Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation
Hanan, Emily J, Eigenbrot, Charles, Bryan, Marian C, Burdick, Daniel J, Chan, Bryan K, Chen, Yuan, Dotson, Jennafer, Heald, Robert A, Jackson, Philip S, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
Get full text
Journal Article
Potent and Highly Selective Benzimidazole Inhibitors of PI3-Kinase Delta
Murray, Jeremy M, Sweeney, Zachary K, Chan, Bryan K, Balazs, Mercedesz, Bradley, Erin, Castanedo, Georgette, Chabot, Christine, Chantry, David, Flagella, Michael, Goldstein, David M, Kondru, Rama, Lesnick, John, Li, Jun, Lucas, Matthew C, Nonomiya, Jim, Pang, Jodie, Price, Stephen, Salphati, Laurent, Safina, Brian, Savy, Pascal P. A, Seward, Eileen M, Ultsch, Mark, Sutherlin, Daniel P
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
Get full text
Journal Article
Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor
Chan, Bryan K, Hanan, Emily J, Bowman, Krista K, Bryan, Marian C, Burdick, Daniel, Chan, Emily, Chen, Yuan, Clausen, Saundra, Dela Vega, Trisha, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard L, Heald, Robert A, Jackson, Philip S, Knight, Jamie D, La, Hank, Lainchbury, Michael D, Malek, Shiva, Purkey, Hans E, Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M, Sideris, Steve, Shao, Lily, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yu, Christine, Heffron, Timothy P
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
Get full text
Journal Article
Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition
Safina, Brian S, Baker, Stewart, Baumgardner, Matt, Blaney, Paul M, Chan, Bryan K, Chen, Yung-Hsiang, Cartwright, Matthew W, Castanedo, Georgette, Chabot, Christine, Cheguillaume, Arnaud J, Goldsmith, Paul, Goldstein, David M, Goyal, Bindu, Hancox, Timothy, Handa, Raj K, Iyer, Pravin S, Kaur, Jasmit, Kondru, Rama, Kenny, Jane R, Krintel, Sussie L, Li, Jun, Lesnick, John, Lucas, Matthew C, Lewis, Cristina, Mukadam, Sophie, Murray, Jeremy, Nadin, Alan J, Nonomiya, Jim, Padilla, Fernando, Palmer, Wylie S, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Salphati, Laurent, Savy, Pascal A, Seward, Eileen M, Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K, Tay, Suzanne, Tivitmahaisoon, Parcharee, Waszkowycz, Bohdan, Wei, Binqing, Yue, Qin, Zhang, Chenghong, Sutherlin, Daniel P
Published in Journal of medicinal chemistry (28.06.2012)
Published in Journal of medicinal chemistry (28.06.2012)
Get full text
Journal Article
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles
Safina, Brian S, Elliott, Richard L, Forrest, Andrew K, Heald, Robert A, Murray, Jeremy M, Nonomiya, Jim, Pang, Jodie, Salphati, Laurent, Seward, Eileen M, Staben, Steven T, Ultsch, Mark, Wei, Binqing, Yang, Wenqian, Sutherlin, Daniel P
Published in ACS medicinal chemistry letters (14.09.2017)
Published in ACS medicinal chemistry letters (14.09.2017)
Get full text
Journal Article
Potent and selective inhibitors of PI3Kδ: Obtaining isoform selectivity from the affinity pocket and tryptophan shelf
Sutherlin, Daniel P., Baker, Stewart, Bisconte, Angelina, Blaney, Paul M., Brown, Anthony, Chan, Bryan K., Chantry, David, Castanedo, Georgette, DePledge, Paul, Goldsmith, Paul, Goldstein, David M., Hancox, Timothy, Kaur, Jasmit, Knowles, David, Kondru, Rama, Lesnick, John, Lucas, Matthew C., Lewis, Cristina, Murray, Jeremy, Nadin, Alan J., Nonomiya, Jim, Pang, Jodie, Pegg, Neil, Price, Steve, Reif, Karin, Safina, Brian S., Salphati, Laurent, Staben, Steven, Seward, Eileen M., Shuttleworth, Stephen, Sohal, Sukhjit, Sweeney, Zachary K., Ultsch, Mark, Waszkowycz, Bohdan, Wei, Binqing
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Published in Bioorganic & medicinal chemistry letters (01.07.2012)
Get full text
Journal Article
Identification of GNE-293, a potent and selective PI3Kδ inhibitor: Navigating in vitro genotoxicity while improving potency and selectivity
Safina, Brian S., Sweeney, Zachary K., Li, Jun, Chan, Bryan K., Bisconte, Angelina, Carrera, Diane, Castanedo, Georgette, Flagella, Michael, Heald, Robert, Lewis, Cristina, Murray, Jeremy M., Nonomiya, Jim, Pang, Jodie, Price, Steve, Reif, Karin, Salphati, Laurent, Seward, Eileen M., Wei, Binqing, Sutherlin, Daniel P.
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Get full text
Journal Article
Substituent Effects on Edge-to-Face Aromatic Interactions
Carver, Fiona J., Hunter, Christopher A., Livingstone, David J., McCabe, James F., Seward, Eileen M.
Published in Chemistry : a European journal (03.07.2002)
Published in Chemistry : a European journal (03.07.2002)
Get full text
Journal Article
유로리틴 유도체 및 이의 사용 방법
KNIGHT JAMIE D, SENNHENN PETER C, BEAUFILS FLORENT, SUTTON JONATHAN MARK, RINSCH CHRISTOPHER L, LINNEY IAN, ANDREUX PENELOPE, SEWARD EILEEN M, OUMOUCH SAID, FESSARD THOMAS CHRISTIAN
Year of Publication 06.11.2023
Get full text
Year of Publication 06.11.2023
Patent
Redox-dependent binding ability of a flavin cyclophane in aqueous solution: hydrophobic stacking versus cavity-inclusion complexation
Seward, Eileen M, Hopkins, R. Bruce, Sauerer, Wolfgang, Tam, Suk Wah, Diederich, Francois
Published in Journal of the American Chemical Society (01.02.1990)
Published in Journal of the American Chemical Society (01.02.1990)
Get full text
Journal Article
Spirocyclic NK1 antagonists I:[4.5] and [5.5]-spiroketals
SEWARD, Eileen M, CARLSON, Emma, SADOWSKI, Sharon J, SWAIN, Christopher J, WILLIAMS, Brian J, HARRISON, Timothy, HAWORTH, Karen E, HERBERT, Richard, KELLEHER, Fintan J, KURTZ, Marc M, MOSELEY, Jonathan, OWEN, Simon N, OWENS, Andrew P
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Get full text
Journal Article
AMINOPYRIMIDINE COMPOUNDS AS INHIBITORS OF T790M CONTAINING EGFR MUTANTS
BRYAN MARIAN C, CHAN BRYAN, LAINCHBURY MICHAEL, ELLIOTT RICHARD LEONARD, KNIGHT JAMIE, HANAN EMILY, SEWARD EILEEN M, HEFFRON TIMOTHY, PURKEY HANS, HEALD ROBERT
Year of Publication 30.07.2015
Get full text
Year of Publication 30.07.2015
Patent
HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS
SAFINA BRIAN, SUTHERLIN DANIEL P, PRICE STEPHEN, SEWARD EILEEN M, SAVY PASCAL PIERRE ALEXANDRE, WASZKOWYCZ BOHDAN, HEALD ROBERT
Year of Publication 23.10.2013
Get full text
Year of Publication 23.10.2013
Patent
BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE
ELLIOTT RICHARD, WEI BINQING, SAFINA BRIAN, GANCIA EMANUELA, SUTHERLIN DANIEL P, STABEN STEVEN, SEWARD EILEEN M, HEFFRON TIMOTHY, WASZKOWYCZ BOHDAN, HEALD ROBERT
Year of Publication 14.03.2014
Get full text
Year of Publication 14.03.2014
Patent
Synthesis, X-ray crystal structures, and cation transfer properties of alkyl calixaryl acetates, a new series of molecular receptors
MCKERVEY, M. A, SEWARD, E. M, FERGUSON, G, RUHL, B, HARRIS, S. J
Published in Journal of the Chemical Society. Chemical communications (1985)
Published in Journal of the Chemical Society. Chemical communications (1985)
Get full text
Journal Article
Cation complexation by chemically modified calixarenes. Part 7. Transport of alkali cations by p-tert-butylcalix[n]arene esters and amides
Arnaud-Neu, Fran oise, Fanni, Stefano, Guerra, Lourdes, McGregor, William, Ziat, Khadija, Schwing-Weill, Marie-Jos, Barrett, Geraldine, McKervey, M. Anthony, Marrs, Deborah, Seward, Eileen M.
Published in Journal of the Chemical Society, Perkin Transactions 2 (1995)
Published in Journal of the Chemical Society, Perkin Transactions 2 (1995)
Get full text
Journal Article