A Non–D2-Receptor-Binding Drug for the Treatment of Schizophrenia
Koblan, Kenneth S, Kent, Justine, Hopkins, Seth C, Krystal, John H, Cheng, Hailong, Goldman, Robert, Loebel, Antony
Published in The New England journal of medicine (16.04.2020)
Published in The New England journal of medicine (16.04.2020)
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Journal Article
Ulotaront: review of preliminary evidence for the efficacy and safety of a TAAR1 agonist in schizophrenia
Achtyes, Eric D., Hopkins, Seth C., Dedic, Nina, Dworak, Heather, Zeni, Courtney, Koblan, Kenneth
Published in European archives of psychiatry and clinical neuroscience (01.10.2023)
Published in European archives of psychiatry and clinical neuroscience (01.10.2023)
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Journal Article
Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans
Hopkins, Seth C., Dedic, Nina, Koblan, Kenneth S.
Published in Translational psychiatry (20.04.2021)
Published in Translational psychiatry (20.04.2021)
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Journal Article
A randomized, single‐dose, crossover study of the effects of ulotaront on electrocardiogram intervals in subjects with schizophrenia
Tsukada, Hironobu, Milanovic, Snezana M., Darpo, Borje, Xue, Hongqi, Xiong, Kuangnan, Tripp, Emily, Lennek, Lisa, Worden, MaryAlice, Hopkins, Seth C., Galluppi, Gerald R.
Published in Clinical and translational science (01.06.2023)
Published in Clinical and translational science (01.06.2023)
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Journal Article
TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding
Dedic, Nina, Wang, Lien, Hajos-Korcsok, Eva, Hecksher-Sørensen, Jacob, Roostalu, Urmas, Vickers, Steven P., Wu, Serena, Anacker, Christoph, Synan, Colleen, Jones, Philip G., Milanovic, Snezana, Hopkins, Seth C., Bristow, Linda J., Koblan, Kenneth S.
Published in Molecular metabolism (Germany) (01.02.2024)
Published in Molecular metabolism (Germany) (01.02.2024)
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Journal Article
Evaluation of OCT2‐mediated drug–drug interactions between ulotaront and metformin in subjects with schizophrenia
Xiao, Guangqing, Tsukada, Hironobu, Chen, Yu‐Luan, Shi, Lei, Hopkins, Seth C., Galluppi, Gerald R.
Published in Pharmacology research & perspectives (01.04.2024)
Published in Pharmacology research & perspectives (01.04.2024)
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Journal Article
Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy
Perini, Francesca, Nazimek, Jadwiga Maria, Mckie, Shane, Capitão, Liliana P., Scaife, Jessica, Pal, Deepa, Browning, Michael, Dawson, Gerard R., Nishikawa, Hiroyuki, Campbell, Una, Hopkins, Seth C., Loebel, Antony, Elliott, Rebecca, Harmer, Catherine J., Deakin, Bill, Koblan, Kenneth S.
Published in NPJ schizophrenia (07.08.2023)
Published in NPJ schizophrenia (07.08.2023)
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Journal Article
Structural, Kinetic, and Pharmacodynamic Mechanisms of d‑Amino Acid Oxidase Inhibition by Small Molecules
Hopkins, Seth C, Heffernan, Michele L. R, Saraswat, Lakshmi D, Bowen, Carrie A, Melnick, Laurence, Hardy, Larry W, Orsini, Michael A, Allen, Michael S, Koch, Patrick, Spear, Kerry L, Foglesong, Robert J, Soukri, Mustapha, Chytil, Milan, Fang, Q. Kevin, Jones, Steven W, Varney, Mark A, Panatier, Aude, Oliet, Stephane H. R, Pollegioni, Loredano, Piubelli, Luciano, Molla, Gianluca, Nardini, Marco, Large, Thomas H
Published in Journal of medicinal chemistry (09.05.2013)
Published in Journal of medicinal chemistry (09.05.2013)
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Journal Article
Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain
Hopkins, Seth C, Zhao, Fei-Yue, Bowen, Carrie A, Fang, Xin, Wei, Haifeng, Heffernan, Michele L R, Spear, Kerry L, Spanswick, David C, Varney, Mark A, Large, Thomas H
Published in The Journal of pharmacology and experimental therapeutics (01.06.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.06.2013)
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Journal Article
Challenges in the clinical development of non-D2 compounds for schizophrenia
Hopkins, Seth C., Lew, Robert, Zeni, Courtney, Koblan, Kenneth S.
Published in Current medical research and opinion (04.03.2023)
Published in Current medical research and opinion (04.03.2023)
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Journal Article
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action
Dedic, Nina, Jones, Philip G, Hopkins, Seth C, Lew, Robert, Shao, Liming, Campbell, John E, Spear, Kerry L, Large, Thomas H, Campbell, Una C, Hanania, Taleen, Leahy, Emer, Koblan, Kenneth S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Journal Article
SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D 2 Receptor Mechanism of Action
Dedic, Nina, Jones, Philip G, Hopkins, Seth C, Lew, Robert, Shao, Liming, Campbell, John E, Spear, Kerry L, Large, Thomas H, Campbell, Una C, Hanania, Taleen, Leahy, Emer, Koblan, Kenneth S
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
Published in The Journal of pharmacology and experimental therapeutics (01.10.2019)
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Journal Article
A Randomized, Double-blind, Placebo-controlled Proof-of-Concept Trial to Evaluate the Efficacy and Safety of Non-racemic Amisulpride (SEP-4199) for the Treatment of Bipolar I Depression
Loebel, Antony, Koblan, Kenneth S., Tsai, Joyce, Deng, Ling, Fava, Maurizio, Kent, Justine, Hopkins, Seth C.
Published in Journal of affective disorders (01.01.2022)
Published in Journal of affective disorders (01.01.2022)
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Journal Article
Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine
Kokkinou, Michelle, Irvine, Elaine E., Bonsall, David R., Natesan, Sridhar, Wells, Lisa A., Smith, Mark, Glegola, Justyna, Paul, Eleanor J., Tossell, Kyoko, Veronese, Mattia, Khadayate, Sanjay, Dedic, Nina, Hopkins, Seth C., Ungless, Mark A., Withers, Dominic J., Howes, Oliver D.
Published in Molecular psychiatry (01.06.2021)
Published in Molecular psychiatry (01.06.2021)
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Journal Article
Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5‐HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders
Hopkins, Seth C., Wilkinson, Scott, Corriveau, Taryn J., Nishikawa, Hiroyuki, Nakamichi, Keiko, Loebel, Antony, Koblan, Kenneth S.
Published in Clinical pharmacology and therapeutics (01.09.2021)
Published in Clinical pharmacology and therapeutics (01.09.2021)
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Journal Article
TAAR1 agonist ulotaront delays gastric emptying of solids in patients with schizophrenia and concurrent metabolic syndrome with prediabetes
Milanović, Snežana, Dedic, Nina, Lew, Robert, Burton, Duane, Koblan, Kenneth S., Camilleri, Michael, Hopkins, Seth C.
Published in Diabetes, obesity & metabolism (01.06.2024)
Published in Diabetes, obesity & metabolism (01.06.2024)
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