Genomic and molecular characterization of esophageal squamous cell carcinoma
Lin, De-Chen, Hao, Jia-Jie, Nagata, Yasunobu, Xu, Liang, Shang, Li, Meng, Xuan, Sato, Yusuke, Okuno, Yusuke, Varela, Ana Maria, Ding, Ling-Wen, Garg, Manoj, Liu, Li-Zhen, Yang, Henry, Yin, Dong, Shi, Zhi-Zhou, Jiang, Yan-Yi, Gu, Wen-Yue, Gong, Ting, Zhang, Yu, Xu, Xin, Kalid, Ori, Shacham, Sharon, Ogawa, Seishi, Wang, Ming-Rong, Koeffler, H Phillip
Published in Nature genetics (01.05.2014)
Published in Nature genetics (01.05.2014)
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Nucleo-cytoplasmic transport as a therapeutic target of cancer
Gravina, Giovanni Luca, Senapedis, William, McCauley, Dilara, Baloglu, Erkan, Shacham, Sharon, Festuccia, Claudio
Published in Journal of hematology and oncology (05.12.2014)
Published in Journal of hematology and oncology (05.12.2014)
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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action
Campaner, Elena, Rustighi, Alessandra, Zannini, Alessandro, Cristiani, Alberto, Piazza, Silvano, Ciani, Yari, Kalid, Ori, Golan, Gali, Baloglu, Erkan, Shacham, Sharon, Valsasina, Barbara, Cucchi, Ulisse, Pippione, Agnese Chiara, Lolli, Marco Lucio, Giabbai, Barbara, Storici, Paola, Carloni, Paolo, Rossetti, Giulia, Benvenuti, Federica, Bello, Ezia, D’Incalci, Maurizio, Cappuzzello, Elisa, Rosato, Antonio, Del Sal, Giannino
Published in Nature communications (09.06.2017)
Published in Nature communications (09.06.2017)
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Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia
Ranganathan, Parvathi, Yu, Xueyan, Na, Caroline, Santhanam, Ramasamy, Shacham, Sharon, Kauffman, Michael, Walker, Alison, Klisovic, Rebecca, Blum, William, Caligiuri, Michael, Croce, Carlo M., Marcucci, Guido, Garzon, Ramiro
Published in Blood (30.08.2012)
Published in Blood (30.08.2012)
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Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3 -mutated acute myeloid leukemias: from concept to clinical trial
Zhang, Weiguo, Ly, Charlie, Ishizawa, Jo, Mu, Hong, Ruvolo, Vivian, Shacham, Sharon, Daver, Naval, Andreeff, Michael
Published in Haematologica (Roma) (01.10.2018)
Published in Haematologica (Roma) (01.10.2018)
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Induction of p53‐mediated transcription and apoptosis by exportin‐1 (XPO1) inhibition in mantle cell lymphoma
Yoshimura, Mariko, Ishizawa, Jo, Ruvolo, Vivian, Dilip, Archana, Quintás‐Cardama, Alfonso, McDonnell, Timothy J., Neelapu, Sattva S., Kwak, Larry W., Shacham, Sharon, Kauffman, Michael, Tabe, Yoko, Yokoo, Masako, Kimura, Shinya, Andreeff, Michael, Kojima, Kensuke
Published in Cancer science (01.07.2014)
Published in Cancer science (01.07.2014)
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Journal Article
Prognostic impact and targeting of CRM1 in acute myeloid leukemia
Kojima, Kensuke, Kornblau, Steven M., Ruvolo, Vivian, Dilip, Archana, Duvvuri, Seshagiri, Davis, R. Eric, Zhang, Min, Wang, Zhiqiang, Coombes, Kevin R., Zhang, Nianxiang, Qiu, Yi Hua, Burks, Jared K., Kantarjian, Hagop, Shacham, Sharon, Kauffman, Michael, Andreeff, Michael
Published in Blood (16.05.2013)
Published in Blood (16.05.2013)
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Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor
Subhash, Vinod Vijay, Yeo, Mei Shi, Wang, Lingzhi, Tan, Shi Hui, Wong, Foong Ying, Thuya, Win Lwin, Tan, Woei Loon, Peethala, Praveen C., Soe, Mu Yar, Tan, David S. P., Padmanabhan, Nisha, Baloglu, Erkan, Shacham, Sharon, Tan, Patrick, Koeffler, H. Phillip, Yong, Wei Peng
Published in Scientific reports (16.08.2018)
Published in Scientific reports (16.08.2018)
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Journal Article
Selective Inhibitors of Nuclear Export Block Pancreatic Cancer Cell Proliferation and Reduce Tumor Growth in Mice
Azmi, Asfar S, Aboukameel, Amro, Bao, Bin, Sarkar, Fazlul H, Philip, Philip A, Kauffman, Michael, Shacham, Sharon, Mohammad, Ramzi M
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.02.2013)
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Journal Article
XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer
Cheng, Yan, Holloway, Michael P, Nguyen, Kevin, McCauley, Dilara, Landesman, Yosef, Kauffman, Michael G, Shacham, Sharon, Altura, Rachel A
Published in Molecular cancer therapeutics (01.03.2014)
Published in Molecular cancer therapeutics (01.03.2014)
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Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination
Haines, Jeffery D, Herbin, Olivier, de la Hera, Belén, Vidaurre, Oscar G, Moy, Gregory A, Sun, Qingxiang, Fung, Ho Yee Joyce, Albrecht, Stefanie, Alexandropoulos, Konstantina, McCauley, Dilara, Chook, Yuh Min, Kuhlmann, Tanja, Kidd, Grahame J, Shacham, Sharon, Casaccia, Patrizia
Published in Nature neuroscience (01.04.2015)
Published in Nature neuroscience (01.04.2015)
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Journal Article
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias
Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo
Published in Blood (24.10.2013)
Published in Blood (24.10.2013)
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The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia
Vercruysse, Thomas, De Bie, Jolien, Neggers, Jasper E, Jacquemyn, Maarten, Vanstreels, Els, Schmid-Burgk, Jonathan L, Hornung, Veit, Baloglu, Erkan, Landesman, Yosef, Senapedis, William, Shacham, Sharon, Dagklis, Antonis, Cools, Jan, Daelemans, Dirk
Published in Clinical cancer research (15.05.2017)
Published in Clinical cancer research (15.05.2017)
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Consensus Induced Fit Docking (cIFD): methodology, validation, and application to the discovery of novel Crm1 inhibitors
Kalid, Ori, Toledo Warshaviak, Dora, Shechter, Sharon, Sherman, Woody, Shacham, Sharon
Published in Journal of computer-aided molecular design (01.11.2012)
Published in Journal of computer-aided molecular design (01.11.2012)
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Journal Article
Antiviral Efficacy of Verdinexor In Vivo in Two Animal Models of Influenza A Virus Infection
Perwitasari, Olivia, Johnson, Scott, Yan, Xiuzhen, Register, Emery, Crabtree, Jackelyn, Gabbard, Jon, Howerth, Elizabeth, Shacham, Sharon, Carlson, Robert, Tamir, Sharon, Tripp, Ralph A
Published in PloS one (28.11.2016)
Published in PloS one (28.11.2016)
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Oral eltanexor treatment of patients with higher-risk myelodysplastic syndrome refractory to hypomethylating agents
Lee, Sangmin, Mohan, Sanjay, Knupp, Jessica, Chamoun, Kamal, de Jonge, Adrienne, Yang, Fan, Baloglu, Erkan, Shah, Jatin, Kauffman, Michael G, Shacham, Sharon, Bhatnagar, Bhavana
Published in Journal of hematology and oncology (03.08.2022)
Published in Journal of hematology and oncology (03.08.2022)
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Journal Article
Novel selective inhibitors of nuclear export CRM1 antagonists for therapy in mantle cell lymphoma
Zhang, Kejie, Wang, Michael, Tamayo, Archito T, Shacham, Sharon, Kauffman, Michael, Lee, John, Zhang, Liang, Ou, Zhishuo, Li, Changping, Sun, Luhong, Ford, Richard J, Pham, Lan V
Published in Experimental hematology (2013)
Published in Experimental hematology (2013)
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