Synthesis and evaluation of N-[(1 S,2 S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists
Du, Wu, Jewell, James P., Lin, Linus S., Colandrea, Vincent J., Xiao, Jing C., Lao, Julie, Shen, Chun-Pyn, Bateman, Thomas J., Reddy, Vijay B.G., Ha, Sookhee N., Shah, Shrenik K., Fong, Tung M., Hale, Jeffrey J., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists
He, Shuwen, Dobbelaar, Peter H., Guo, Liangqin, Ye, Zhixiong, Liu, Jian, Jian, Tianying, Truong, Quang, Shah, Shrenik K., Du, Wu, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James D., Sherer, Edward, Pasternak, Alexander, Feng, Zhe, Reibarkh, Mikhail, Lin, Melissa, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J., Li, Cai, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
Published in Bioorganic & medicinal chemistry letters (15.03.2016)
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Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), in Rodents
Fong, Tung M., Guan, Xiao-Ming, Marsh, Donald J., Shen, Chun-Pyn, Stribling, D. Sloan, Rosko, Kim M., Lao, Julie, Yu, Hong, Feng, Yue, Xiao, Jing C., Van der Ploeg, Lex H. T., Goulet, Mark T., Hagmann, Williams K., Lin, Linus S., Lanza, Thomas J., Jewell, James P., Liu, Ping, Shah, Shrenik K., Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S., Francis, Barbara, Strack, Alison M., MacIntyre, D. Euan, Shearman, Lauren P.
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2007)
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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes
Shah, Shrenik K, He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V, Reddy, Vijay B, Mitelman, Stan, Tong, Sharon X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E, Eiermann, George J, Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B, Howard, Andrew D, Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P, Hagmann, William K
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a Novel, Acyclic Cannabinoid-1 Receptor Inverse Agonist for the Treatment of Obesity
Lin, Linus S, Lanza, Thomas J, Jewell, James P, Liu, Ping, Shah, Shrenik K, Qi, Hongbo, Tong, Xinchun, Wang, Junying, Xu, Suoyu S, Fong, Tung M, Shen, Chun-Pyn, Lao, Julie, Xiao, Jing Chen, Shearman, Lauren P, Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Marsh, Donald J, Feng, Yue, Kumar, Sanjeev, Samuel, Koppara, Yin, Wenji, Van der Ploeg, Lex H. T, Goulet, Mark T, Hagmann, William K
Published in Journal of medicinal chemistry (28.12.2006)
Published in Journal of medicinal chemistry (28.12.2006)
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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists
He, Shuwen, Lai, Zhong, Ye, Zhixiong, Dobbelaar, Peter H, Shah, Shrenik K, Truong, Quang, Du, Wu, Guo, Liangqin, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K, Hong, Qingmei, Dellureficio, James, Reibarkh, Mikhail, Samuel, Koppara, Reddy, Vijay B, Mitelman, Stan, Tong, Sharon X, Chicchi, Gary G, Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J, Li, Cai, Zhang, Bei, Howard, Andrew D, Zhou, Yun-Ping, Nargund, Ravi P, Hagmann, William K
Published in ACS medicinal chemistry letters (10.07.2014)
Published in ACS medicinal chemistry letters (10.07.2014)
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Orally active .beta.-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones
Shah, Shrenik K, Dorn, Conrad P, Finke, Paul E, Hale, Jeffrey J, Hagmann, William K, Brause, Karen A, Chandler, Gilbert O, Kissinger, Amy L, Ashe, Bonnie M
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents
SHEARMAN, Lauren P, SLOAN STRIBLING, D, SPANN, Stephanie K, MACNEIL, Douglas J, FONG, Tung M, METZGER, Joseph M, GOULET, Mark T, HAGMANN, William K, PLUMMER, Christopher W, FINKE, Paul E, MILLS, Sander G, SHAH, Shrenik K, CAMACHO, Ramon E, TRUONG, Quang, VAN DER PLOEG, L. H. T, EUAN MACINTYRE, D, STRACK, Alison M, ROSKO, Kimberly M, JUNYING WANG, TONG, Sharon, YUE FENG, MARSH, Donald J, HONG YU, XIAOMING GUAN
Published in European journal of pharmacology (28.01.2008)
Published in European journal of pharmacology (28.01.2008)
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Journal Article
Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists
Armstrong, Helen E., Galka, Amy, Lin, Linus S., Lanza, Thomas J., Jewell, James P., Shah, Shrenik K., Guthikonda, Ravi, Truong, Quang, Chang, Linda L., Quaker, Grace, Colandrea, Vincent J., Tong, Xinchun, Wang, Junying, Xu, Sherry, Fong, Tung M., Shen, Chun-Pyn, Lao, Julie, Chen, Jing, Shearman, Lauren P., Stribling, D. Sloan, Rosko, Kimberly, Strack, Alison, Ha, Sookhee, der Ploeg, Lex Van, Goulet, Mark T., Hagmann, William K.
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Journal Article
Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
Shankaran, K, Donnelly, Karla L, Shah, Shrenik K, Guthikonda, Ravindra N, MacCoss, Malcolm, Humes, John L, Pacholok, Stephen G, Grant, Stephan K, Kelly, T.M, Wong, K.K
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
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Journal Article
Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase
Guthikonda, Ravindra N., Shah, Shrenik K., Pacholok, Stephen G., Humes, John L., Mumford, Richard A., Grant, Stephan K., Chabin, Renee M., Green, Barbara G., Tsou, Nancy, Ball, Richard, Fletcher, Daniel S., Luell, Silvi, Euan MacIntyre, D., MacCoss, Malcolm
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
Published in Bioorganic & medicinal chemistry letters (15.04.2005)
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Journal Article
Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases
Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Caldwell, Charles G., Chen, Ping, Hagmann, William K., MacCoss, Malcolm, Humes, John L., Pacholok, Stephen G., Kelly, Theresa M., Grant, Stephan K., Wong, Kenny K.
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
Published in Bioorganic & medicinal chemistry letters (06.12.2004)
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Journal Article
Synthesis and evaluation of CCR5 antagonists containing modified 4-piperidinyl-2-phenyl-1-(phenylsulfonylamino)-butane
Shah, Shrenik K., Chen, Natalie, Guthikonda, Ravindra N., Mills, Sander G., Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A., Carella, Anthony, Carver, Gwen, Holmes, Karen, Schleif, William A., Danzeisen, Renee, Hazuda, Daria, Kessler, Joseph, Lineberger, Janet, Miller, Michael, Emini, Emilio A., MacCoss, Malcolm
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
Published in Bioorganic & medicinal chemistry letters (15.02.2005)
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Journal Article
Orally active .beta.-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution
Hagmann, William K, Kissinger, Amy L, Shah, Shrenik K, Finke, Paul E, Dorn, Conrad P, Brause, Karen A, Ashe, Bonnie M, Weston, Hazel, Maycock, Alan L
Published in Journal of medicinal chemistry (01.03.1993)
Published in Journal of medicinal chemistry (01.03.1993)
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Journal Article
Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor
Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Guthikonda, Ravindra N., MacCoss, Malcolm, Mills, Sander G., Gould, Sandra L., Malkowitz, Lorraine, Siciliano, Salvatore J., Springer, Martin S., Carella, Anthony, Carver, Gwen, Hazuda, Daria, Holmes, Karen, Kessler, Joseph, Lineberger, Janet, Miller, Michael D., Emini, Emilio A., Schleif, William A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 3: A proposed pharmacophore model for 1-[ N-(methyl)- N-(phenylsulfonyl)amino]-2-(phenyl)-4-[4-(substituted)piperidin-1-yl]butanes
Finke, Paul E., Meurer, Laura C., Oates, Bryan, Shah, Shrenik K., Loebach, Jennifer L., Mills, Sander G., MacCoss, Malcolm, Castonguay, Laurie, Malkowitz, Lorraine, Springer, Martin S., Gould, Sandra L., DeMartino, Julie A.
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
Published in Bioorganic & medicinal chemistry letters (17.09.2001)
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Journal Article
Selenium stabilized carbanions. Preparation of .alpha.-lithio selenides and applications to the synthesis of olefins by reductive elimination of .beta.-hydroxy selenides and selenoxide syn elimination
Reich, Hans J, Chow, Flora, Shah, Shrenik K
Published in Journal of the American Chemical Society (01.10.1979)
Published in Journal of the American Chemical Society (01.10.1979)
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Structural Requirements for Human Inducible Nitric Oxide Synthase Substrates and Substrate Analogue Inhibitors
Grant, Stephan K, Green, Barbara G, Stiffey-Wilusz, Janet, Durette, Philippe L, Shah, Shrenik K, Kozarich, John W
Published in Biochemistry (Easton) (24.03.1998)
Published in Biochemistry (Easton) (24.03.1998)
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Journal Article
Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists
Shankaran, K., Donnelly, Karla L., Shah, Shrenik K., Caldwell, Charles G., Chen, Ping, Finke, Paul E., Oates, Bryan, MacCoss, Malcolm, Mills, Sander G., DeMartino, Julie A., Gould, Sandra L., Malkowitz, Lorraine, Siciliano, Salvatore J., Springer, Martin S., Kwei, Gloria, Carella, Anthony, Carver, Gwen, Danzeisen, Renee, Hazuda, Daria, Holmes, Karen, Kessler, Joseph, Lineberger, Janet, Miller, Michael D., Emini, Emilio A., Schleif, William A.
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
Published in Bioorganic & medicinal chemistry letters (05.07.2004)
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