Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)
Martin, Matthew W., Lancia, David R., Li, Hongbin, Schiller, Shawn E.R., Toms, Angela V., Wang, Zhongguo, Bair, Kenneth W., Castro, Jennifer, Fessler, Shawn, Gotur, Deepali, Hubbs, Stephen E., Kauffman, Goss S., Kershaw, Mark, Luke, George P., McKinnon, Crystal, Yao, Lili, Lu, Wei, Millan, David S.
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
Published in Bioorganic & medicinal chemistry letters (15.04.2019)
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Design and Optimization of Benzopiperazines as Potent Inhibitors of BET Bromodomains
Millan, David S, Kayser-Bricker, Katherine J, Martin, Matthew W, Talbot, Adam C, Schiller, Shawn E. R, Herbertz, Torsten, Williams, Grace L, Luke, George P, Hubbs, Stephen, Alvarez Morales, Monica A, Cardillo, Daniel, Troccolo, Paul, Mendes, Rachel L, McKinnon, Crystal
Published in ACS medicinal chemistry letters (10.08.2017)
Published in ACS medicinal chemistry letters (10.08.2017)
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Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin
Kuznetsov, Galina, TenDyke, Karen, Towle, Murray J, Cheng, Hongsheng, Liu, Junke, Marsh, Joanne P, Schiller, Shawn E R, Spyvee, Mark R, Yang, Hu, Seletsky, Boris M, Shaffer, Christina J, Marceau, Veronique, Yao, Ye, Suh, Edward M, Campagna, Silvio, Fang, Francis G, Kowalczyk, James J, Littlefield, Bruce A
Published in Molecular cancer therapeutics (01.10.2009)
Published in Molecular cancer therapeutics (01.10.2009)
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Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead, II
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Abstract 3079: FT-6876, a potent and selective inhibitor of CBP/p300 with antitumor activity in AR-positive breast cancer
Caligiuri, Maureen, Williams, Grace L., Castro, Jennifer, Battalagine, Linda, Muskiewicz, Kristina, Wilker, Erik, Yao, Lili, Schiller, Shawn, Toms, Angela, Li, Ping, Pardo, Eneida, Graves, Bradford, Wood, Kenneth W., Guichard, Sylvie M.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 1224: Discovery of novel BAF inhibitors for the treatment of transcription factor-driven cancers
Centore, Richard C., Soares, Luis M., Vaswani, Rishi G., Ichikawa, Kana, Li, Zhifang, Fan, Hong, Setser, Jeremy, Lahr, David L., Zawadzke, Laura, Chen, Xueying, Barnash, Kimberly D., Muwanguzi, Jordana, Anthony, Neville, Sandoval, Gabriel J., Feldman, Katharine, Adam, Ammar, Huang, David, Schiller, Shawn, Wilson, Kevin, Voigt, Johannes, Hentemann, Martin, Millan, David S., Chan, Ho Man, Bellon, Steven F., Decicco, Carl P., Xu, Lan
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
FT-6876, a Potent and Selective Inhibitor of CBP/p300, is Active in Preclinical Models of Androgen Receptor-Positive Breast Cancer
Caligiuri, Maureen, Williams, Grace L., Castro, Jennifer, Battalagine, Linda, Wilker, Erik, Yao, Lili, Schiller, Shawn, Toms, Angela, Li, Ping, Pardo, Eneida, Graves, Bradford, Azofeifa, Joey, Chicas, Agustin, Herbertz, Torsten, Lai, Maria, Basken, Joel, Wood, Kenneth W., Xu, Qunli, Guichard, Sylvie M.
Published in Targeted oncology (01.03.2023)
Published in Targeted oncology (01.03.2023)
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Journal Article
Abstract 6064: Discovery of potent and selective EP300 degraders with anti-cancer activity
Zimmerman, Mark, Adam, Ammar, Ahmad, Hafiz, Adams, Benjamin, Adhikari, Ketaki, Austin, Wesley, Bullock, Breanna, Bernardo, Julie Di, Dixon, Thomas, Daniels, Danette, Dominici, Claudia, Elliot, GiNell, Ethell, Brian, Gervais, Anais, Hossain, Md Imran, Huang, David, Lahr, Dave, Lin, Mei Yun, Mayhew, David, Mizeracka, Karolina, Negretti, Solymar, Nguyen, Tyler, Prifti, Olga, Sappal, Darshan, Schiller, Shawn, Sherbanee, Brenna, Terry, David, Ucisik, Nihan, Wittenborn, Elizabeth, Zhou, Qianhe, La Bonte, Laura
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 6067: Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications
Sappal, Darshan, Adam, Ammar, Ahmad, Hafiz, Adams, Benjamin, Adhikari, Ketaki, Austin, Wesley, Bullock, Breanna, Bernardo, Julie Di, Dixon, Thomas, Daniels, Danette, Dominici, Claudia, Elliot, GiNell, Ethell, Brian, Gervais, Anais, Hossain, Md Imran, Huang, David, Lahr, Dave, Lin, Mei Yun, Mayhew, David, Mizeracka, Karolina, Negretti, Solymar, Nguyen, Tyler, Prifti, Olga, Schiller, Shawn, Sherbanee, Brenna, Terry, David, Ucisik, Nihan, Wittenborn, Elizabeth, Zhou, Qianhe, Zimmerman, Mark, La Bonte, Laura
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract A060: Discovery of potent and selective EP300 degraders with anti-cancer activity
Zimmerman, Mark, Sappal, Darshan, Adam, Ammar, Adams, Benjamin, Adhikari, Ketaki, Austin, Wesley, Bullock, Breanna, DiBernardo, Julie, Dixon, Thomas, Elliot, GiNell, Ethell, Brian, Gervais, Anais, Hossain, Md Imran, Huang, David, Lahr, Dave, Lin, Mei Yun, Mayhew, David, Mizeracka, Karolina, Negretti, Solymar, Nguyen, Tyler, Prifti, Olga, Schiller, Shawn, Sherbanee, Brenna, Terry, David, Ucisik, Nihan, Wittenborn, Elizabeth, LaBonte, Laura, Daniels, Danette
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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FT-1101: A Structurally Distinct Pan-BET Bromodomain Inhibitor with Activity in Preclinical Models of Hematologic Malignancies
Millan, David S, Alvarez Morales, Monica A, Barr, Kenneth J, Cardillo, Daniel, Collis, Alan, Dinsmore, Christopher J, Escobedo, Jaime A, Foley, Kevin P, Herbertz, Torsten, Hubbs, Stephen, Kauffman, Goss S, Kayser-Bricker, Katherine J, Kershaw, Mark T, Luke, George P, Martin, Matthew W, McKinnon, Crystal, Mendes, Rachel L, Muskiewicz, Kristina R, Schiller, Shawn ER, Soulard, Patricia, Talbot, Adam C, Walker, Duncan, Yao, Lili, Williams, Grace L
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
HANS HANSEN, LYNN HAWKINS, HEATHER DAVIS, SALLY ISHIZAKA, SHAWN SCHILLER, MATTHEW MACKEY, ERIC CARLSON, OGAWA CHIKAKO, ENDO ATSUSHI
Year of Publication 14.02.2019
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Year of Publication 14.02.2019
Patent
SELECTIVELY SUBSTITUTED QUINOLINE COMPOUNDS
HANS HANSEN, LYNN HAWKINS, HEATHER DAVIS, SALLY ISHIZAKA, SHAWN SCHILLER, MATTHEW MACKEY, ERIC CARLSON, OGAWA CHIKAKO, ENDO ATSUSHI
Year of Publication 28.12.2017
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Year of Publication 28.12.2017
Patent
TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS
ROCH BOIVIN, HANS HANSEN, SATO TAKASHI, SRIDHAR NARAYAN, LYNN D HAWKINS, SALLY ISHIZAKA, SHAWN SCHILLER, MATTHEW MACKEY, ERIC CARLSON, ENDO ATSUSHI
Year of Publication 07.06.2018
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Year of Publication 07.06.2018
Patent
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2
Shen, Yongchun, Boivin, Roch, Yoneda, Naoki, Du, Hong, Schiller, Shawn, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Lemelin, Charles, Jiang, Yimin, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Schnaderbeck, Matthew, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Journal Article
Discovery of an in vitro and in vivo potent resorcylic lactone analog of LL-Z1640-2 as anti-inflammatory lead
Shen, Yongchun, Du, Hong, Kotake, Makoto, Matsushima, Tomohiro, Goto, Masaki, Shirota, Hiroshi, Gusovsky, Fabian, Li, Xiangyi, Jiang, Yimin, Schiller, Shawn, Spyvee, Mark, Davis, Heather, Zhang, Zhiyi, Pelletier, Robert, Ikemori-Kawada, Megumi, Kawakami, Yoshiyuki, Inoue, Atsushi, Wang, Yuan
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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