Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation
Popovic, Relja, Martinez-Garcia, Eva, Giannopoulou, Eugenia G, Zhang, Quanwei, Zhang, Qingyang, Ezponda, Teresa, Shah, Mrinal Y, Zheng, Yupeng, Will, Christine M, Small, Eliza C, Hua, Youjia, Bulic, Marinka, Jiang, Yanwen, Carrara, Matteo, Calogero, Raffaele A, Kath, William L, Kelleher, Neil L, Wang, Ji-Ping, Elemento, Olivier, Licht, Jonathan D
Published in PLoS genetics (01.09.2014)
Published in PLoS genetics (01.09.2014)
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UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition
Ezponda, Teresa, Dupéré-Richer, Daphné, Will, Christine M., Small, Eliza C., Varghese, Nobish, Patel, Tej, Nabet, Behnam, Popovic, Relja, Oyer, Jon, Bulic, Marinka, Zheng, Yupeng, Huang, Xiaoxiao, Shah, Mrinal Y., Maji, Sayantan, Riva, Alberto, Occhionorelli, Manuela, Tonon, Giovanni, Kelleher, Neil, Keats, Jonathan, Licht, Jonathan D.
Published in Cell reports (Cambridge) (17.10.2017)
Published in Cell reports (Cambridge) (17.10.2017)
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Journal Article
DNMT3B7, a Truncated DNMT3B Isoform Expressed in Human Tumors, Disrupts Embryonic Development and Accelerates Lymphomagenesis
SHAH, Mrinal Y, VASANTHAKUMAR, Aparna, LE BEAU, Michelle M, MOSKOWITZ, Ivan P, MELNICK, Ari, PYTEL, Peter, GODLY, Lucy A, BARNES, Natalie Y, FIGUEROA, Maria E, KAMP, Anna, HENDRICK, Christopher, OSTLER, Kelly R, DAVIS, Elizabeth M, SHANG LIN, ANASTASI, John
Published in Cancer research (Chicago, Ill.) (15.07.2010)
Published in Cancer research (Chicago, Ill.) (15.07.2010)
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Journal Article
CRISPR-Cas9 In Vivo Gene Editing of KLKB1 for Hereditary Angioedema
Longhurst, Hilary J., Lindsay, Karen, Petersen, Remy S., Fijen, Lauré M., Gurugama, Padmalal, Maag, David, Butler, James S., Shah, Mrinal Y., Golden, Adele, Xu, Yuanxin, Boiselle, Carri, Vogel, Joseph D., Abdelhady, Ahmed M., Maitland, Michael L., McKee, Mark D., Seitzer, Jessica, Han, Bo W., Soukamneuth, Samantha, Leonard, John, Sepp-Lorenzino, Laura, Clark, Eliana D., Lebwohl, David, Cohn, Danny M.
Published in The New England journal of medicine (01.02.2024)
Published in The New England journal of medicine (01.02.2024)
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CRISPR-Based Therapy for Hereditary Angioedema
Cohn, Danny M, Gurugama, Padmalal, Magerl, Markus, Katelaris, Constance H, Launay, David, Bouillet, Laurence, Petersen, Remy S, Lindsay, Karen, Aygören-Pürsün, Emel, Maag, David, Butler, James S, Shah, Mrinal Y, Golden, Adele, Xu, Yuanxin, Abdelhady, Ahmed M, Lebwohl, David, Longhurst, Hilary J
Published in The New England journal of medicine (24.10.2024)
Published in The New England journal of medicine (24.10.2024)
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Journal Article
Epigenetic therapy of hematological malignancies: where are we now?
Popovic, Relja, Shah, Mrinal Y., Licht, Jonathan D.
Published in Therapeutic Advances in Hematology (01.04.2013)
Published in Therapeutic Advances in Hematology (01.04.2013)
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Book Review
Journal Article
MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents
Shah, M Y, Martinez-Garcia, E, Phillip, J M, Chambliss, A B, Popovic, R, Ezponda, T, Small, E C, Will, C, Phillip, M P, Neri, P, Bahlis, N J, Wirtz, D, Licht, J D
Published in Oncogene (10.11.2016)
Published in Oncogene (10.11.2016)
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Journal Article
The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer
Ezponda, T, Popovic, R, Shah, M Y, Martinez-Garcia, E, Zheng, Y, Min, D-J, Will, C, Neri, A, Kelleher, N L, Yu, J, Licht, J D
Published in Oncogene (06.06.2013)
Published in Oncogene (06.06.2013)
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Journal Article
DNMT3A mutations in acute myeloid leukemia: new studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A . Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established
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Journal Article
MMSET/WHSC1 Enhances DNA Damage Repair Leading To An Increase In Resistance To Chemotherapeutic Agents
Shah, Mrinal Y., Martinez, Eva, Popovic, Relja, Ezponda, Teresa, Small, Eliza C., Will, Christine, Neri, Paola, Bahlis, Nizar J., Licht, Jonathan D.
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
Abstract 1046: The histone methyl transferase MMSET/WHSC1 promotes an epithelial-mesenchymal transition and invasive properties of prostate cancer
Ezponda-Itoiz, Teresa, Popovic, Relja, Shah, Mrinal Y., Martinez-Garcia, Eva, Min, Dong-Joon, Will, Christine, Licht, Jonathan D.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
MMSET Dysregulates Gene Expression in Myeloma Through Global and Focal Changes in H3K36 and H3K27 Methylation
Popovic, Relja, Martinez, Eva, Zhang, Quanwei, Ezponda, Teresa, Jiang, Yanwen, Shah, Mrinal Y., Will, Christine, Small, Eliza C., Elemento, Olivier, Wang, Ji-Ping, Licht, Jonathan D.
Published in Blood (16.11.2012)
Published in Blood (16.11.2012)
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Journal Article
Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation: e1004566
Popovic, Relja, Martinez-Garcia, Eva, Giannopoulou, Eugenia G, Zhang, Quanwei, Zhang, Qingyang, Ezponda, Teresa, Shah, Mrinal Y, Zheng, Yupeng, Will, Christine M, Small, Eliza C, Hua, Youjia, Bulic, Marinka, Jiang, Yanwen, Carrara, Matteo, Calogero, Raffaele A, Kath, William L, Kelleher, Neil L, Wang, Ji-Ping, Elemento, Olivier, Licht, Jonathan D
Published in PLoS genetics (01.09.2014)
Published in PLoS genetics (01.09.2014)
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Journal Article
MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation
Popovic, Relja, Martinez-Garcia, Eva, Zhang, Quanwei, Ezponda, Teresa, Shah, Mrinal Y, Zhang, Yupeng, Jiang, Yanwen, Will, Christine M, Small, Eliza C, Bulic, Marinka, Elemento, Olivier, Kelleher, Neil, Kath, William, Wang, Ji-Ping, Licht, Jonathan D
Published in Epigenetics & chromatin (18.03.2013)
Published in Epigenetics & chromatin (18.03.2013)
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