Potent GCN2 Inhibitor Capable of Reversing MDSC-Driven T Cell Suppression Demonstrates In Vivo Efficacy as a Single Agent and in Combination with Anti-Angiogenesis Therapy
Jackson, Jeffrey J., Shibuya, Grant M., Ravishankar, Buvana, Adusumilli, Lavanya, Bradford, Delia, Brockstedt, Dirk G., Bucher, Cyril, Bui, Minna, Cho, Cynthia, Colas, Christoph, Cutler, Gene, Dukes, Adrian, Han, Xinping, Hu, Dennis X., Jacobson, Scott, Kassner, Paul D., Katibah, George E., Ko, Michelle Yoo Min, Kolhatkar, Urvi, Leger, Paul R., Ma, Anqi, Marshall, Lisa, Maung, Jack, Ng, Andrew A., Okano, Akinori, Pookot, Deepa, Poon, Daniel, Ramana, Chandru, Reilly, Maureen K., Robles, Omar, Schwarz, Jacob B., Shakhmin, Anton A., Shunatona, Hunter P., Sreenivasan, Raashi, Tivitmahaisoon, Parcharee, Xu, Mengshu, Zaw, Thant, Wustrow, David J., Zibinsky, Mikhail
Published in Journal of medicinal chemistry (13.10.2022)
Published in Journal of medicinal chemistry (13.10.2022)
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Journal Article
Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc
Shakhmin, Anton, Hall, Mary P., Machleidt, Thomas, Walker, Joel R., Wood, Keith V., Kirkland, Thomas A.
Published in Organic & biomolecular chemistry (28.10.2017)
Published in Organic & biomolecular chemistry (28.10.2017)
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Journal Article
Coelenterazine analogues emit red-shifted bioluminescence with NanoLucElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ob01985h
Shakhmin, Anton, Hall, Mary P, Machleidt, Thomas, Walker, Joel R, Wood, Keith V, Kirkland, Thomas A
Year of Publication 18.10.2017
Year of Publication 18.10.2017
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Journal Article
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety
Cohen, Frederick, Aggen, James B., Andrews, Logan D., Assar, Zahra, Boggs, Jen, Choi, Taylor, Dozzo, Paola, Easterday, Ashton N., Haglund, Cat M., Hildebrandt, Darin J., Holt, Melissa C., Joly, Kristin, Jubb, Adrian, Kamal, Zeeshan, Kane, Timothy R., Konradi, Andrei W., Krause, Kevin M., Linsell, Martin S., Machajewski, Timothy D., Miroshnikova, Olga, Moser, Heinz E., Nieto, Vincent, Phan, Thu, Plato, Craig, Serio, Alisa W., Seroogy, Julie, Shakhmin, Anton, Stein, Adam J., Sun, Alex D., Sviridov, Serguei, Wang, Zhan, Wlasichuk, Kenneth, Yang, Wen, Zhou, Xiaoming, Zhu, Hai, Cirz, Ryan T.
Published in ChemMedChem (20.08.2019)
Published in ChemMedChem (20.08.2019)
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Journal Article
Coelenterazine analogues emit red-shifted bioluminescence with NanoLuc
Shakhmin, Anton, Hall, Mary P, Machleidt, Thomas, Walker, Joel R, Wood, Keith V, Kirkland, Thomas A
Published in Organic & biomolecular chemistry (18.10.2017)
Published in Organic & biomolecular chemistry (18.10.2017)
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Journal Article
BF3−H2O Catalyzed Hydroxyalkylation of Aromatics with Aromatic Aldehydes and Dicarboxaldehydes: Efficient Synthesis of Triarylmethanes, Diarylmethylbenzaldehydes, and Anthracene Derivatives
Prakash, G. K. Surya, Panja, Chiradeep, Shakhmin, Anton, Shah, Eric, Mathew, Thomas, Olah, George A
Published in Journal of organic chemistry (20.11.2009)
Published in Journal of organic chemistry (20.11.2009)
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Journal Article
Abstract 3153: Targeting the stress response kinase GCN2 to restore immunity in the tumor microenvironment
Marshall, Lisa, Ravishankar, Buvana, Kolhatkar, Urvi, Xu, Mengshu, Adusumilli, Lavanya, Pookot, Deepa, Zaw, Thant, Ramana, Chandru, Sreenivasan, Raashi, Zibinsky, Mikhail, Jackson, Jeffrey, Shibuya, Grant, Leger, Paul, Robles, Omar, Ma, Anqi, Ng, Andrew, Shakhmin, Anton, Guagua, Justy, Jacobson, Scott, Wong, Steve, Bradford, Delia, McGaha, Tracy L., Ciudad, M Teresa, Talmadge, James E., Britton, Holly C., Katibah, George, Cutler, Gene, Wustrow, David, Kassner, Paul D., Brockstedt, Dirk G.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Abstract 1646: Development of small-molecule HPK1 inhibitors to unleash tumor-specific T cell responses
Katibah, George, Ohol, Yamini, Bucher, Cyril, Adusumilli, Lavanya, Kaveri, Deepika, Robles, Omar, Sun, Michael, Cho, Cynthia, Milestone, Heather, Ames, Rachel, Jacobson, Scott, Nebalasca, Dan, Gomez- Guagua, Justy, Sanchez, Jerick, Grandcolas, Molly, Wong, Steve, Brovarney, Martin, Ramana, Chandru, Zaw, Thant, Nguyen, Lan, Tivitmahaisoon, Parcharee, Ng, Andrew, Ma, Anqi, Gomez, Blanca, Ko, Michelle, Leger, Paul, Jackson, Jeffrey, Shibuya, Grant, Shakhmin, Anton, Bradford, Delia, Xu, Mengshu, Zibinsky, Mikhail, Poon, Daniel, Wustrow, David, Kassner, Paul, Brockstedt, Dirk
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Three Efficient Methods for Preparation of Coelenterazine Analogues
Shakhmin, Anton, Hall, Mary P., Walker, Joel R., Machleidt, Thomas, Binkowski, Brock F., Wood, Keith V., Kirkland, Thomas A.
Published in Chemistry : a European journal (18.07.2016)
Published in Chemistry : a European journal (18.07.2016)
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Journal Article
Poly(N-vinylpyrrolidone)-H2O2 and poly(4-vinylpyridine)-H2O2 complexes: solid H2O2 equivalents for selective oxidation of sulfides to sulfoxides and ketones to gem-dihydroperoxides
Prakash, G. K. Surya, Shakhmin, Anton, Glinton, Kevin E., Rao, Sneha, Mathew, Thomas, Olah, George A.
Published in Green chemistry : an international journal and green chemistry resource : GC (01.01.2014)
Published in Green chemistry : an international journal and green chemistry resource : GC (01.01.2014)
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Journal Article
Poly(N-vinylpyrrolidone)-H2O2 and poly(4-vinylpyridine)-H2O2 complexes: solid H2O2 equivalents for selective oxidation of sulfides to sulfoxides and ketones to gem-dihydroperoxidesElectronic supplementary information (ESI) available: Characterization (NMR) data and copies of 1H and 13C spectra of the products. See DOI: 10.1039/c4gc00586d
Surya Prakash, G. K, Shakhmin, Anton, Glinton, Kevin E, Rao, Sneha, Mathew, Thomas, Olah, George A
Year of Publication 24.06.2014
Year of Publication 24.06.2014
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Journal Article
Abstract 2654: HPK1 inhibits CD8+ T cell effector gene expression following T cell activation
Ames, Rachel Y., Zhao, Rongqi, Mace, Parker, Grant, Adam, Xie, Guorui, Milestone, Heather, Grandcolas, Molly, Fang, Eva, Kiosea, Nicolae, Wong, Stephen, Brovarney, Martin, Jacobson, Scott, Nebalasca, Danilo, Arguello, Jorge, Gomez, Blanca, Kandala, Hiranmayee, Ko, Michelle Y., Nguyen, Lan, Robles, Omar, Shibuya, Grant, Shakhmin, Anton A., Tivitmahaisoon, Parcharee, Vu, Vi-Anh, Younai, Ashkaan, Zibinsky, Mikhail, Subramanyam, Babu, Poon, Daniel, Ghomi, Mohsen Sabouri, Wustrow, David J., Kassner, Paul D., Katibah, George E., Brockstedt, Dirk G.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Poly(N-vinylpyrrolidone)-H sub(2)O sub(2) and poly(4-vinylpyridine)-H sub(2)O sub(2 ) complexes: solid H sub(2)O sub(2) equivalents for selective oxidation of sulfides to sulfoxides and ketones to gem-dihydroperoxides
Surya Prakash, GK, Shakhmin, Anton, Glinton, Kevin E, Rao, Sneha, Mathew, Thomas, Olah, George A
Published in Green chemistry : an international journal and green chemistry resource : GC (01.06.2014)
Published in Green chemistry : an international journal and green chemistry resource : GC (01.06.2014)
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Journal Article
Synthesis of monofluoroalkenes via Julia–Kocienski reaction
Prakash, G.K. Surya, Shakhmin, Anton, Zibinsky, Mikhail, Ledneczki, Istvan, Chacko, Sujith, Olah, George A.
Published in Journal of fluorine chemistry (01.11.2010)
Published in Journal of fluorine chemistry (01.11.2010)
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Journal Article
Preparation of fluorinated RNA nucleotide analogs potentially stable to enzymatic hydrolysis in RNA and DNA polymerase assays
Shakhmin, Anton, Jones, John-Paul, Bychinskaya, Inessa, Zibinsky, Mikhail, Oertell, Keriann, Goodman, Myron F., Prakash, G.K. Surya
Published in Journal of fluorine chemistry (01.11.2014)
Published in Journal of fluorine chemistry (01.11.2014)
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Journal Article
BF 3 −H 2 O Catalyzed Hydroxyalkylation of Aromatics with Aromatic Aldehydes and Dicarboxaldehydes: Efficient Synthesis of Triarylmethanes, Diarylmethylbenzaldehydes, and Anthracene Derivatives
Prakash, G. K. Surya, Panja, Chiradeep, Shakhmin, Anton, Shah, Eric, Mathew, Thomas, Olah, George A.
Published in Journal of organic chemistry (20.11.2009)
Published in Journal of organic chemistry (20.11.2009)
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Journal Article
CELL IMPERMEABLE COELENTERAZINE ANALOGUES
MEISENHEIMER, Poncho, HALL, Mary, WALKER, Joel, R, KIRKLAND, Thomas, SHAKHMIN, Anton, ZHOU, Wenhui, OHANA, Rachel, Friedman
Year of Publication 05.08.2024
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Year of Publication 05.08.2024
Patent
COELENTERAZINE ANALOGUES TETHERED TO ENERGY ACCEPTORS
MACHLEIDT, Thomas, HALL, Mary, KIRKLAND, Thomas, WOOD, Keith V, SHAKHMIN, Anton, ZHOU, Wenhui, WALKER, Joel R
Year of Publication 29.05.2024
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Year of Publication 29.05.2024
Patent