NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
Eccles, Suzanne A, Massey, Andy, Raynaud, Florence I, Sharp, Swee Y, Box, Gary, Valenti, Melanie, Patterson, Lisa, de Haven Brandon, Alexis, Gowan, Sharon, Boxall, Frances, Aherne, Wynne, Rowlands, Martin, Hayes, Angela, Martins, Vanessa, Urban, Frederique, Boxall, Kathy, Prodromou, Chrisostomos, Pearl, Laurence, James, Karen, Matthews, Thomas P, Cheung, Kwai-Ming, Kalusa, Andrew, Jones, Keith, McDonald, Edward, Barril, Xavier, Brough, Paul A, Cansfield, Julie E, Dymock, Brian, Drysdale, Martin J, Finch, Harry, Howes, Rob, Hubbard, Roderick E, Surgenor, Alan, Webb, Paul, Wood, Mike, Wright, Lisa, Workman, Paul
Published in Cancer research (Chicago, Ill.) (15.04.2008)
Published in Cancer research (Chicago, Ill.) (15.04.2008)
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Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
HOLMES, Joanna L, SHARP, Swee Y, HOBBS, Steve, WORKMAN, Paul
Published in Cancer research (Chicago, Ill.) (15.02.2008)
Published in Cancer research (Chicago, Ill.) (15.02.2008)
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4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
Brough, Paul A, Aherne, Wynne, Barril, Xavier, Borgognoni, Jenifer, Boxall, Kathy, Cansfield, Julie E, Cheung, Kwai-Ming J, Collins, Ian, Davies, Nicholas G. M, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Finch, Harry, Fink, Alexandra, Hayes, Angela, Howes, Robert, Hubbard, Roderick E, James, Karen, Jordan, Allan M, Lockie, Andrea, Martins, Vanessa, Massey, Andrew, Matthews, Thomas P, McDonald, Edward, Northfield, Christopher J, Pearl, Laurence H, Prodromou, Chrisostomos, Ray, Stuart, Raynaud, Florence I, Roughley, Stephen D, Sharp, Swee Y, Surgenor, Allan, Walmsley, D. Lee, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa
Published in Journal of medicinal chemistry (24.01.2008)
Published in Journal of medicinal chemistry (24.01.2008)
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Combining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
Brough, Paul A, Barril, Xavier, Borgognoni, Jenifer, Chene, Patrick, Davies, Nicholas G. M, Davis, Ben, Drysdale, Martin J, Dymock, Brian, Eccles, Suzanne A, Garcia-Echeverria, Carlos, Fromont, Christophe, Hayes, Angela, Hubbard, Roderick E, Jordan, Allan M, Jensen, Michael Rugaard, Massey, Andrew, Merrett, Angela, Padfield, Antony, Parsons, Rachel, Radimerski, Thomas, Raynaud, Florence I, Robertson, Alan, Roughley, Stephen D, Schoepfer, Joseph, Simmonite, Heather, Sharp, Swee Y, Surgenor, Allan, Valenti, Melanie, Walls, Steven, Webb, Paul, Wood, Mike, Workman, Paul, Wright, Lisa
Published in Journal of medicinal chemistry (13.08.2009)
Published in Journal of medicinal chemistry (13.08.2009)
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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen
Cheeseman, Matthew D, Chessum, Nicola E. A, Rye, Carl S, Pasqua, A. Elisa, Tucker, Michael J, Wilding, Birgit, Evans, Lindsay E, Lepri, Susan, Richards, Meirion, Sharp, Swee Y, Ali, Salyha, Rowlands, Martin, O’Fee, Lisa, Miah, Asadh, Hayes, Angela, Henley, Alan T, Powers, Marissa, te Poele, Robert, De Billy, Emmanuel, Pellegrino, Loredana, Raynaud, Florence, Burke, Rosemary, van Montfort, Rob L. M, Eccles, Suzanne A, Workman, Paul, Jones, Keith
Published in Journal of medicinal chemistry (12.01.2017)
Published in Journal of medicinal chemistry (12.01.2017)
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Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma
Gaspar, Nathalie, Sharp, Swee Y, Eccles, Suzanne A, Gowan, Sharon, Popov, Sergey, Jones, Chris, Pearson, Andrew, Vassal, Gilles, Workman, Paul
Published in Molecular cancer therapeutics (01.05.2010)
Published in Molecular cancer therapeutics (01.05.2010)
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Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues
Sharp, Swee Y, Prodromou, Chrisostomos, Boxall, Kathy, Powers, Marissa V, Holmes, Joanna L, Box, Gary, Matthews, Thomas P, Cheung, Kwai-Ming J, Kalusa, Andrew, James, Karen, Hayes, Angela, Hardcastle, Anthea, Dymock, Brian, Brough, Paul A, Barril, Xavier, Cansfield, Julie E, Wright, Lisa, Surgenor, Allan, Foloppe, Nicolas, Hubbard, Roderick E, Aherne, Wynne, Pearl, Laurence, Jones, Keith, McDonald, Edward, Raynaud, Florence, Eccles, Sue, Drysdale, Martin, Workman, Paul
Published in Molecular cancer therapeutics (01.04.2007)
Published in Molecular cancer therapeutics (01.04.2007)
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Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors
Sharp, Swee Y, Roe, S Mark, Kazlauskas, Egidijus, Cikotienė, Inga, Workman, Paul, Matulis, Daumantas, Prodromou, Chrisostomos
Published in PloS one (11.09.2012)
Published in PloS one (11.09.2012)
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In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors
SHARP, Swee Y, BOXALL, Kathy, PATTERSON, Lisa, MATTHEWS, Thomas P, CHEUNG, Kwai-Ming J, BALL, Karen, HAYES, Angela, RAYNAUD, Florence, MARAIS, Richard, PEARL, Laurence, ECCLES, Sue, AHERNE, Wynne, ROWLANDS, Martin, MCDONALD, Edward, WORKMAN, Paul, PRODROMOU, Chrisostomos, ROE, S. Mark, MALONEY, Alison, POWERS, Marissa, CLARKE, Paul A, BOX, Gary, SANDERSON, Sharon
Published in Cancer research (Chicago, Ill.) (01.03.2007)
Published in Cancer research (Chicago, Ill.) (01.03.2007)
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Inhibition of Hsp90 with Resorcylic Acid Macrolactones: Synthesis and Binding Studies
Day, James E. H., Sharp, Swee Y., Rowlands, Martin G., Aherne, Wynne, Lewis, William, Roe, S. Mark, Prodromou, Chrisostomos, Pearl, Laurence H., Workman, Paul, Moody, Christopher J.
Published in Chemistry : a European journal (10.09.2010)
Published in Chemistry : a European journal (10.09.2010)
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Journal Article
Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766)
Chessum, Nicola E. A, Sharp, Swee Y, Caldwell, John J, Pasqua, A. Elisa, Wilding, Birgit, Colombano, Giampiero, Collins, Ian, Ozer, Bugra, Richards, Meirion, Rowlands, Martin, Stubbs, Mark, Burke, Rosemary, McAndrew, P. Craig, Clarke, Paul A, Workman, Paul, Cheeseman, Matthew D, Jones, Keith
Published in Journal of medicinal chemistry (08.02.2018)
Published in Journal of medicinal chemistry (08.02.2018)
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Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Holmes, Joanna L, Sharp, Swee Y, Hobbs, Steve, Workman, Paul
Published in Cancer research (Chicago, Ill.) (01.01.2019)
Published in Cancer research (Chicago, Ill.) (01.01.2019)
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Journal Article
Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells
Davenport, Emma L., Moore, Hannah E., Dunlop, Alan S., Sharp, Swee Y., Workman, Paul, Morgan, Gareth J., Davies, Faith E.
Published in Blood (01.10.2007)
Published in Blood (01.10.2007)
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Journal Article
Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy
Rodrigues, Loreta M, Chung, Yuen-Li, Al Saffar, Nada M S, Sharp, Swee Y, Jackson, Laura E, Banerji, Udai, Stubbs, Marion, Leach, Martin O, Griffiths, John R, Workman, Paul
Published in BMC research notes (23.05.2012)
Published in BMC research notes (23.05.2012)
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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies
Pasqua, A. Elisa, Sharp, Swee Y., Chessum, Nicola E. A., Hayes, Angela, Pellegrino, Loredana, Tucker, Michael J., Miah, Asadh, Wilding, Birgit, Evans, Lindsay E., Rye, Carl S., Mok, N. Yi, Liu, Manjuan, Henley, Alan T., Gowan, Sharon, De Billy, Emmanuel, te Poele, Robert, Powers, Marissa, Eccles, Suzanne A., Clarke, Paul A., Raynaud, Florence I., Workman, Paul, Jones, Keith, Cheeseman, Matthew D.
Published in Journal of medicinal chemistry (27.04.2023)
Published in Journal of medicinal chemistry (27.04.2023)
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MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature
Gaspar, Nathalie, Marshall, Lynley, Perryman, Lara, Bax, Dorine A., Little, Suzanne E., Pereira, Marta Sofia Carvalho Ribeiro Viana, Sharp, Swee Y., Vassal, Gilles, Pearson, Andrew D. J., Reis, R. M., Hargrave, Darren, Workman, Paul, Jones, Chris
Published in Cancer research (Chicago, Ill.) (15.11.2010)
Published in Cancer research (Chicago, Ill.) (15.11.2010)
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Acquired Resistance to 17-Allylamino-17-Demethoxygeldanamycin (17-AAG, Tanespimycin) in Glioblastoma Cells
GASPAR, Nathalie, SHARP, Swee Y, PACEY, Simon, JONES, Chris, WALTON, Michael, VASSAL, Gilles, ECCLES, Suzanne, PARSON, Andrew, WORKMAN, Paul
Published in Cancer research (Chicago, Ill.) (01.03.2009)
Published in Cancer research (Chicago, Ill.) (01.03.2009)
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Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines
Patel, Alpa, Sharp, Swee Y., Hall, Katelan, Lewis, William, Stevens, Malcolm F. G., Workman, Paul, Moody, Christopher J.
Published in Organic & biomolecular chemistry (28.04.2016)
Published in Organic & biomolecular chemistry (28.04.2016)
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