Emerging paradigms in GPCR allostery: implications for drug discovery
Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick M
Published in Nature reviews. Drug discovery (01.08.2013)
Published in Nature reviews. Drug discovery (01.08.2013)
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Journal Article
Structural insights into G-protein-coupled receptor allostery
Thal, David M, Glukhova, Alisa, Sexton, Patrick M, Christopoulos, Arthur
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
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Journal Article
Novel Allosteric Modulators of G Protein-coupled Receptors
Gentry, Patrick R., Sexton, Patrick M., Christopoulos, Arthur
Published in The Journal of biological chemistry (07.08.2015)
Published in The Journal of biological chemistry (07.08.2015)
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Journal Article
Allostery and Biased Agonism at Class B G Protein-Coupled Receptors
Wootten, Denise, Miller, Laurence J, Koole, Cassandra, Christopoulos, Arthur, Sexton, Patrick M
Published in Chemical reviews (11.01.2017)
Published in Chemical reviews (11.01.2017)
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Journal Article
Muscarinic acetylcholine receptors: novel opportunities for drug development
Kruse, Andrew C, Kobilka, Brian K, Gautam, Dinesh, Sexton, Patrick M, Christopoulos, Arthur, Wess, Jürgen
Published in Nature reviews. Drug discovery (01.07.2014)
Published in Nature reviews. Drug discovery (01.07.2014)
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Journal Article
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex
Liang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M, Furness, Sebastian G B, Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J, Christopoulos, Arthur, Kobilka, Brian K, Wootten, Denise, Skiniotis, Georgios, Sexton, Patrick M
Published in Nature (London) (01.06.2017)
Published in Nature (London) (01.06.2017)
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Journal Article
Structure of the Adenosine A1 Receptor Reveals the Basis for Subtype Selectivity
Glukhova, Alisa, Thal, David M., Nguyen, Anh T., Vecchio, Elizabeth A., Jörg, Manuela, Scammells, Peter J., May, Lauren T., Sexton, Patrick M., Christopoulos, Arthur
Published in Cell (23.02.2017)
Published in Cell (23.02.2017)
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Journal Article
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity
Mobbs, Jesse I, Belousoff, Matthew J, Harikumar, Kaleeckal G, Piper, Sarah J, Xu, Xiaomeng, Furness, Sebastian G B, Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M, Miller, Laurence J, Sexton, Patrick M
Published in PLoS biology (01.06.2021)
Published in PLoS biology (01.06.2021)
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Journal Article
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex
Liang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G B, Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T, Thal, David M, Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J, Christopoulos, Arthur, Sexton, Patrick M, Wootten, Denise
Published in Nature (London) (01.03.2018)
Published in Nature (London) (01.03.2018)
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Journal Article
Activation and allosteric modulation of a muscarinic acetylcholine receptor
Kruse, Andrew C, Ring, Aaron M, Manglik, Aashish, Hu, Jianxin, Hu, Kelly, Eitel, Katrin, Hübner, Harald, Pardon, Els, Valant, Celine, Sexton, Patrick M, Christopoulos, Arthur, Felder, Christian C, Gmeiner, Peter, Steyaert, Jan, Weis, William I, Garcia, K Christopher, Wess, Jürgen, Kobilka, Brian K
Published in Nature (London) (05.12.2013)
Published in Nature (London) (05.12.2013)
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Journal Article
Bridging the gap: bitopic ligands of G-protein-coupled receptors
Lane, J. Robert, Sexton, Patrick M, Christopoulos, Arthur
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2013)
Published in Trends in pharmacological sciences (Regular ed.) (01.01.2013)
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Journal Article
Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S., Radjainia, Mazdak, Plitzko, Jürgen M., Baumeister, Wolfgang, Miller, Laurence J., Hay, Deborah L., Christopoulos, Arthur, Reynolds, Christopher A., Wootten, Denise, Sexton, Patrick M.
Published in Nature (London) (01.09.2018)
Published in Nature (London) (01.09.2018)
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Comparative genotypic and phenotypic analysis of human peripheral blood monocytes and surrogate monocyte-like cell lines commonly used in metabolic disease research
Riddy, Darren M, Goy, Emily, Delerive, Philippe, Summers, Roger J, Sexton, Patrick M, Langmead, Christopher J
Published in PloS one (10.05.2018)
Published in PloS one (10.05.2018)
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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Published in Cell (16.06.2016)
Published in Cell (16.06.2016)
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Journal Article
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations
Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (26.03.2013)
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Journal Article
Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor
Khajehali, Elham, Malone, Daniel T, Glass, Michelle, Sexton, Patrick M, Christopoulos, Arthur, Leach, Katie
Published in Molecular pharmacology (01.08.2015)
Published in Molecular pharmacology (01.08.2015)
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