Evidence for calmodulin inter-domain compaction in solution induced by W-7 binding
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Published in FEBS letters (15.01.1999)
Published in FEBS letters (15.01.1999)
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Novel Potassium Channel Activators. III. Synthesis and Pharmacological Evaluation of 3, 4-Dihydro-2H-1, 4-benzoxazine Derivatives : Modification at the 2 Position
MATSUMOTO, Yuzo, UCHIDA, Wataru, NAKAHARA, Hideaki, YANAGISAWA, Isao, SHIBANUMA, Tadao, NOHIRA, Hiroyuki
Published in Chemical & pharmaceutical bulletin (2000)
Published in Chemical & pharmaceutical bulletin (2000)
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Novel potassium channel activators. II. Synthesis and pharmacological evaluation of 3,4-dihydro-2H-1,4-benzoxazine derivatives: Modification of the aromatic part
Matsumoto, Y, Tsuzuki, R, Matsuhisa, A, Masuda, N, Yamagiwa, Y, Yanagisawa, Shibanuma, T, Nohira, H
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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Selective Muscarinic Antagonists. II. Synthesis and Antimuscarinic Properties of Biphenylylcarbamate Derivatives
NAITO, Ryo, TAKEUCHI, Makoto, MORIHIRA, Koichiro, HAYAKAWA, Masahiko, IKEDA, Ken, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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Selective Muscarinic Antagonists. I. Synthesis and Antimuscarinic Properties of 4-Piperidyl Benzhydrylcarbamate Derivatives
NAITO, Ryo, TAKEUCHI, Makoto, MORIHIRA, Koichiro, HAYAKAWA, Masahiko, IKEDA, Ken, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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Synthesis and Biological Evaluation of 1, 2, 3, 4-Tetrahydroisoquinoline Derivatives as Potent and Selective M2 Muscarinic Receptor Antagonists
WATANABE, Toshihiro, KINOYAMA, Isao, TAKIZAWA, Kenji, HIRANO, Seiko, SHIBANUMA, Tadao
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. I. Design and Synthesis of (.+-.)-N-(2-(3,4-Dichlorophenyl)-4-(spiro(isobenzofuran-1(3H),4'-piperidin)-1'-yl)butyl)-N-methylbenzamide, YM-35375, as a New Lead Compound for Novel Neurokinin Receptor Antagonists
KUBOTA, Hirokazu, FUJII, Masahiro, IKEDA, Ken, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. II. Syntheses and NK2 Receptor-Antagonistic Activities of N-(2-Aryl-4-(spiro-substituted piperidin-1'-yl)butyl)carboxamides
KUBOTA, Hirokazu, KAKEFUDA, Akio, NAGAOKA, Hitoshi, YAMAMOTO, Osamu, IKEDA, Ken, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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Peptide Based Interleukin-1.BETA. Converting Enzyme(ICE) Inhibitors: Synthesis, Structure Activity Relationships and Crystallographic Study of the ICE-inhibitor Complex
OKAMOTO, Yoshinori, ANAN, Hideki, NAKAI, Eiichi, MORIHIRA, Koichiro, YONETOKU, Yasuhiro, KURIHARA, Hiroyuki, SAKASHITA, Hitoshi, TERAI, Yoshiya, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1999)
Published in Chemical & pharmaceutical bulletin (1999)
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Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. III. Synthesis of (.+-.)-N-12-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1-yl)butyll-N-methylbenzamides and Evaluation of NK1-NK2 Dual Antagonistic Activities
KUBOTA, Hirokazu, KAKEFUDA, Akio, OKAMOTO, Yoshinori, FUJII, Masahiro, YAMAMOTO, Osamu, YAMAGIWA, Yoko, ORITA, Masaya, IKEDA, Ken, TAKEUCHI, Makoto, SHIBANUMA, Tadao, ISOMURA, Yasuo
Published in Chemical & pharmaceutical bulletin (1998)
Published in Chemical & pharmaceutical bulletin (1998)
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STUDIES ON β-LACTAM ANTIBIOTICS: II. SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS WITH SUBSTITUTED 1, 3-DITHIETANE DIRECTLY ATTACHED TO THE C-3 POSITION
NAGANO, NORIAKI, NAKANO, KOHJI, SHIBANUMA, TADAO, HARA, RYUICHIRO
Published in Journal of antibiotics (1991)
Published in Journal of antibiotics (1991)
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Synthesis of New Water-soluble Dihydropyridine Vasodilators
IWANAMI, MASARU, SHIBANUMA, TADAO, FUJIMOTO, MASAHARU, KAWAI, RYUTARO, TAMAZAWA, KAZUHARU, TAKENAKA, TOICHI, TAKAHASHI, KOZO, MURAKAMI, MASUO
Published in Chemical & pharmaceutical bulletin (01.01.1979)
Published in Chemical & pharmaceutical bulletin (01.01.1979)
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Synthesis of Optically Active 2-(N-Benzyl-N-methylamino)ethyl Methyl 2, 6-Dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate (Nicardipine)
SHIBANUMA, TADAO, IWANANI, MASARU, OKUDA, KOUHEI, TAKENAKA, TOICHI, MURAKAMI, MASUO
Published in Chemical & pharmaceutical bulletin (01.01.1980)
Published in Chemical & pharmaceutical bulletin (01.01.1980)
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Novel potassium channel openers. Part 4: Transformation of the 1,4-benzoxazine skeleton into 1,4-benzothiazine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroquinoxaline, indoline, and 1,5-benzoxazepine
MATSUMOTO, Y, TSUZUKI, R, MATSUHISA, A, YODEN, T, YAMAGIWA, Y, YANAGISAWA, I, SHIBANUMA, T, NOHIRA, H
Published in Bioorganic & medicinal chemistry (01.02.2000)
Published in Bioorganic & medicinal chemistry (01.02.2000)
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Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2, 6-Dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)
SHIBANUMA, TADAO, IWANAMI, MASARU, FUJIMOTO, MASAHARU, TAKENAKA, TOICHI, MURAKAMI, MASUO
Published in Chemical & pharmaceutical bulletin (01.01.1980)
Published in Chemical & pharmaceutical bulletin (01.01.1980)
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Adsorption of endotoxins on glass in the presence of cationic proteins
YOKOTA, Hiroyuki, KIYONAGA, Hiroshi, KANIWA, Hidetoshi, SHIBANUMA, Tadao
Published in Journal of pharmaceutical and biomedical analysis (01.07.2001)
Published in Journal of pharmaceutical and biomedical analysis (01.07.2001)
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Synthesis of New Cephamycin Derivatives and a Novel Rearrangement between Isothiazolethioacetamides and 1, 3-Dithietanecarboxamides
IWANAMI, MASARU, MAEDA, TETSUYA, FUJIMOTO, MASAHARU, NAGANO, YOSHINOBU, NAGANO, NORIAKI, YAMAZAKI, ATSUKI, SHIBANUMA, TADAO, TAMAZAWA, KAZUHARU, YANO, KUNIICHIRO
Published in Chemical & pharmaceutical bulletin (01.01.1980)
Published in Chemical & pharmaceutical bulletin (01.01.1980)
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