Oxysterols: From physiological tuners to pharmacological opportunities
Brown, Andrew J., Sharpe, Laura J., Rogers, Michael J.
Published in British journal of pharmacology (01.08.2021)
Published in British journal of pharmacology (01.08.2021)
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Journal Article
Oxysterols: Old Tale, New Twists
Luu, Winnie, Sharpe, Laura J, Capell-Hattam, Isabelle, Gelissen, Ingrid C, Brown, Andrew J
Published in Annual review of pharmacology and toxicology (06.01.2016)
Published in Annual review of pharmacology and toxicology (06.01.2016)
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Journal Article
Desmosterol and DHCR24: Unexpected new directions for a terminal step in cholesterol synthesis
Zerenturk, Eser J., Sharpe, Laura J., Ikonen, Elina, Brown, Andrew J.
Published in Progress in lipid research (01.10.2013)
Published in Progress in lipid research (01.10.2013)
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Journal Article
Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation
Sharpe, Laura J., Howe, Vicky, Scott, Nicola A., Luu, Winnie, Phan, Lisa, Berk, Jason M., Hochstrasser, Mark, Brown, Andrew J.
Published in The Journal of biological chemistry (15.02.2019)
Published in The Journal of biological chemistry (15.02.2019)
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Journal Article
The UPS and downs of cholesterol homeostasis
Sharpe, Laura J., Cook, Emma C.L., Zelcer, Noam, Brown, Andrew J.
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.11.2014)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01.11.2014)
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Journal Article
Cholesterol synthesis enzyme SC4MOL is fine-tuned by sterols and targeted for degradation by the E3 ligase MARCHF6
Qian, Lydia, Scott, Nicola A., Capell-Hattam, Isabelle M., Draper, Eliza A., Fenton, Nicole M., Luu, Winnie, Sharpe, Laura J., Brown, Andrew J.
Published in Journal of lipid research (01.05.2023)
Published in Journal of lipid research (01.05.2023)
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Journal Article
Akt acutely activates the cholesterogenic transcription factor SREBP-2
Luu, Winnie, Sharpe, Laura J., Stevenson, Julian, Brown, Andrew J.
Published in Biochimica et biophysica acta (01.02.2012)
Published in Biochimica et biophysica acta (01.02.2012)
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Journal Article
The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters
Aleidi, Shereen M., Howe, Vicky, Sharpe, Laura J., Yang, Alryel, Rao, Geetha, Brown, Andrew J., Gelissen, Ingrid C.
Published in The Journal of biological chemistry (02.10.2015)
Published in The Journal of biological chemistry (02.10.2015)
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Journal Article
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]
Luu, Winnie, Zerenturk, Eser J., Kristiana, Ika, Bucknall, Martin P., Sharpe, Laura J., Brown, Andrew J.
Published in Journal of lipid research (01.03.2014)
Published in Journal of lipid research (01.03.2014)
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Journal Article
Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt
Kockx, Maaike, Dinnes, Donna L, Huang, Kuan-Yen, Sharpe, Laura J, Jessup, Wendy, Brown, Andrew J, Kritharides, Leonard
Published in Biochemical journal (01.10.2012)
Published in Biochemical journal (01.10.2012)
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Journal Article
Norovirus RNA-Dependent RNA Polymerase Is Phosphorylated by an Important Survival Kinase, Akt
EDEN, John-Sebastian, SHARPE, Laura J, WHITE, Peter A, BROWN, Andrew J
Published in Journal of Virology (01.10.2011)
Published in Journal of Virology (01.10.2011)
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Journal Article
Protein kinase A modulates the activity of a major human isoform of ABCG1
Gelissen, Ingrid C., Sharpe, Laura J., Sandoval, Cecilia, Rao, Geetha, Kockx, Maaike, Kritharides, Leonard, Jessup, Wendy, Brown, Andrew J.
Published in Journal of lipid research (01.10.2012)
Published in Journal of lipid research (01.10.2012)
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Journal Article
Post-translational control of the long and winding road to cholesterol
Sharpe, Laura J., Coates, Hudson W., Brown, Andrew J.
Published in The Journal of biological chemistry (18.12.2020)
Published in The Journal of biological chemistry (18.12.2020)
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Journal Article
New insights into cellular cholesterol acquisition: promoter analysis of human HMGCR and SQLE, two key control enzymes in cholesterol synthesis
Howe, Vicky, Sharpe, Laura J., Prabhu, Anika V., Brown, Andrew J.
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.07.2017)
Published in Biochimica et biophysica acta. Molecular and cell biology of lipids (01.07.2017)
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