Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase
Lira, Ricardo, Xiang, Alan X., Doundoulakis, Thomas, Biller, William T., Agrios, Konstantinos A., Simonsen, Klaus B., Webber, Stephen E., Sisson, Wes, Aust, Robert M., Shah, Amit M., Showalter, Richard E., Banh, Virginia N., Steffy, Kevin R., Appleman, James R.
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
Published in Bioorganic & medicinal chemistry letters (15.12.2007)
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Benny, Rajesh, Singh, Rakeshsingh K., Venkitachalam, Anil, Lalla, Rakesh Shyam, Pandit, Rahul A., Panchal, Keyur C., Pardasani, Vibhor, Chanchalani, Gunjan, Basle, Mheboob, Bolegave, Vyankatesh, Manoj, Hunnur, Shetty, Ashutosh N., Shah, Amit M., Pai, Pawan, Banthia, Nilesh M., Patil, Shekhar G., Chafale, Vishal, Pujara, Bhavin, Shah, Sanjay, Mehta, Naresh, Thakkar, Vicky V., Patel, Vikas, Shetty, Kishore V.
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RUEBSAM, Frank, MURPHY, Douglas E, BLAZEL, Julie K, SUN HEE KIM, YUEFEN ZHOU, QING HAN, KISSINGER, Charles R, WEBBER, Stephen E, SHOWALTER, Richard E, SHAH, Amit M, TSAN, Mei, PATEL, Rupal A, TRAN, Chinh V, THOMPSON, Peggy A, LEBRUN, Laurie A, HOU, Huiying J, KAMRAN, Ruhi, SERGEEVA, Maria V, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, KHANDURINA, Julia, BROOKS, Jennifer, LI, Lian-Sheng, OKAMOTO, Ellen, KIRKOVSKY, Leo, JINGJING ZHAO, DRAGOVICH, Peter S, MCGUIRE, Helen M, XIANG, Alan X, ZHONGXIANG SUN, AYIDA, Benjamin K
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Manipulation of the Membrane Binding Site of Vitamin K-Dependent Proteins: Enhanced Biological Function of Human Factor VII
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Published in Proceedings of the National Academy of Sciences - PNAS (14.04.1998)
Published in Proceedings of the National Academy of Sciences - PNAS (14.04.1998)
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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1' -dioxo-1' 4'-dihydro-1 λ6-benzoll 1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-substitution of benzothiadiazine
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Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase
Ruebsam, Frank, Webber, Stephen E., Tran, Martin T., Tran, Chinh V., Murphy, Douglas E., Zhao, Jingjing, Dragovich, Peter S., Kim, Sun Hee, Li, Lian-Sheng, Zhou, Yuefen, Han, Qing, Kissinger, Charles R., Showalter, Richard E., Lardy, Matthew, Shah, Amit M., Tsan, Mei, Patel, Rupal, LeBrun, Laurie A., Kamran, Ruhi, Sergeeva, Maria V., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Kirkovsky, Leo
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Published in Bioorganic & medicinal chemistry (15.06.2008)
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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments
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Published in Bioorganic & medicinal chemistry letters (01.06.2008)
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1' ,4'-dihydro-1 λ6-benzoll[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2-and 6-pyridazinone substituents
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Published in Bioorganic & medicinal chemistry letters (15.02.2008)
Published in Bioorganic & medicinal chemistry letters (15.02.2008)
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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazinones containing 6-amino-substituents
DRAGOVICH, Peter S, BLAZEL, Julie K, PATEL, Rupal A, RUEBSAM, Frank, SERGEEVA, Maria V, SHAH, Amit M, SHOWALTER, Richard E, TRAN, Chinh V, TSAN, Mei, WEBBER, Stephen E, KIRKOVSKY, Leo, YUEFEN ZHOU, ELLIS, David A, QING HAN, KAMRAN, Ruhi, KISSINGER, Charles R, LEBRUN, Laurie A, LI, Lian-Sheng, MURPHY, Douglas E, NOBLE, Michael
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
Published in Bioorganic & medicinal chemistry letters (15.10.2008)
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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase
Kim, Sun Hee, Tran, Martin T., Ruebsam, Frank, Xiang, Alan X., Ayida, Benjamin, McGuire, Helen, Ellis, David, Blazel, Julie, Tran, Chinh V., Murphy, Douglas E., Webber, Stephen E., Zhou, Yuefen, Shah, Amit M., Tsan, Mei, Showalter, Richard E., Patel, Rupal, Gobbi, Alberto, LeBrun, Laurie A., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Sergeeva, Maria V., Kirkovsky, Leo, Zhao, Qiang, Han, Qing, Kissinger, Charles R.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Ruebsam, Frank, Tran, Chinh V, Li, Lian-Sheng, Kim, Sun Hee, Xiang, Alan X, Zhou, Yuefen, Blazel, Julie K, Sun, Zhongxiang, Dragovich, Peter S, Zhao, Jingjing, McGuire, Helen M, Murphy, Douglas E, Tran, Martin T, Stankovic, Nebojsa, Ellis, David A, Gobbi, Alberto, Showalter, Richard E, Webber, Stephen E, Shah, Amit M, Tsan, Mei, Patel, Rupal A, Lebrun, Laurie A, Hou, Huiying J, Kamran, Ruhi, Sergeeva, Maria V, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Kirkovsky, Leo
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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