.03.1999)
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Journal Article
PHARMACEUTICAL FOR TREATING HEART DISEASE OR SKELETAL MUSCLE DISEASE
SHIMAZAKI Atsuyuki, YUKIOKA Hideo, YAMADA Tomomi, YOSHIDA Yasunobu, UNO USUI Mai, KASHIWAGI Yuto
Year of Publication 25.05.2023
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Year of Publication 25.05.2023
Patent
Genetic variations in the gene encoding ELM01 are associated with susceptibility to diabetic nephropathy
SHIMAZAKI, Atsuyuki, KAWAMURA, Yoshihiro, KAWAI, Koichi, IIIZUMI, Tomohiro, IMANISHI, Masahito, SHINOSAKI, Toshihiro, YANAGIMOTO, Toru, IKEDA, Minoru, OMACHI, Shigeki, KASHIWAGI, Atsunori, KAKU, Kohei, IWAMOTO, Yasuhiko, KANAZAWA, Akio, KAWAMORI, Ryuzou, KIKKAWA, Ryuichi, NAKAJIMA, Masatoshi, NAKAMURA, Yusuke, MAEDA, Shiro, SEKINE, Akihiro, SAITO, Susumu, TSUNODA, Tatsuhiko, KOYA, Daisuke, BABAZONO, Tetsuya, TANAKA, Yasushi, MATSUDA, Masafumi
Published in Diabetes (New York, N.Y.) (01.04.2005)
Published in Diabetes (New York, N.Y.) (01.04.2005)
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Journal Article
Association of ELMO1 and Diabetic Nephropathy in Japanese Subjects with Type2 Diabetes
Maeda, Shiro, Shimazaki, Atsuyuki, Kawamura, Yoshihiro, Koya, Daisuke
Published in Diabetes (New York, N.Y.) (01.06.2005)
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Published in Diabetes (New York, N.Y.) (01.06.2005)
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