Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics
Chen, Zehan, Xiao, Zhan, Gu, Wen‐zhen, Xue, John, Bui, Mai H., Kovar, Peter, Li, Gaoquan, Wang, Gary, Tao, Zhi‐Fu, Tong, Yunsong, Lin, Nan‐Horng, Sham, Hing L., Wang, Jean Y. J., Sowin, Thomas J., Rosenberg, Saul H., Zhang, Haiying
Published in International journal of cancer (15.12.2006)
Published in International journal of cancer (15.12.2006)
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Journal Article
Discovery of Potent, Selective, Orally Bioavailable Stearoyl-CoA Desaturase 1 Inhibitors
Liu, Gang, Lynch, John K, Freeman, Jennifer, Liu, Bo, Xin, Zhili, Zhao, Hongyu, Serby, Michael D, Kym, Philip R, Suhar, Tom S, Smith, Harriet T, Cao, Ning, Yang, Ruojing, Janis, Rich S, Krauser, Joel A, Cepa, Steven P, Beno, David W. A, Sham, Hing L, Collins, Christine A, Surowy, Teresa K, Camp, Heidi S
Published in Journal of medicinal chemistry (28.06.2007)
Published in Journal of medicinal chemistry (28.06.2007)
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Journal Article
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors
Xu, Ying-zi, Yuan, Shendong, Bowers, Simeon, Hom, Roy K., Chan, Wayman, Sham, Hing L., Zhu, Yong L., Beroza, Paul, Pan, Hu, Brecht, Eric, Yao, Nanhua, Lougheed, Julie, Yan, Jiangli, Tam, Danny, Ren, Zhao, Ruslim, Lany, Bova, Michael P., Artis, Dean R.
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
Published in Bioorganic & medicinal chemistry letters (15.05.2013)
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Journal Article
Discovery of piperidine-aryl urea-based stearoyl-CoA desaturase 1 inhibitors
Xin, Zhili, Zhao, Hongyu, Serby, Michael D., Liu, Bo, Liu, Mei, Szczepankiewicz, Bruce G., Nelson, Lissa T.J., Smith, Harriet T., Suhar, Tom S., Janis, Rich S., Cao, Ning, Camp, Heidi S., Collins, Christine A., Sham, Hing L., Surowy, Teresa K., Liu, Gang
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors
Bowers, Simeon, Truong, Anh P., Ye, Michael, Aubele, Danielle L., Sealy, Jennifer M., Neitz, R. Jeffrey, Hom, Roy K., Chan, Wayman, Dappen, Michael S., Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Zhu, Yong L., Beroza, Paul, Tonn, George, Zhang, Heather, Hoffman, Jennifer, Motter, Ruth, Fauss, Donald, Tanaka, Pearl, Bova, Michael P., Ren, Zhao, Tam, Danny, Ruslim, Lany, Baker, Jeanne, Pandya, Deepal, Diep, Linnea, Fitzgerald, Kent, Artis, Dean R., Anderson, John P., Bergeron, Marcelle
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
Published in Bioorganic & medicinal chemistry letters (01.05.2013)
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Journal Article
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model
Truong, Anh P., Tóth, Gergley, Probst, Gary D., Sealy, Jennifer M., Bowers, Simeon, Wone, David W.G., Dressen, Darren, Hom, Roy K., Konradi, Andrei W., Sham, Hing L., Wu, Jing, Peterson, Brian T., Ruslim, Lany, Bova, Michael P., Kholodenko, Dora, Motter, Ruth N., Bard, Frédérique, Santiago, Pamela, Ni, Huifang, Chian, David, Soriano, Ferdie, Cole, Tracy, Brigham, Elizabeth F., Wong, Karina, Zmolek, Wes, Goldbach, Erich, Samant, Bhushan, Chen, Linda, Zhang, Hongbing, Nakamura, David F., Quinn, Kevin P., Yednock, Ted A., Sauer, John-Michael
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
Published in Bioorganic & medicinal chemistry letters (01.11.2010)
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Journal Article
Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor
Bowers, Simeon, Truong, Anh P., Neitz, R. Jeffrey, Neitzel, Martin, Probst, Gary D., Hom, Roy K., Peterson, Brian, Galemmo, Robert A., Konradi, Andrei W., Sham, Hing L., Tóth, Gergley, Pan, Hu, Yao, Nanhua, Artis, Dean R., Brigham, Elizabeth F., Quinn, Kevin P., Sauer, John-Michael, Powell, Kyle, Ruslim, Lany, Ren, Zhao, Bard, Frédérique, Yednock, Ted A., Griswold-Prenner, Irene
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Discovery of Potent, Highly Selective, and Orally Bioavailable Pyridine Carboxamide c-Jun NH2-Terminal Kinase Inhibitors
Zhao, Hongyu, Serby, Michael D, Xin, Zhili, Szczepankiewicz, Bruce G, Liu, Mei, Kosogof, Christi, Liu, Bo, Nelson, Lissa T. J, Johnson, Eric F, Wang, Sanyi, Pederson, Terry, Gum, Rebecca J, Clampit, Jill E, Haasch, Deanna L, Abad-Zapatero, Cele, Fry, Elizabeth H, Rondinone, Cristina, Trevillyan, James M, Sham, Hing L, Liu, Gang
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
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Journal Article
Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 Inhibitors
Gu, Yu Gui, Weitzberg, Moshe, Clark, Richard F, Xu, Xiangdong, Li, Qun, Zhang, Tianyuan, Hansen, T. Matthew, Liu, Gang, Xin, Zhili, Wang, Xiaojun, Wang, Rongqi, McNally, Teresa, Camp, Heidi, Beutel, Bruce A, Sham, Hing L
Published in Journal of medicinal chemistry (29.06.2006)
Published in Journal of medicinal chemistry (29.06.2006)
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Journal Article
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies
Liu, Mei, Wang, Sanyi, Clampit, Jill E., Gum, Rebecca J., Haasch, Deanna L., Rondinone, Cristina M., Trevillyan, James M., Abad-Zapatero, Cele, Fry, Elizabeth H., Sham, Hing L., Liu, Gang
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Journal Article
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
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Journal Article
Design, Synthesis, and Biological Activity of 5,10-Dihydro-dibenzo[b,e][1,4]diazepin-11-one-Based Potent and Selective Chk-1 Inhibitors
Wang, Le, Sullivan, Gerard M, Hexamer, Laura A, Hasvold, Lisa A, Thalji, Reema, Przytulinska, Magdalena, Tao, Zhi-Fu, Li, Gaoquan, Chen, Zehan, Xiao, Zhan, Gu, Wen-Zhen, Xue, John, Bui, Mai-Ha, Merta, Philip, Kovar, Peter, Bouska, Jennifer J, Zhang, Haiying, Park, Chang, Stewart, Kent D, Sham, Hing L, Sowin, Thomas J, Rosenberg, Saul H, Lin, Nan-Horng
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Journal Article
Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents
Clark, Richard F., Zhang, Tianyuan, Wang, Xiaojun, Wang, Rongqi, Zhang, Xiaolin, Camp, Heidi S., Beutel, Bruce A., Sham, Hing L., Gu, Yu Gui
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
Published in Bioorganic & medicinal chemistry letters (01.04.2007)
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Journal Article
Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Madar, David J, Longenecker, Kenton, Yong, Hong, Lubben, Thomas H, Stewart, Kent D, Zinker, Bradley A, Backes, Bradley J, Judd, Andrew S, Mulhern, Mathew, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Reinhart, Glenn A, Fryer, Ryan M, Preusser, Lee C, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth
Chen, Zehan, Merta, Philip J, Lin, Nan-Hong, Tahir, Stephen K, Kovar, Peter, Sham, Hing L, Zhang, Haiying
Published in Molecular cancer therapeutics (01.04.2005)
Published in Molecular cancer therapeutics (01.04.2005)
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Journal Article
Discovery of 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-benzonitriles and 4′-(1,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-pyridine-2′-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors
Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Stewart, Kent D., Chen, Zehan, Bui, Mai-Ha, Merta, Philip, Park, Chang, Kovar, Peter, Zhang, Haiying, Sham, Hing L., Rosenberg, Saul H., Sowin, Thomas J., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Journal Article
Synthesis and Biological Evaluation of 2-Indolyloxazolines as a New Class of Tubulin Polymerization Inhibitors. Discovery of A-289099 as an Orally Active Antitumor Agent
Li, Qun, Woods, Keith W., Claiborne, Akiyo, Gwaltney, II, Stephen L., Barr, Kenneth J., Liu, Gang, Gehrke, Laura, Credo, R.Bruce, Hui, Yu Hua, Lee, Jang, Warner, Robert B., Kovar, Peter, Nukkala, Michael A., Zielinski, Nicolette A., Tahir, Stephen K., Fitzgerald, Michael, Kim, Ki H., Marsh, Kennan, Frost, David, Ng, Shi-Chung, Rosenberg, Saul, Sham, Hing L.
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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Journal Article
X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease
STOLL, Vincent, WENYING QIN, KEMPF, Dale, SHAM, Hing L, NORBECK, Daniel W, STEWART, Kent D, JAKOB, Clarissa, CHANG PARK, WALTER, K, SIMMER, R. L, HELFRICH, Rosalind, BUSSIERE, Dirk, KAO, J
Published in Bioorganic & medicinal chemistry (01.08.2002)
Published in Bioorganic & medicinal chemistry (01.08.2002)
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Journal Article
Synthesis and biological evaluation of 4′-(6,7-disubstituted-2,4-dihydro-indeno[1,2- c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors
Tao, Zhi-Fu, Li, Gaoquan, Tong, Yunsong, Chen, Zehan, Merta, Philip, Kovar, Peter, Zhang, Haiying, Rosenberg, Saul H., Sham, Hing L., Sowin, Thomas J., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
Published in Bioorganic & medicinal chemistry letters (01.08.2007)
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Journal Article
Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors
Li, Gaoquan, Hasvold, Lisa A., Tao, Zhi-Fu, Wang, Gary T., Gwaltney, Stephen L., Patel, Jyoti, Kovar, Peter, Credo, Robert B., Chen, Zehan, Zhang, Haiying, Park, Chang, Sham, Hing L., Sowin, Thomas, Rosenberg, Saul H., Lin, Nan-Horng
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
Published in Bioorganic & medicinal chemistry letters (15.04.2006)
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