Predicting the structural basis of targeted protein degradation by integrating molecular dynamics simulations with structural mass spectrometry
Dixon, Tom, MacPherson, Derek, Mostofian, Barmak, Dauzhenka, Taras, Lotz, Samuel, McGee, Dwight, Shechter, Sharon, Shrestha, Utsab R., Wiewiora, Rafal, McDargh, Zachary A., Pei, Fen, Pal, Rajat, Ribeiro, João V., Wilkerson, Tanner, Sachdeva, Vipin, Gao, Ning, Jain, Shourya, Sparks, Samuel, Li, Yunxing, Vinitsky, Alexander, Zhang, Xin, Razavi, Asghar M., Kolossváry, István, Imbriglio, Jason, Evdokimov, Artem, Bergeron, Louise, Zhou, Wenchang, Adhikari, Jagat, Ruprecht, Benjamin, Dickson, Alex, Xu, Huafeng, Sherman, Woody, Izaguirre, Jesus A.
Published in Nature communications (06.10.2022)
Published in Nature communications (06.10.2022)
Get full text
Journal Article
Riok1, A Novel Potential Target in MSI-High p53 Mutant Colorectal Cancer Cells
Shechter, Sharon, Ya'ar Bar, Sapir, Khattib, Hamdan, Gage, Matthew J, Avni, Dorit
Published in Molecules (Basel, Switzerland) (31.05.2023)
Published in Molecules (Basel, Switzerland) (31.05.2023)
Get full text
Journal Article
Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors
Kalid, Ori, Toledo Warshaviak, Dora, Shechter, Sharon, Sherman, Woody, Shacham, Sharon
Published in Journal of computer-aided molecular design (01.11.2012)
Published in Journal of computer-aided molecular design (01.11.2012)
Get full text
Journal Article
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription
Gerald, Damien, Adini, Irit, Shechter, Sharon, Perruzzi, Carole, Varnau, Joseph, Hopkins, Benjamin, Kazerounian, Shiva, Kurschat, Peter, Blachon, Stephanie, Khedkar, Santosh, Bagchi, Mandrita, Sherris, David, Prendergast, George C., Klagsbrun, Michael, Stuhlmann, Heidi, Rigby, Alan C., Nagy, Janice A., Benjamin, Laura E.
Published in Nature communications (27.11.2013)
Published in Nature communications (27.11.2013)
Get full text
Journal Article
Endothelial akt signaling is rate-limiting for rapamycin inhibition of mouse mammary tumor progression
PHUNG, Thuy L, EYIAH-MENSAH, Godfred, O'DONNELL, Rebekah K, BIENIEK, Radoslaw, SHECHTER, Sharon, WALSH, Kenneth, KUPERWASSER, Charlotte, BENJAMIN, Laura E
Published in Cancer research (Chicago, Ill.) (01.06.2007)
Published in Cancer research (Chicago, Ill.) (01.06.2007)
Get full text
Journal Article
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia
Lapalombella, Rosa, Sun, Qingxiang, Williams, Katie, Tangeman, Larissa, Jha, Shruti, Zhong, Yiming, Goettl, Virginia, Mahoney, Emilia, Berglund, Caroline, Gupta, Sneha, Farmer, Alicia, Mani, Rajeswaran, Johnson, Amy J., Lucas, David, Mo, Xiaokui, Daelemans, Dirk, Sandanayaka, Vincent, Shechter, Sharon, McCauley, Dilara, Shacham, Sharon, Kauffman, Michael, Chook, Yuh Min, Byrd, John C.
Published in Blood (29.11.2012)
Published in Blood (29.11.2012)
Get full text
Journal Article
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
SHACHAM SHARON, MCCAULEY DILARA, SHECHTER SHARON, SANDANAYAKA VINCENT P
Year of Publication 08.05.2024
Get full text
Year of Publication 08.05.2024
Patent
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
SHACHAM SHARON, MCCAULEY DILARA, SHECHTER SHARON, SANDANAYAKA VINCENT P
Year of Publication 27.03.2023
Get full text
Year of Publication 27.03.2023
Patent
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening
Thomas, David R., Lundberg, Lindsay, Pinkham, Chelsea, Shechter, Sharon, DeBono, Aaron, Baell, Jonathan, Wagstaff, Kylie M., Hick, Caroline A., Kehn-Hall, Kylene, Jans, David A.
Published in Antiviral research (01.03.2018)
Published in Antiviral research (01.03.2018)
Get full text
Journal Article
Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design
Shechter, Sharon, Thomas, David R., Lundberg, Lindsay, Pinkham, Chelsea, Lin, Shih-Chao, Wagstaff, Kylie M., Debono, Aaron, Kehn-Hall, Kylene, Jans, David A.
Published in Scientific reports (18.12.2017)
Published in Scientific reports (18.12.2017)
Get full text
Journal Article
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
SHACHAM SHARON, MCCAULEY DILARA, SHECHTER SHARON, SANDANAYAKA VINCENT P
Year of Publication 06.07.2021
Get full text
Year of Publication 06.07.2021
Patent
Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds
Crochiere, Marsha, Kashyap, Trinayan, Kalid, Ori, Shechter, Sharon, Klebanov, Boris, Senapedis, William, Saint-Martin, Jean-Richard, Landesman, Yosef
Published in BMC cancer (17.11.2015)
Published in BMC cancer (17.11.2015)
Get full text
Journal Article
Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity
DeBono, Aaron, Thomas, David R., Lundberg, Lindsay, Pinkham, Chelsea, Cao, Ying, Graham, J. Dinny, Clarke, Christine L., Wagstaff, Kylie M., Shechter, Sharon, Kehn-Hall, Kylene, Jans, David A.
Published in Scientific reports (22.02.2019)
Published in Scientific reports (22.02.2019)
Get full text
Journal Article
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
SHACHAM SHARON, MCCAULEY DILARA, SHECHTER SHARON, SANDANAYAKA VINCENT P
Year of Publication 22.07.2020
Get full text
Year of Publication 22.07.2020
Patent
Abstract LB-A20: True small molecule STING agonist generates systemic and potent anti-tumor immunity required for effective cancer immunotherapy
Kulkarni, Meghana M, Dwight, Timothy, Marino, Kristen, Allen, Bryce K, Taimi, Mohammed, Bastos, Cecilia, Lai, Sujen, Koh, Cheryl, Samant, Ramya, Tesar, Bethany, Huang, Huang, Chamberlain, Brian, Rice, James M, Tan, Dazhi, Lin, Zhixiong, Shechter, Sharon, Li, Stella, Sparks, Sam, Soutter, Holly, Swann, Steven, Sherman, Woody, Winter, Christopher
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
Get full text
Journal Article
Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design
Shechter, Sharon, Thomas, David R., Lundberg, Lindsay, Pinkham, Chelsea, Lin, Shih-Chao, Wagstaff, Kylie M., Debono, Aaron, Kehn-Hall, Kylene, Jans, David A.
Published in Scientific reports (04.09.2018)
Published in Scientific reports (04.09.2018)
Get full text
Journal Article
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
SHACHAM SHARON, MCCAULEY DILARA, SHECHTER SHARON, SANDANAYAKA VINCENT P
Year of Publication 02.05.2019
Get full text
Year of Publication 02.05.2019
Patent
RhoB Differentially Controls Akt Function in Tumor Cells and Stromal Endothelial Cells during Breast Tumorigenesis
KAZEROUNIAN, Shiva, GERALD, Damien, PHUNG, Thuy L, BRAVO-NUEVO, Arturo, SHECHTER, Sharon, MCNAMARA, Stephanie, DUHADAWAY, James B, KOCHER, Olivier N, BROWN, Lawrence F, TOKER, Alex, PRENDERGAST, George C, BENJAMIN, Laura E, MINZHOU HUANG, REBECCA CHIN, Y, UDAYAKUMAR, Durga, NINGNING ZHENG, O'DONNELL, Rebekah K, PERRUZZI, Carole, MANGIANTE, Lee, POURAT, Jacob
Published in Cancer research (Chicago, Ill.) (01.01.2013)
Published in Cancer research (Chicago, Ill.) (01.01.2013)
Get full text
Journal Article
NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
SHACHAM SHARON, MCCAULEY DILARA, SHECHTER SHARON, BALOGLU ERKAN, SANDANAYAKA VINCENT P
Year of Publication 14.10.2020
Get full text
Year of Publication 14.10.2020
Patent