Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia
Mori, Masamichi, Kaneko, Naoki, Ueno, Yoko, Yamada, Masaki, Tanaka, Ruriko, Saito, Rika, Shimada, Itsuro, Mori, Kenichi, Kuromitsu, Sadao
Published in Investigational new drugs (01.10.2017)
Published in Investigational new drugs (01.10.2017)
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Discovery of N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor
Iikubo, Kazuhiko, Kondoh, Yutaka, Shimada, Itsuro, Matsuya, Takahiro, Mori, Kenichi, Ueno, Yoko, Okada, Minoru
Published in Chemical & pharmaceutical bulletin (2018)
Published in Chemical & pharmaceutical bulletin (2018)
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The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice
Mori, Masamichi, Ueno, Yoko, Konagai, Satoshi, Fushiki, Hiroshi, Shimada, Itsuro, Kondoh, Yutaka, Saito, Rika, Mori, Kenichi, Shindou, Nobuaki, Soga, Takatoshi, Sakagami, Hideki, Furutani, Takashi, Doihara, Hitoshi, Kudoh, Masafumi, Kuromitsu, Sadao
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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Atropisomeric 4‑Phenyl‑4H‑1,2,4-triazoles as Selective Glycine Transporter 1 Inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Journal Article
Characterization and Thermodynamic Stability of Polymorphs of Di(arylamino) Aryl Compound ASP3026
Takeguchi, Kazuhiro, Hirakura, Yutaka, Yamazaki, Kouji, Shimada, Itsuro, Ieda, Shigeru, Okada, Minoru, Takiyama, Hiroshi
Published in Chemical & pharmaceutical bulletin (01.06.2015)
Published in Chemical & pharmaceutical bulletin (01.06.2015)
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Abstract 866: ASP3026, a selective ALK inhibitor, induces tumor regression in a crizotinib-refractory model and prolongs survival in an intrapleurally xenograft model
Mori, Masamichi, Kuromitsu, Sadao, Ueno, Yoko, Tanaka, Ruriko, Shimada, Itsuro, Kondoh, Yutaka, Konagai, Satoshi, Sakagami, Hideki, Fushiki, Hiroshi, Saito, Rika, Sengoku, Takanori
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Abstract 2821: Anti-tumor activity of ASP3026, – A novel and selective ALK inhibitor
Kuromitsu, Sadao, Mori, Masamichi, Shimada, Itsuro, Kondoh, Yutaka, Shindoh, Nobuaki, Soga, Takatoshi, Furutani, Takashi, Konagai, Satoshi, Sakagami, Hideki, Nakata, Mari, Ueno, Yoko, Saito, Rika, Sasamata, Masao, Mano, Hiroyuki, Kudou, Masafumi
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist
Kimura, Yasuharu, Hatanaka, Ken-ichi, Naitou, Yuki, Maeno, Kyoichi, Shimada, Itsuro, Koakutsu, Akiko, Wanibuchi, Fumikazu, Yamaguchi, Tokio
Published in European journal of pharmacology (01.01.2004)
Published in European journal of pharmacology (01.01.2004)
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Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists
SHIMADA, Itsuro, MAENO, Kyoichi, TSUKAMOTO, Shin-Ichi, KONDOH, Yutaka, KAKU, Hidetaka, SUGASAWA, Keizo, KIMURA, Yasuharu, HATANAKA, Ken-Ichi, NAITOU, Yuki, WANIBUCHI, Fumikazu, SAKAMOTO, Shuichi
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl} prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors
Imaizumi, Tomoyoshi, Shimada, Itsuro, Satake, Yoshiki, Yamaki, Susumu, Koike, Takanori, Nigawara, Takahiro, Kaneko, Osamu, Amano, Yasushi, Mori, Kenichi, Yamanaka, Yosuke, Nakayama, Ayako, Nishizono, Yoshihiro, Shimazaki, Masashi, Nagashima, Takeyuki, Kuramoto, Kazuyuki
Published in Bioorganic & medicinal chemistry (15.01.2024)
Published in Bioorganic & medicinal chemistry (15.01.2024)
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Synthesis and structure–activity relationships of pyrazine-2-carboxamide derivatives as novel echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) inhibitors
Iikubo, Kazuhiko, Kurosawa, Kazuo, Matsuya, Takahiro, Kondoh, Yutaka, Kamikawa, Akio, Moritomo, Ayako, Iwai, Yoshinori, Tomiyama, Hiroshi, Shimada, Itsuro
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Journal Article
An efficient preparative route to 7-ethyl-1H-furo[2,3-g]indazole
Shimada, Maeno, K, Kimizuka, T, Goto, S, Takahashi, T, Nakamura, A, Miyafuji, A, Tsukamoto, S, Sakamoto, S
Published in Heterocycles (01.01.2004)
Published in Heterocycles (01.01.2004)
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Atropisomeric 4-Phenyl-4 H -1,2,4-triazoles as Selective Glycine Transporter 1 Inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (25.07.2013)
Published in Journal of medicinal chemistry (25.07.2013)
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Journal Article
ASP2215, a novel FLT3/AXL inhibitor: Preclinical evaluation in combination with cytarabine and anthracycline in acute myeloid leukemia (AML)
Ueno, Yoko, Kaneko, Naoki, Saito, Rika, Kondoh, Yutaka, Shimada, Itsuro, Mori, Masamichi, Kuromitsu, Sadao
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4 H -1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Kohara, Atsuyuki, Morita, Takuma, Doihara, Hitoshi, Saita, Kyouko, Aota, Masaki, Furutani, Masako, Shimada, Yoshiaki, Hamada, Noritaka, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
Synthesis and Biological Evaluation of 3-Biphenyl-4-yl-4-phenyl-4H-1,2,4-triazoles as Novel Glycine Transporter 1 Inhibitors
Sugane, Takashi, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Kohara, Atsuyuki, Morita, Takuma, Doihara, Hitoshi, Saita, Kyouko, Aota, Masaki, Furutani, Masako, Shimada, Yoshiaki, Hamada, Noritaka, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Journal Article
ASP2215, a novel FLT3/AXL inhibitor: Preclinical evaluation in acute myeloid leukemia (AML)
Mori, Masamichi, Kaneko, Naoki, Ueno, Yoko, Tanaka, Ruriko, Cho, Kathy, Saito, Rika, Kondoh, Yutaka, Shimada, Itsuro, Kuromitsu, Sadao
Published in Journal of clinical oncology (20.05.2014)
Published in Journal of clinical oncology (20.05.2014)
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Journal Article
Regioselective Robinson Annulation Realized by the Combined Use of Lithium Enolates and Aluminum Tris(2,6-diphenylphenoxide) (ATPH)
Saito, Susumu, Shimada, Itsuro, Takamori, Yusuke, Tanaka, Michiaki, Maruoka, Keiji, Yamamoto, Hisashi
Published in Bulletin of the Chemical Society of Japan (01.07.1997)
Published in Bulletin of the Chemical Society of Japan (01.07.1997)
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Abstract 918: ASP3026, a selective ALK inhibitor, shows anti-tumor activity in a mouse model xenografted with NCI-H2228 intracranially
Konagai, Satoshi, Fushiki, Hiroshi, Sakagami, Hideki, Ueno, Yoko, Mori, Masamichi, Shimada, Itsuro, Kondoh, Yutaka, Miyoshi, Sousuke, Nishimura, Shintaro, Kuromitsu, Sadao
Published in Cancer research (Chicago, Ill.) (15.04.2013)
Published in Cancer research (Chicago, Ill.) (15.04.2013)
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Practical and efficient synthesis of the (R)-atropisomer of a 4-phenyl 1,2,4-triazole derivative as a selective GlyT1 inhibitor
Sugane, Takashi, Hamada, Noritaka, Tobe, Takahiko, Hamaguchi, Wataru, Shimada, Itsuro, Maeno, Kyoichi, Miyata, Junji, Suzuki, Takeshi, Kimizuka, Tetsuya, Sakamoto, Shuichi, Tsukamoto, Shin-ichi
Published in Tetrahedron: asymmetry (15.12.2012)
Published in Tetrahedron: asymmetry (15.12.2012)
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