Results from a new efficacy and safety analysis of the REGENERATE trial of obeticholic acid for treatment of pre-cirrhotic fibrosis due to non-alcoholic steatohepatitis
Sanyal, Arun J., Ratziu, Vlad, Loomba, Rohit, Anstee, Quentin M., Kowdley, Kris V., Rinella, Mary E., Sheikh, Muhammad Y., Trotter, James F., Knapple, Whitfield, Lawitz, Eric J., Abdelmalek, Manal F., Newsome, Philip N., Boursier, Jérôme, Mathurin, Philippe, Dufour, Jean-François, Berrey, M. Michelle, Shiff, Steven J., Sawhney, Sangeeta, Capozza, Thomas, Leyva, Rina, Harrison, Stephen A., Younossi, Zobair M.
Published in Journal of hepatology (01.11.2023)
Published in Journal of hepatology (01.11.2023)
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Two Randomized Trials of Linaclotide for Chronic Constipation
Lembo, Anthony J, Schneier, Harvey A, Shiff, Steven J, Kurtz, Caroline B, MacDougall, James E, Jia, Xinwei D, Shao, James Z, Lavins, Bernard J, Currie, Mark G, Fitch, Donald A, Jeglinski, Brenda I, Eng, Paul, Fox, Susan M, Johnston, Jeffrey M
Published in The New England journal of medicine (11.08.2011)
Published in The New England journal of medicine (11.08.2011)
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Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial
Lacy, Brian E, Schey, Ron, Shiff, Steven J, Lavins, Bernard J, Fox, Susan M, Jia, Xinwei D, Blakesley, Rick E, Hao, Xinming, Cronin, Jacquelyn A, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M, Lembo, Anthony J
Published in PloS one (29.07.2015)
Published in PloS one (29.07.2015)
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Linaclotide for Irritable Bowel Syndrome With Constipation: A 26-Week, Randomized, Double-blind, Placebo-Controlled Trial to Evaluate Efficacy and Safety
CHEY, William D, LEMBO, Anthony J, BAIRD, Mollie J, SCHNEIER, Harvey A, JOHNSTON, Jeffrey M, LAVINS, Bernard J, SHIFF, Steven J, KURTZ, Caroline B, CURRIE, Mark G, MACDOUGALL, James E, JIA, Xinwei D, SHAO, James Z, FITCH, Donald A
Published in The American journal of gastroenterology (01.11.2012)
Published in The American journal of gastroenterology (01.11.2012)
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Journal Article
A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation
RAO, Satish, LEMBO, Anthony J, FOX, Susan M, SCHNEIER, Harvey A, KURTZ, Caroline B, JOHNSTON, Jeffrey M, SHIFF, Steven J, LAVINS, Bernard J, CURRIE, Mark G, JIA, Xinwei D, SHI, Kelvin, MACDOUGALL, James E, SHAO, James Z, ENG, Paul
Published in The American journal of gastroenterology (01.11.2012)
Published in The American journal of gastroenterology (01.11.2012)
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Journal Article
Response to Miner et al
Currie, Mark G, Shiff, Steven J, Schneier, Harvey A, Johnston, Jeffrey M
Published in The American journal of gastroenterology (01.11.2017)
Published in The American journal of gastroenterology (01.11.2017)
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Journal Article
Effect of Linaclotide on Severe Abdominal Symptoms in Patients With Irritable Bowel Syndrome With Constipation
Rao, Satish S.C, Quigley, Eamonn M.M, Shiff, Steven J, Lavins, Bernard J, Kurtz, Caroline B, MacDougall, James E, Currie, Mark G, Johnston, Jeffrey M
Published in Clinical gastroenterology and hepatology (01.04.2014)
Published in Clinical gastroenterology and hepatology (01.04.2014)
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Tu1070 The Effect of Linaclotide on IBS-QOL Sexual Subscale Scores in Patients With Irritable Bowel Syndrome With Constipation: Results From a Post Hoc Analysis of 2 Phase 3 Trials of Linaclotide
Currie, Mark G, Shiff, Steven J, Hao, Xinming, Carson, Robyn, Baird, Mollie J, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
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Sa2008 Efficacy and Safety of Linaclotide in Chronic Idiopathic Constipation Patients With Abdominal Bloating: Phase 3b Trial Results
Lacy, Brian E, Lembo, Anthony, Schey, Ron, Lavins, Bernard J, Eng, Paul F, Fox, Susan M, Jia, Xinwei D, Hao, Xinming, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey, Shiff, Steven J
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
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Journal Article
Efficacy and Safety of Once Daily Linaclotide in Patients With Irritable Bowel Syndrome With Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial Followed by a 4-Week Randomized Withdrawal Period
Rao, Satish, Lembo, Anthony, Shiff, Steven J, Shi, Kelvin, Johnston, Jeffrey M, Schneier, Harvey
Published in Gastroenterology (New York, N.Y. 1943) (2011)
Published in Gastroenterology (New York, N.Y. 1943) (2011)
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Journal Article
Tu1380 Assessing the Percent of Days Linaclotide Improved Abdominal Symptoms and Stool Frequency in Patients With IBS-C: A Pooled Analysis of Two Phase 3 Trials
Rao, Satish S, Chang, Lin, Hao, Xinming, Lavins, Bernard J, Shiff, Steven J, Cao, Xiaofan, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Journal Article
Tu1401 Factors Contributing to Treatment Satisfaction in Patients With Irritable Bowel Syndrome With Constipation (IBS-C) Treated With Linaclotide vs Placebo
Lembo, Anthony, Carson, Robyn, Shiff, Steven J, Lavins, Bernard J, MacDougall, James E, Shi, Kelvin, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Journal Article
Mo2054 Assessing Abdominal and Bowel Symptoms Using Adequate Relief Based Thresholds: Results From 2 Phase 3 Trials of Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
Camilleri, Michael, Lembo, Anthony, Lavins, Bernard J, MacDougall, James E, Shiff, Steven J, Jia, Xinwei D, Currie, Mark G, Kurtz, Caroline B, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
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Journal Article
Su2033 Determining the Minimum Duration for Initial Treatment With Linaclotide in IBS-C Patients: Results From Pooled Phase 3 Trials
Chey, William D, Lavins, Bernard J, Shiff, Steven J, MacDougall, James E, Kurtz, Caroline B, Shi, Kelvin, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
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Journal Article
Tu1423 Effects of Linaclotide on Straining Associated With Bowel Movements in Patients With Irritable Bowel Syndrome With Constipation (IBS-C): A Post Hoc Analysis of Pooled Data From Two Phase 3 Trials
Lembo, Anthony, Rao, Satish S, Shiff, Steven J, Lavins, Bernard J, MacDougall, James E, Shi, Kelvin, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Journal Article
Sa1098 Mediation Analysis Supports a Direct Effect of Linaclotide on Relief of Abdominal Pain Independent of Constipation Improvement
MacDougall, James E, MacKinnon, David P, Lavins, Bernard J, Lembo, Anthony, Shiff, Steven J, Schneier, Harvey, Hao, Xinming, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Journal Article
Tu1069 Do Baseline Factors Contribute to Treatment Satisfaction in Patients With Chronic Constipation Treated With Linaclotide vs Placebo?
Schoenfeld, Philip S, Chang, Lin, Carson, Robyn, Shiff, Steven J, Lavins, Bernard J, MacDougall, James E, Jia, Xinwei D, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Journal Article
Mo1858 Characterization and Association of Abdominal Pain With Anxiety or Depression in Patients With Irritable Bowel Syndrome With Constipation
Quigley, Eamonn M, Lavins, Bernard J, Shiff, Steven J, Shi, Kelvin, Hao, Xinming, Kurtz, Caroline B, Currie, Mark G, Schneier, Harvey, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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Journal Article
848 Efficacy of Linaclotide in Improving Abdominal Symptoms Rated as Most Severe by Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
Rao, Satish S, Quigley, Eamonn M, Shiff, Steven J, Lavins, Bernard J, Kurtz, Caroline B, MacDougall, James E, Shi, Kelvin, Schneier, Harvey, Currie, Mark G, Johnston, Jeffrey M
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2012)
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