Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes
Forrest, M, Sun, S-Y, Hajdu, R, Bergstrom, J, Card, D, Doherty, G, Hale, J, Keohane, C, Meyers, C, Milligan, J, Mills, S, Nomura, N, Rosen, H, Rosenbach, M, Shei, G-J, Singer, I I, Tian, M, West, S, White, V, Xie, J, Proia, R L, Mandala, S
Published in The Journal of pharmacology and experimental therapeutics (01.05.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2004)
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Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors
DOUGLAS, C. M, D'IPPOLITO, J. A, MITCHELL, A, KURTZ, M. B, SHEI, G. J, MEINZ, M, ONISHI, J, MARRINAN, J. A, LI, W, ABRUZZO, G. K, FLATTERY, A, BARTIZAL, K
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
Published in Antimicrobial Agents and Chemotherapy (01.11.1997)
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Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists
Mandala, Suzanne, Hajdu, Richard, Bergstrom, James, Quackenbush, Elizabeth, Xie, Jenny, Milligan, James, Thornton, Rosemary, Shei, Gan-Ju, Card, Deborah, Keohane, CarolAnn, Rosenbach, Mark, Hale, Jeffrey, Lynch, Christopher L., Rupprecht, Kathleen, Parsons, William, Rosen, Hugh
Published in Science (American Association for the Advancement of Science) (12.04.2002)
Published in Science (American Association for the Advancement of Science) (12.04.2002)
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Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8
Im, Dong-Soon, Heise, Christopher E., Ancellin, Nicolas, O'Dowd, Brian F., Shei, Gan-ju, Heavens, Robert P., Rigby, Michael R., Hla, Timothy, Mandala, Suzanne, McAllister, George, George, Susan R., Lynch, Kevin R.
Published in The Journal of biological chemistry (12.05.2000)
Published in The Journal of biological chemistry (12.05.2000)
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Mutations in the HML E silencer of Saccharomyces cerevisiae yield metastable inheritance of transcriptional repression
MAHONEY, D. J, MARQUARDT, R, SHEI, G.-J, ROSE, A. B, BROACH, J. R
Published in Genes & development (01.04.1991)
Published in Genes & development (01.04.1991)
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Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P(1)) receptor agonists with exceptional selectivity against S1P(2) and S1P(3)
Li, Z, Chen, WR, Hale, JJ, Lynch, CL, Mills, SG, Hajdu, R, Keohane, CA, Rosenbach, MJ, Milligan, JA, Shei, GJ, Chrebet, G, Parent, SA, Bergstrom, J, Card, D, Forrest, M, Quackenbush, EJ, Wickham, LA, Vargas, H, Evans, RM, Rosen, H, Mandala, S
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P sub(1)) Receptor Agonists with Exceptional Selectivity against S1P sub(2) and S1P sub(3)
Li, Z, Chen, W, Hale, J J, Lynch, CL, Mills, S G, Hajdu, R, Keohane, CA, Rosenbach, MJ, Milligan, JA, Shei, G-J, Chrebet, G, Parent, SA, Bergstrom, J, Card, D
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists
Hale, Jeffrey J, Lynch, Christopher L, Neway, William, Mills, Sander G, Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J, Milligan, James A, Shei, Gan-Ju, Parent, Stephen A, Chrebet, Gary, Bergstrom, James, Card, Deborah, Ferrer, Marc, Hodder, Peter, Strulovici, Berta, Rosen, Hugh, Mandala, Suzanne
Published in Journal of medicinal chemistry (30.12.2004)
Published in Journal of medicinal chemistry (30.12.2004)
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Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720
Hale, Jeffrey J., Neway, William, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Koo, Gloria C., Koprak, Sam L., Jackson, Jesse J., Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
Published in Bioorganic & medicinal chemistry letters (21.06.2004)
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Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
Hale, Jeffrey J., Yan, Lin, Neway, William E., Hajdu, Richard, Bergstrom, James D., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary L., Thornton, Rosemary A., Card, Deborah, Rosenbach, Mark, HughRosen, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry (15.09.2004)
Published in Bioorganic & medicinal chemistry (15.09.2004)
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2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors
Yan, Lin, Budhu, Richard, Huo, Pei, Lynch, Christopher L., Hale, Jeffrey J., Mills, Sander G., Hajdu, Richard, Keohane, Carol A., Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Mandala, Suzanne M.
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
Published in Bioorganic & medicinal chemistry letters (01.07.2006)
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2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists
Colandrea, Vincent J., Legiec, Irene E., Huo, Pei, Yan, Lin, Hale, Jeffrey J., Mills, Sander G., Bergstrom, James, Card, Deborah, Chebret, Gary, Hajdu, Richard, Keohane, Carol Ann, Milligan, James A., Rosenbach, Mark J., Shei, Gan-Ju, Mandala, Suzanne M.
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Design and synthesis of conformationally constrained 3-( N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
Yan, Lin, Hale, Jeffrey J., Lynch, Christopher L., Budhu, Richard, Gentry, Amy, Mills, Sander G., Hajdu, Richard, Keohane, Carol Ann, Rosenbach, Mark J., Milligan, James A., Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne M.
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
Published in Bioorganic & medicinal chemistry letters (04.10.2004)
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The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists
Hale, Jeffrey J., Doherty, George, Toth, Leslie, Li, Zhen, Mills, Sander G., Hajdu, Richard, Ann Keohane, Carol, Rosenbach, Mark, Milligan, James, Shei, Gan-Ju, Chrebet, Gary, Bergstrom, James, Card, Deborah, Rosen, Hugh, Mandala, Suzanne
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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