Discovery of Highly Potent and Selective Small Molecule ADAMTS‑5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
Deng, Hongfeng, O’Keefe, Heather, Davie, Christopher P, Lind, Kenneth E, Acharya, Raksha A, Franklin, G. Joseph, Larkin, Jonathan, Matico, Rosalie, Neeb, Michael, Thompson, Monique M, Lohr, Thomas, Gross, Jeffrey W, Centrella, Paolo A, O’Donovan, Gary K, Bedard, Katie L. (Sargent), van Vloten, Kurt, Mataruse, Sibongile, Skinner, Steven R, Belyanskaya, Svetlana L, Carpenter, Tiffany Y, Shearer, Todd W, Clark, Matthew A, Cuozzo, John W, Arico-Muendel, Christopher C, Morgan, Barry A
Published in Journal of medicinal chemistry (23.08.2012)
Published in Journal of medicinal chemistry (23.08.2012)
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Journal Article
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model
Price, Daniel J., Drewry, David H., Schaller, Lee T., Thompson, Brian D., Reid, Paul R., Maloney, Patrick R., Liang, Xi, Banker, Periette, Buckholz, Richard G., Selley, Paula K., McDonald, Octerloney B., Smith, Jeffery L., Shearer, Todd W., Cox, Richard F., Williams, Shawn P., Reid, Robert A., Tacconi, Stefano, Faggioni, Federico, Piubelli, Chiara, Sartori, Ilaria, Tessari, Michela, Wang, Tony Y.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Journal Article
Total-body creatine pool size and skeletal muscle mass determination by creatine-(methyl-D3) dilution in rats
Stimpson, Stephen A, Turner, Scott M, Clifton, Lisa G, Poole, James C, Mohammed, Hussein A, Shearer, Todd W, Waitt, Greg M, Hagerty, Laura L, Remlinger, Katja S, Hellerstein, Marc K, Evans, William J
Published in Journal of applied physiology (1985) (01.06.2012)
Published in Journal of applied physiology (1985) (01.06.2012)
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Journal Article
Discovery of 4‑Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38
Becherer, J. David, Boros, Eric E., Carpenter, Tiffany Y., Cowan, David J., Deaton, David N., Haffner, Curt D., Jeune, Michael R., Kaldor, Istvan W., Poole, J. Chuck, Preugschat, Frank, Rheault, Tara R., Schulte, Christie A., Shearer, Barry G., Shearer, Todd W., Shewchuk, Lisa M., Smalley, Terrence L., Stewart, Eugene L., Stuart, J. Darren, Ulrich, John C.
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Journal Article
Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats
Shankaran, Mahalakshmi, Shearer, Todd W, Stimpson, Stephen A, Turner, Scott M, King, Chelsea, Wong, Po-Yin Anne, Shen, Ying, Turnbull, Philip S, Kramer, Fritz, Clifton, Lisa, Russell, Alan, Hellerstein, Marc K, Evans, William J
Published in American journal of physiology: endocrinology and metabolism (15.03.2016)
Published in American journal of physiology: endocrinology and metabolism (15.03.2016)
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Journal Article
Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists
Evans, Karen A, Budzik, Brian W, Ross, Sean A, Wisnoski, David D, Jin, Jian, Rivero, Ralph A, Vimal, Mythily, Szewczyk, George R, Jayawickreme, Channa, Moncol, David L, Rimele, Thomas J, Armour, Susan L, Weaver, Susan P, Griffin, Robert J, Tadepalli, Sarva M, Jeune, Michael R, Shearer, Todd W, Chen, Zibin B, Chen, Lihong, Anderson, Donald L, Becherer, J. David, De Los Frailes, Maite, Colilla, Francisco Javier
Published in Journal of medicinal chemistry (24.12.2009)
Published in Journal of medicinal chemistry (24.12.2009)
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Journal Article
Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D3-creatine dilution method
Stimpson, Stephen A., Leonard, Michael S., Clifton, Lisa G., Poole, James C., Turner, Scott M., Shearer, Todd W., Remlinger, Katja S., Clark, Richard V., Hellerstein, Marc K., Evans, William J.
Published in Journal of cachexia, sarcopenia and muscle (01.09.2013)
Published in Journal of cachexia, sarcopenia and muscle (01.09.2013)
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Journal Article
Identification and Characterization of 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist
Shearer, Barry G, Wiethe, Robert W, Ashe, Adam, Billin, Andrew N, Way, James M, Stanley, Thomas B, Wagner, Craig D, Xu, Robert X, Leesnitzer, Lisa M, Merrihew, Raymond V, Shearer, Todd W, Jeune, Michael R, Ulrich, John C, Willson, Timothy M
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
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Journal Article
Longitudinal changes in total body creatine pool size and skeletal muscle mass using the D 3 -creatine dilution method
Stimpson, Stephen A, Leonard, Michael S, Clifton, Lisa G, Poole, James C, Turner, Scott M, Shearer, Todd W, Remlinger, Katja S, Clark, Richard V, Hellerstein, Marc K, Evans, William J
Published in Journal of cachexia, sarcopenia and muscle (01.09.2013)
Published in Journal of cachexia, sarcopenia and muscle (01.09.2013)
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Journal Article
Adenosine A1 Receptor Modulation of MMP-2 Secretion by Trabecular Meshwork Cells
Shearer, Todd W, Crosson, Craig E
Published in Investigative ophthalmology & visual science (01.09.2002)
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Published in Investigative ophthalmology & visual science (01.09.2002)
Journal Article
Role of Specific Cytochrome P450 Isoforms in the Conversion of Phenoxypropoxybiguanide Analogs in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines
DIAZ, Damaris S, KOZAR, Michael. P, SMITH, Kirsten S, ASHER, Constance O, SOUSA, Jason C, SCHIEHSER, Guy A, JACOBUS, David. P, MILHOUS, Wilbur. K, SKILLMAN, Donald. R, SHEARER, Todd. W
Published in Drug metabolism and disposition (01.02.2008)
Published in Drug metabolism and disposition (01.02.2008)
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Journal Article
In Vitro Metabolism of Phenoxypropoxybiguanide Analogues in Human Liver Microsomes to Potent Antimalarial Dihydrotriazines
Shearer, Todd. W, Kozar, Michael. P, O'Neil, Michael T, Smith, Philip L, Schiehser, Guy A, Jacobus, David. P, Diaz, Damaris S, Yang, Young-Sun, Milhous, Wilbur. K, Skillman, Donald. R
Published in Journal of medicinal chemistry (21.04.2005)
Published in Journal of medicinal chemistry (21.04.2005)
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Journal Article
Pharmacokinetics, Safety, and Hydrolysis of Oral Pyrroloquinazolinediamines Administered in Single and Multiple Doses in Rats
QIGUI LI, KOZAR, Michael P, SKILLMAN, Donald R, SHEARER, Todd W, XIE, Lisa H, LIN, Ai J, SMITH, Kirsten S, YUANZHENG SI, ANOVA, Lalaine, JING ZHANG, MILHOUS, Wilbur K
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
Published in Antimicrobial Agents and Chemotherapy (01.08.2007)
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Journal Article
Trial in progress: A phase two trial of nirogacestat, a gamma-secretase inhibitor, in patients with recurrent ovarian granulosa cell tumors (NCT05348356) (1284)
Konstantinopoulos, Panagiotis, Lewis, Jocelyn, Shearer, Todd, Kaiser, Heather, Breitbach, Caroline, Cheng, Shinta
Published in Gynecologic oncology (01.09.2023)
Published in Gynecologic oncology (01.09.2023)
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Journal Article
Bradykinin enhancement of PGE2 signalling in bovine trabecular meshwork cells
WEBB, Jerry G, SHEARER, Todd W, YATES, Phillip W, MUKHIN, Yurii V, CROSSON, Craig E
Published in Experimental eye research (01.03.2003)
Published in Experimental eye research (01.03.2003)
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Journal Article
Population pharmacokinetic-pharmacodynamic model of nirogacestat effects on B-cell maturation antigen in healthy subjects
Shearer, Todd, Williams, Rex L., Johnson, Mark, Cendrowicz, Ewa, Leonowens, Cathrine, Smith, Margaret, Baughman, Todd, Breitbach, Caroline J., Smith, L. Mary, Cheng, Shinta
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Pharmacodynamic Effects of Nirogacestat, a Gamma Secretase Inhibitor, on B-Cell Maturation Antigen in Healthy Participants
Shearer, Todd, Williams, Rex L., Johnson, Mark, Cendrowicz, Ewa, Leonowens, Cathrine, Smith, Margaret, Baughman, Todd, Breitbach, Caroline J., Smith, L. Mary, Burgess, Michael, Cheng, Shinta
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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