Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids
Tian, Xiaochen, Xuan, Tengfei, Gao, Jingkun, Zhang, Xinyu, Liu, Tao, Luo, Fengbiao, Pang, Ruochen, Shao, Pengcheng, Yang, Yun-Fang, Wang, Yang
Published in Nature communications (31.07.2024)
Published in Nature communications (31.07.2024)
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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties
Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP‑4 Inhibition
Liu, Weiguo, Shao, Pengcheng P, Liang, Gui-Bai, Bawiec, John, He, Jiafang, Aster, Susan D, Wu, Margaret, Chicchi, Garry, Wang, John, Tsao, Kwei-Lan, Shang, Jin, Salituro, Gino, Zhou, Yun-Ping, Li, Cai, Akiyama, Taro E, Metzger, Daniel E, Murphy, Beth Ann, Howard, Andrew D, Weber, Ann E, Duffy, Joseph L
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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Aminopiperidine Sulfonamide Cav2.2 Channel Inhibitors for the Treatment of Chronic Pain
Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Varughese, Deepu J, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L
Published in Journal of medicinal chemistry (26.11.2012)
Published in Journal of medicinal chemistry (26.11.2012)
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Toward the Development of a General Chiral Auxiliary. A Total Synthesis of (+)-Tetronolide via a Tandem Ketene-Trapping [4 + 2] Cycloaddition Strategy
Boeckman, Robert K, Shao, Pengcheng, Wrobleski, Stephen T, Boehmler, Debra J, Heintzelman, Geoffrey R, Barbosa, Antonio. J
Published in Journal of the American Chemical Society (16.08.2006)
Published in Journal of the American Chemical Society (16.08.2006)
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Block of Peripheral Nerve Sodium Channels Selectively Inhibits Features of Neuropathic Pain in Rats
Brochu, Richard M, Dick, Ivy E, Tarpley, Jason W, McGowan, Erin, Gunner, David, Herrington, James, Shao, Pengcheng P, Ok, Dong, Li, Chunshi, Parsons, William H, Stump, Gary L, Regan, Christopher P, Lynch, Jr, Joseph J, Lyons, Kathryn A, McManus, Owen B, Clark, Samantha, Ali, Zahid, Kaczorowski, Gregory J, Martin, William J, Priest, Birgit T
Published in Molecular pharmacology (01.03.2006)
Published in Molecular pharmacology (01.03.2006)
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Improved Cav2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide
Shao, Pengcheng P, Ye, Feng, Chakravarty, Prasun K, Herrington, James B, Dai, Ge, Bugianesi, Randal M, Haedo, Rodolfo J, Swensen, Andrew M, Warren, Vivien A, Smith, McHardy M, Garcia, Maria L, McManus, Owen B, Lyons, Kathryn A, Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J, Duffy, Joseph L
Published in ACS medicinal chemistry letters (14.11.2013)
Published in ACS medicinal chemistry letters (14.11.2013)
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Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain
Shao, Pengcheng P., Ye, Feng, Weber, Ann E., Li, Xiaohua, Lyons, Kathryn A., Parsons, William H., Garcia, Maria L., Priest, Birgit T., Smith, McHardy M., Felix, John P., Williams, Brande S., Kaczorowski, Gregory J., McGowan, Erin, Abbadie, Catherine, Martin, William J., McMasters, Daniel R., Gao, Ying-Duo
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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Discovery of a novel class of isoxazoline voltage gated sodium channel blockers
Shao, Pengcheng P., Ye, Feng, Weber, Ann E., Li, Xiaohua, Lyons, Kathryn A., Parsons, William H., Garcia, Maria L., Priest, Birgit T., Smith, McHardy M., Felix, John P., Williams, Brande S., Kaczorowski, Gregory J., McGowan, Erin, Abbadie, Catherine, Martin, William J., McMasters, Daniel R., Gao, Ying-Duo
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
Published in Bioorganic & medicinal chemistry letters (15.09.2009)
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A Disubstituted Succinamide Is a Potent Sodium Channel Blocker with Efficacy in a Rat Pain Model
Priest, Birgit T, Garcia, Maria L, Middleton, Richard E, Brochu, Richard M, Clark, Samantha, Dai, Ge, Dick, Ivy E, Felix, John P, Liu, Chou J, Reiseter, Brita S, Schmalhofer, William A, Shao, Pengcheng P, Tang, Yui S, Chou, Margaret Z, Kohler, Martin G, Smith, McHardy M, Warren, Vivien A, Williams, Brande S, Cohen, Charles J, Martin, William J, Meinke, Peter T, Parsons, William H, Wafford, Keith A, Kaczorowski, Gregory J
Published in Biochemistry (Easton) (03.08.2004)
Published in Biochemistry (Easton) (03.08.2004)
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