Single-cell RNA sequencing reveals distinct tumor microenvironmental patterns in lung adenocarcinoma
Bischoff, Philip, Trinks, Alexandra, Obermayer, Benedikt, Pett, Jan Patrick, Wiederspahn, Jennifer, Uhlitz, Florian, Liang, Xizi, Lehmann, Annika, Jurmeister, Philipp, Elsner, Aron, Dziodzio, Tomasz, Rückert, Jens-Carsten, Neudecker, Jens, Falk, Christine, Beule, Dieter, Sers, Christine, Morkel, Markus, Horst, David, Blüthgen, Nils, Klauschen, Frederick
Published in Oncogene (16.12.2021)
Published in Oncogene (16.12.2021)
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Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
Brandt, Raphael, Sell, Thomas, Lüthen, Mareen, Uhlitz, Florian, Klinger, Bertram, Riemer, Pamela, Giesecke-Thiel, Claudia, Schulze, Silvia, El-Shimy, Ismail Amr, Kunkel, Desiree, Fauler, Beatrix, Mielke, Thorsten, Mages, Norbert, Herrmann, Bernhard G., Sers, Christine, Blüthgen, Nils, Morkel, Markus
Published in Nature communications (02.07.2019)
Published in Nature communications (02.07.2019)
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Patient-derived xenograft (PDX) models of colorectal carcinoma (CRC) as a platform for chemosensitivity and biomarker analysis in personalized medicine
Rivera, Maria, Fichtner, Iduna, Wulf-Goldenberg, Annika, Sers, Christine, Merk, Johannes, Patone, Giannino, Alp, Keziban M., Kanashova, Tamara, Mertins, Philipp, Hoffmann, Jens, Stein, Ulrike, Walther, Wolfgang
Published in Neoplasia (New York, N.Y.) (01.01.2021)
Published in Neoplasia (New York, N.Y.) (01.01.2021)
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Mitogen‐activated protein kinase activity drives cell trajectories in colorectal cancer
Uhlitz, Florian, Bischoff, Philip, Peidli, Stefan, Sieber, Anja, Trinks, Alexandra, Lüthen, Mareen, Obermayer, Benedikt, Blanc, Eric, Ruchiy, Yana, Sell, Thomas, Mamlouk, Soulafa, Arsie, Roberto, Wei, Tzu‐Ting, Klotz‐Noack, Kathleen, Schwarz, Roland F, Sawitzki, Birgit, Kamphues, Carsten, Beule, Dieter, Landthaler, Markus, Sers, Christine, Horst, David, Blüthgen, Nils, Morkel, Markus
Published in EMBO molecular medicine (07.10.2021)
Published in EMBO molecular medicine (07.10.2021)
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Ras-mediated deregulation of the circadian clock in cancer
Relógio, Angela, Thomas, Philippe, Medina-Pérez, Paula, Reischl, Silke, Bervoets, Sander, Gloc, Ewa, Riemer, Pamela, Mang-Fatehi, Shila, Maier, Bert, Schäfer, Reinhold, Leser, Ulf, Herzel, Hanspeter, Kramer, Achim, Sers, Christine
Published in PLoS genetics (01.05.2014)
Published in PLoS genetics (01.05.2014)
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An Alu element-associated hypermethylation variant of the POMC gene is associated with childhood obesity
Kuehnen, Peter, Mischke, Mona, Wiegand, Susanna, Sers, Christine, Horsthemke, Bernhard, Lau, Susanne, Keil, Thomas, Lee, Young-Ae, Grueters, Annette, Krude, Heiko
Published in PLoS genetics (01.03.2012)
Published in PLoS genetics (01.03.2012)
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Journal Article
Mutational Diversity and Therapy Response in Breast Cancer: A Sequencing Analysis in the Neoadjuvant GeparSepto Trial
Loibl, Sibylle, Treue, Denise, Budczies, Jan, Weber, Karsten, Stenzinger, Albrecht, Schmitt, Wolfgang D, Weichert, Wilko, Jank, Paul, Furlanetto, Jenny, Klauschen, Frederick, Karn, Thomas, Pfarr, Nicole, von Minckwitz, Gunter, Möbs, Markus, Jackisch, Christian, Sers, Christine, Schneeweiss, Andreas, Fasching, Peter A, Schem, Christian, Hummel, Michael, van Mackelenbergh, Marion, Nekljudova, Valentina, Untch, Michael, Denkert, Carsten
Published in Clinical cancer research (01.07.2019)
Published in Clinical cancer research (01.07.2019)
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Journal Article
The majority of β-catenin mutations in colorectal cancer is homozygous
Arnold, Alexander, Tronser, Moritz, Sers, Christine, Ahadova, Aysel, Endris, Volker, Mamlouk, Soulafa, Horst, David, Möbs, Markus, Bischoff, Philip, Kloor, Matthias, Bläker, Hendrik
Published in BMC cancer (28.10.2020)
Published in BMC cancer (28.10.2020)
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Journal Article
Network quantification of EGFR signaling unveils potential for targeted combination therapy
Klinger, Bertram, Sieber, Anja, Fritsche‐Guenther, Raphaela, Witzel, Franziska, Berry, Leanne, Schumacher, Dirk, Yan, Yibing, Durek, Pawel, Merchant, Mark, Schäfer, Reinhold, Sers, Christine, Blüthgen, Nils
Published in Molecular systems biology (2013)
Published in Molecular systems biology (2013)
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Journal Article
Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
Fritsche‐Guenther, Raphaela, Witzel, Franziska, Sieber, Anja, Herr, Ricarda, Schmidt, Nadine, Braun, Sandra, Brummer, Tilman, Sers, Christine, Blüthgen, Nils
Published in Molecular systems biology (24.05.2011)
Published in Molecular systems biology (24.05.2011)
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Journal Article
DNA methylation profiling reliably distinguishes pulmonary enteric adenocarcinoma from metastatic colorectal cancer
Jurmeister, Philipp, Schöler, Anne, Arnold, Alexander, Klauschen, Frederick, Lenze, Dido, Hummel, Michael, Schweizer, Leonille, Bläker, Hendrik, Pfitzner, Berit Maria, Mamlouk, Soulafa, Sers, Christine, Denkert, Carsten, Stichel, Damian, Frost, Nikolaj, Horst, David, von Laffert, Maximilian, Capper, David
Published in Modern pathology (01.06.2019)
Published in Modern pathology (01.06.2019)
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DNA copy number changes define spatial patterns of heterogeneity in colorectal cancer
Mamlouk, Soulafa, Childs, Liam Harold, Aust, Daniela, Heim, Daniel, Melching, Friederike, Oliveira, Cristiano, Wolf, Thomas, Durek, Pawel, Schumacher, Dirk, Bläker, Hendrik, von Winterfeld, Moritz, Gastl, Bastian, Möhr, Kerstin, Menne, Andrea, Zeugner, Silke, Redmer, Torben, Lenze, Dido, Tierling, Sascha, Möbs, Markus, Weichert, Wilko, Folprecht, Gunnar, Blanc, Eric, Beule, Dieter, Schäfer, Reinhold, Morkel, Markus, Klauschen, Frederick, Leser, Ulf, Sers, Christine
Published in Nature communications (25.01.2017)
Published in Nature communications (25.01.2017)
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Journal Article
Increased expression of IDO1 is associated with improved survival and increased number of TILs in patients with high-grade serous ovarian cancer
Hoffmann, Inga, Dragomir, Mihnea P., Monjé, Nanna, Keunecke, Carlotta, Kunze, Catarina Alisa, Schallenberg, Simon, Marchenko, Sofya, Schmitt, Wolfgang D., Kulbe, Hagen, Sehouli, Jalid, Braicu, Ioana Elena, Jank, Paul, Denkert, Carsten, Darb-Esfahani, Silvia, Horst, David, Sinn, Bruno V., Sers, Christine, Bischoff, Philip, Taube, Eliane T.
Published in Neoplasia (New York, N.Y.) (01.10.2023)
Published in Neoplasia (New York, N.Y.) (01.10.2023)
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Journal Article
Malignant transformation and genetic alterations are uncoupled in early colorectal cancer progression
Mamlouk, Soulafa, Simon, Tincy, Tomás, Laura, Wedge, David C, Arnold, Alexander, Menne, Andrea, Horst, David, Capper, David, Morkel, Markus, Posada, David, Sers, Christine, Bläker, Hendrik
Published in BMC biology (07.09.2020)
Published in BMC biology (07.09.2020)
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Journal Article
Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations
Fritsche-Guenther, Raphaela, Zasada, Christin, Mastrobuoni, Guido, Royla, Nadine, Rainer, Roman, Roßner, Florian, Pietzke, Matthias, Klipp, Edda, Sers, Christine, Kempa, Stefan
Published in Scientific reports (15.06.2018)
Published in Scientific reports (15.06.2018)
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Journal Article
Evaluating Uncertainty in Signaling Networks Using Logical Modeling
Thobe, Kirsten, Kuznia, Christina, Sers, Christine, Siebert, Heike
Published in Frontiers in physiology (09.10.2018)
Published in Frontiers in physiology (09.10.2018)
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Journal Article
A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages
Klotz, Christian, Ziegler, Thomas, Figueiredo, Ana Sofia, Rausch, Sebastian, Hepworth, Matthew R, Obsivac, Nadja, Sers, Christine, Lang, Roland, Hammerstein, Peter, Lucius, Richard, Hartmann, Susanne
Published in PLoS pathogens (01.01.2011)
Published in PLoS pathogens (01.01.2011)
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Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
Solvay, Marie, Holfelder, Pauline, Klaessens, Simon, Pilotte, Luc, Stroobant, Vincent, Lamy, Juliette, Naulaerts, Stefan, Spillier, Quentin, Frédérick, Raphaël, De Plaen, Etienne, Sers, Christine, Opitz, Christiane A, Van den Eynde, Benoit J, Zhu, Jingjing
Published in Journal for immunotherapy of cancer (01.06.2023)
Published in Journal for immunotherapy of cancer (01.06.2023)
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