Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9
Maekawa, Keiko, Adachi, Motoyasu, Matsuzawa, Yumiko, Zhang, Qinghai, Kuroki, Ryota, Saito, Yoshiro, Shah, Manish B
Published in Biochemistry (Easton) (17.10.2017)
Published in Biochemistry (Easton) (17.10.2017)
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Journal Article
Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison
Parikh, Sonia J, Kamat, Sumit, Phillips, Margaret, Boyson, Samuel P, Yarbrough, Thomas, Davie, Dylan, Zhang, Qinghai, Glass, Karen C, Shah, Manish B
Published in International journal of molecular sciences (22.09.2021)
Published in International journal of molecular sciences (22.09.2021)
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Journal Article
Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules
Shah, Manish B, Wilderman, P. Ross, Pascual, Jaime, Zhang, Qinghai, Stout, C. David, Halpert, James R
Published in Biochemistry (Easton) (18.09.2012)
Published in Biochemistry (Easton) (18.09.2012)
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Journal Article
Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog
Shah, Manish B, Zhang, Qinghai, Halpert, James R
Published in International journal of molecular sciences (29.03.2018)
Published in International journal of molecular sciences (29.03.2018)
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Journal Article
Structure-Function Analysis of Mammalian CYP2B Enzymes Using 7-Substituted Coumarin Derivatives as Probes: Utility of Crystal Structures and Molecular Modeling in Understanding Xenobiotic Metabolism
Shah, Manish B, Liu, Jingbao, Huo, Lu, Zhang, Qinghai, Dearing, M Denise, Wilderman, P Ross, Szklarz, Grazyna D, Stout, C David, Halpert, James R
Published in Molecular pharmacology (01.04.2016)
Published in Molecular pharmacology (01.04.2016)
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Journal Article
Structural and biophysical analysis of cytochrome P450 2C914 and 27 variants in complex with losartan
Parikh, Sonia J., Edara, Sreeja, Deodhar, Shruti, Singh, Ajit K., Maekawa, Keiko, Zhang, Qinghai, Glass, Karen C., Shah, Manish B.
Published in Journal of inorganic biochemistry (01.09.2024)
Published in Journal of inorganic biochemistry (01.09.2024)
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Journal Article
Four Decades of Cytochrome P450 2B Research: From Protein Adducts to Protein Structures and Beyond
Roberts, Arthur G, Stevens, Jeffrey C, Szklarz, Grazyna D, Scott, Emily E, Kumar, Santosh, Shah, Manish B, Halpert, James R
Published in Drug metabolism and disposition (01.01.2023)
Published in Drug metabolism and disposition (01.01.2023)
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Journal Article
Structure of Cytochrome P450 2C92 in Complex with Losartan: Insights into the Effect of Genetic Polymorphism
Parikh, Sonia J., Evans, Chiara M., Obi, Juliet O., Zhang, Qinghai, Maekawa, Keiko, Glass, Karen C., Shah, Manish B.
Published in Molecular pharmacology (01.11.2020)
Published in Molecular pharmacology (01.11.2020)
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Journal Article
Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7‑Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations
Liu, Jingbao, Shah, Manish B, Zhang, Qinghai, Stout, C. David, Halpert, James R, Wilderman, P. Ross
Published in Biochemistry (Easton) (05.04.2016)
Published in Biochemistry (Easton) (05.04.2016)
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Journal Article
Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains
Shah, Manish B, Pascual, Jaime, Zhang, Qinghai, Stout, C David, Halpert, James R
Published in Molecular pharmacology (01.12.2011)
Published in Molecular pharmacology (01.12.2011)
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Journal Article
Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison
Shah, Manish B, Wilderman, P Ross, Liu, Jingbao, Jang, Hyun-Hee, Zhang, Qinghai, Stout, C David, Halpert, James R
Published in Molecular pharmacology (01.04.2015)
Published in Molecular pharmacology (01.04.2015)
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Journal Article
Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution
Gay, Sean C, Shah, Manish B, Talakad, Jyothi C, Maekawa, Keiko, Roberts, Arthur G, Wilderman, P Ross, Sun, Ling, Yang, Jane Y, Huelga, Stephanie C, Hong, Wen-Xu, Zhang, Qinghai, Stout, C David, Halpert, James R
Published in Molecular pharmacology (01.04.2010)
Published in Molecular pharmacology (01.04.2010)
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Journal Article
A structural snapshot of CYP2B4 in complex with paroxetine provides insights into ligand binding and clusters of conformational states
Shah, Manish B, Kufareva, Irina, Pascual, Jaime, Zhang, Qinghai, Stout, C David, Halpert, James R
Published in The Journal of pharmacology and experimental therapeutics (01.07.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2013)
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Journal Article
Plasticity of Cytochrome P450 2B4 as Investigated by Hydrogen-Deuterium Exchange Mass Spectrometry and X-ray Crystallography
Wilderman, P. Ross, Shah, Manish B., Liu, Tong, Li, Sheng, Hsu, Simon, Roberts, Arthur G., Goodlett, David R., Zhang, Qinghai, Woods, Virgil L., Stout, C. David, Halpert, James R.
Published in The Journal of biological chemistry (03.12.2010)
Published in The Journal of biological chemistry (03.12.2010)
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Journal Article
Effect of detergent binding on cytochrome P450 2B4 structure as analyzed by X-ray crystallography and deuterium-exchange mass spectrometry
Shah, Manish B., Jang, Hyun-Hee, Wilderman, P. Ross, Lee, David, Li, Sheng, Zhang, Qinghai, Stout, C. David, Halpert, James R.
Published in Biophysical chemistry (01.09.2016)
Published in Biophysical chemistry (01.09.2016)
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