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Published in British journal of pharmacology (01.08.2015)
Published in British journal of pharmacology (01.08.2015)
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An assay to evaluate the long‐term effects of inflammatory mediators on murine airway smooth muscle: evidence that TNFα up‐regulates 5‐HT 2A ‐mediated contraction
Adner, Mikael, Rose, Andrew C, Zhang, Yaping, Swärd, Karl, Benson, Mikael, Uddman, Rolf, Shankley, Nigel P, Cardell, Lars‐Olaf
Published in British journal of pharmacology (02.02.2009)
Published in British journal of pharmacology (02.02.2009)
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Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor
Barrett, Terrance D, Palomino, Heather L, Brondstetter, Theresa I, Kanelakis, Kimon C, Wu, Xiaodong, Haug, Peter V, Yan, Wen, Young, Andrew, Hua, Hong, Hart, Juliet C, Tran, Da-Thao, Venkatesan, Hariharan, Rosen, Mark D, Peltier, Hillary M, Sepassi, Kia, Rizzolio, Michele C, Bembenek, Scott D, Mirzadegan, Tara, Rabinowitz, Michael H, Shankley, Nigel P
Published in Molecular pharmacology (01.06.2011)
Published in Molecular pharmacology (01.06.2011)
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Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs
Bhattacharya, Anindya, Scott, Brian P, Nasser, Nadia, Ao, Hong, Maher, Michael P, Dubin, Adrienne E, Swanson, Devin M, Shankley, Nigel P, Wickenden, Alan D, Chaplan, Sandra R
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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The scientific legacy of Sir James W. Black
Page, Clive P, Schaffhausen, Joanna, Shankley, Nigel P
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2011)
Published in Trends in pharmacological sciences (Regular ed.) (01.04.2011)
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Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2α (HRI) kinase
Rosen, Mark D., Woods, Craig R., Goldberg, Steven D., Hack, Michael D., Bounds, A. Dawn, Yang, Young, Wagaman, Pamela C., Phuong, Victor K., Ameriks, Angela P., Barrett, Terrance D., Kanelakis, Kimon C., Chang, Jui, Shankley, Nigel P., Rabinowitz, Michael H.
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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TNF α reduces tachykinin, PGE 2 ‐dependent, relaxation of the cultured mouse trachea by increasing the activity of COX‐2
Bachar, Ofir, Rose, Andrew C, Adner, Mikael, Wang, Xudong, Prendergast, Clodagh E, Kempf, Ashley, Shankley, Nigel P, Cardell, Lars‐Olaf
Published in British journal of pharmacology (29.01.2009)
Published in British journal of pharmacology (29.01.2009)
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JNJ-26070109 [(R)4-bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: a novel, potent, and selective cholecystokinin 2 receptor antagonist with good oral bioavailability
Morton, Magda F, Barrett, Terrance D, Freedman, Jamie, Li, Lina, Rizzolio, Michele C, Prendergast, Clodagh E, Wu, Xiaodong, Moreno, Veronica, Pyati, Jayashree, Figueroa, Katherine, Cagnon, Laurence, Lagaud, Guy, Ver Donck, Luc, Ghoos, Etienne, Allison, Brett, Rabinowitz, Michael H, Shankley, Nigel P
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2011)
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Scaffold Hopping with Molecular Field Points: Identification of a Cholecystokinin-2 (CCK2) Receptor Pharmacophore and Its Use in the Design of a Prototypical Series of Pyrrole- and Imidazole-Based CCK2 Antagonists
Low, Caroline M. R, Buck, Ildiko M, Cooke, Tracey, Cushnir, Julia R, Kalindjian, S. Barret, Kotecha, Atul, Pether, Michael J, Shankley, Nigel P, Vinter, J. G, Wright, Laurence
Published in Journal of medicinal chemistry (03.11.2005)
Published in Journal of medicinal chemistry (03.11.2005)
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Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists II: Tuning of receptor selectivity and in vivo efficacy
Pippel, Marna, Boyce, Kristen, Venkatesan, Hariharan, Phuong, Victor K., Yan, Wen, Barrett, Terrance D., Lagaud, Guy, Li, Lina, Morton, Magda F., Prendergast, Clodagh, Wu, Xiaodong, Shankley, Nigel P., Rabinowitz, Michael H.
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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Species‐dependent smooth muscle contraction to Neuromedin U and determination of the receptor subtypes mediating contraction using NMU1 receptor knockout mice
Prendergast, Clodagh E, Morton, Magda F, Figueroa, Katherine W, Wu, Xiaodong, Shankley, Nigel P
Published in British journal of pharmacology (01.04.2006)
Published in British journal of pharmacology (01.04.2006)
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Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: Discovery of CCKR1 selectivity in a previously CCKR2-selective lead series
Pippel, Marna, Allison, Brett D., Phuong, Victor K., Li, Lina, Morton, Magda F., Prendergast, Clodagh, Wu, Xiaodong, Shankley, Nigel P., Rabinowitz, Michael H.
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
Published in Bioorganic & medicinal chemistry letters (15.11.2009)
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Identification and Optimization of Anthranilic Sulfonamides as Novel, Selective Cholecystokinin-2 Receptor Antagonists
Allison, Brett D, Phuong, Victor K, McAtee, Laura C, Rosen, Mark, Morton, Magda, Prendergast, Clodagh, Barrett, Terry, Lagaud, Guy, Freedman, Jamie, Li, Lina, Wu, Xiaodong, Venkatesan, Hariharan, Pippel, Marna, Woods, Craig, Rizzolio, Michèle C, Hack, Michael, Hoey, Kenway, Deng, Xiaohu, King, Christopher, Shankley, Nigel P, Rabinowitz, Michael H
Published in Journal of medicinal chemistry (19.10.2006)
Published in Journal of medicinal chemistry (19.10.2006)
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Characterization of a Robust Enzymatic Assay for Inhibitors of 2-Oxoglutarate-Dependent Hydroxylases
Kanelakis, Kimon C., Palomino, Heather L., Li, Lina, Wu, Jiejun, Yan, Wen, Rosen, Mark D., Rizzolio, Michele C., Trivedi, Meghana, Morton, Magda F., Yang, Young, Venkatesan, Hariharan, Rabinowitz, Michael H., Shankley, Nigel P., Barrett, Terrance D.
Published in Journal of biomolecular screening (01.07.2009)
Published in Journal of biomolecular screening (01.07.2009)
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3-[5-(3,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionate (JNJ-17156516), a Novel, Potent, and Selective Cholecystokinin 1 Receptor Antagonist: In Vitro and in Vivo Pharmacological Comparison with Dexloxiglumide
Morton, Magda F, Barrett, Terrance D, Yan, Wen, Freedman, Jamie M, Lagaud, Guy, Prendergast, Clodagh E, Moreno, Veronica, Pyati, Jayashree, Figueroa, Katherine, Li, Lina, Wu, Xiaodong, Rizzolio, Michele, Breitenbucher, James G, McClure, Kelly, Shankley, Nigel P
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2007)
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Pyrazole CCK1 receptor antagonists. Part 2: SAR studies by solid-phase library synthesis and determination of Free-Wilson additivity
SEHON, Clark, MCCLURE, Kelly, HACK, Michael, MORTON, Magda, GOMEZ, Laurent, LI, Lina, BARRETT, Terrance D, SHANKLEY, Nigel, BREITENBUCHER, J. Guy
Published in Bioorganic & medicinal chemistry letters (2006)
Published in Bioorganic & medicinal chemistry letters (2006)
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Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro
Jones, Neil A., Morton, Magda F., Prendergast, Clodagh E., Powell, Garth L., Shankley, Nigel P., Hollingsworth, Simon J.
Published in Regulatory peptides (11.09.2006)
Published in Regulatory peptides (11.09.2006)
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Design, Synthesis, and Structure−Activity Relationships of Novel Non-Imidazole Histamine H3 Receptor Antagonists
Linney, Ian D, Buck, Ildiko M, Harper, Elaine A, Kalindjian, S. Barret, Pether, Michael J, Shankley, Nigel P, Watt, Gillian F, Wright, Paul T
Published in Journal of medicinal chemistry (15.06.2000)
Published in Journal of medicinal chemistry (15.06.2000)
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Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands
Woods, Craig R., Hack, Michael D., Allison, Brett D., Phuong, Victor K., Rosen, Mark D., Morton, Magda F., Prendergast, Clodagh E., Barrett, Terrance D., Shankley, Nigel P., Rabinowitz, Michael H.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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