5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates
Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Get full text
Journal Article
Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice
Michler, Thomas, Kosinska, Anna D., Festag, Julia, Bunse, Till, Su, Jinpeng, Ringelhan, Marc, Imhof, Hortenzia, Grimm, Dirk, Steiger, Katja, Mogler, Carolin, Heikenwalder, Mathias, Michel, Marie-Louise, Guzman, Carlos A., Milstein, Stuart, Sepp-Lorenzino, Laura, Knolle, Percy, Protzer, Ulrike
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2020)
Get full text
Journal Article
Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment
Abrams, Marc T, Koser, Martin L, Seitzer, Jessica, Williams, Stephanie C, DiPietro, Martha A, Wang, Weimin, Shaw, Andrew W, Mao, Xianzhi, Jadhav, Vasant, Davide, Joseph P, Burke, Paul A, Sachs, Alan B, Stirdivant, Steven M, Sepp-Lorenzino, Laura
Published in Molecular therapy (01.01.2010)
Published in Molecular therapy (01.01.2010)
Get full text
Journal Article
Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth
Khan, Tayeba, Weber, Hans, DiMuzio, Jillian, Matter, Andrea, Dogdas, Belma, Shah, Tosha, Thankappan, Anil, Disa, Jyoti, Jadhav, Vasant, Lubbers, Laura, Sepp-Lorenzino, Laura, Strapps, Walter R, Tadin-Strapps, Marija
Published in Molecular therapy. Nucleic acids (02.08.2016)
Published in Molecular therapy. Nucleic acids (02.08.2016)
Get full text
Journal Article
Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage
Tao, Weikang, South, Victoria J., Zhang, Yun, Davide, Joseph P., Farrell, Linda, Kohl, Nancy E., Sepp-Lorenzino, Laura, Lobell, Robert B.
Published in Cancer cell (01.07.2005)
Published in Cancer cell (01.07.2005)
Get full text
Journal Article
Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation
Ng, Bruce, Cash-Mason, Tanesha, Wang, Yi, Seitzer, Jessica, Burchard, Julja, Brown, Duncan, Dudkin, Vadim, Davide, Joseph, Jadhav, Vasant, Sepp-Lorenzino, Laura, Cejas, Pedro J.
Published in Molecular therapy. Nucleic acids (07.06.2019)
Published in Molecular therapy. Nucleic acids (07.06.2019)
Get full text
Journal Article
Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses
Tao, Weikang, Mao, Xianzhi, Davide, Joseph P, Ng, Bruce, Cai, Mingmei, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura
Published in Molecular therapy (01.03.2011)
Published in Molecular therapy (01.03.2011)
Get full text
Journal Article
Quantitative evaluation of siRNA delivery in vivo
Pei, Yi, Hancock, Paula J, Zhang, Hangchun, Bartz, René, Cherrin, Craig, Innocent, Nathalie, Pomerantz, Colin J, Seitzer, Jessica, Koser, Martin L, Abrams, Marc T, Xu, Yan, Kuklin, Nelly A, Burke, Paul A, Sachs, Alan B, Sepp-Lorenzino, Laura, Barnett, Stanley F
Published in RNA (Cambridge) (01.12.2010)
Published in RNA (Cambridge) (01.12.2010)
Get full text
Journal Article
Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape
Bartz, René, Fan, Haihong, Zhang, Jingtao, Innocent, Nathalie, Cherrin, Craig, Beck, Stephen C, Pei, Yi, Momose, Aaron, Jadhav, Vasant, Tellers, David M, Meng, Fanyu, Crocker, Louis S, Sepp-Lorenzino, Laura, Barnett, Stanley F
Published in Biochemical journal (15.04.2011)
Published in Biochemical journal (15.04.2011)
Get more information
Journal Article
Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing
Chang, Wonsuk, Pei, Yi, Guidry, Erin N., Zewge, Daniel, Parish, Craig A., Sherer, Edward C., DiMuzio, Jillian, Zhang, Hangchun, South, Victoria J., Strapps, Walter R., Sepp-Lorenzino, Laura, Colletti, Steven L., Stanton, Matthew G.
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
Published in Bioorganic & medicinal chemistry letters (15.09.2016)
Get full text
Journal Article
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
Cherrin, Craig, Haskell, Kathleen, Howell, Bonnie, Jones, Raymond, Leander, Karen, Robinson, Ronald, Watkins, Aubrey, Bilodeau, Mark, Hoffman, Jacob, Sanderson, Philip, Hartman, George, Mahan, Elizabeth, Prueksaritanont, Thomayant, Jiang, Guoqiang, She, Qing-Bai, Rosen, Neal, Sepp-Lorenzino, Laura, Defeo-Jones, Deborah, Huber, Hans E.
Published in Cancer biology & therapy (01.04.2010)
Published in Cancer biology & therapy (01.04.2010)
Get full text
Journal Article
Inside Cover: 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates (ChemBioChem 11/2016)
Parmar, Rubina, Willoughby, Jennifer L. S., Liu, Jingxuan, Foster, Donald J., Brigham, Benjamin, Theile, Christopher S., Charisse, Klaus, Akinc, Akin, Guidry, Erin, Pei, Yi, Strapps, Walter, Cancilla, Mark, Stanton, Matthew G., Rajeev, Kallanthottathil G., Sepp-Lorenzino, Laura, Manoharan, Muthiah, Meyers, Rachel, Maier, Martin A., Jadhav, Vasant
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Published in Chembiochem : a European journal of chemical biology (02.06.2016)
Get full text
Journal Article
An Inhibitor of the Kinesin Spindle Protein Activates the Intrinsic Apoptotic Pathway Independently of p53 and De Novo Protein Synthesis
Tao, Weikang, South, Victoria J., Diehl, Ronald E., Davide, Joseph P., Sepp-Lorenzino, Laura, Fraley, Mark E., Arrington, Kenneth L., Lobell, Robert B.
Published in Molecular and Cellular Biology (01.01.2007)
Published in Molecular and Cellular Biology (01.01.2007)
Get full text
Journal Article
Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit
Chen, Zhu, Luo, Bin, Cai, Tian-Quan, Thankappan, Anil, Xu, Yiming, Wu, Weizhen, DiMuzio, Jillian, Lifsted, Traci, DiPietro, Marty, Disa, Jyoti, Ng, Bruce, Leander, Karen, Clark, Seth, Hoos, Lizbeth, Zhou, Yuchen, Jochnowitz, Nina, Jachec, Christine, Szczerba, Peter, Gindy, Marian E, Strapps, Walter, Sepp-Lorenzino, Laura, Seiffert, Dietmar A, Lubbers, Laura, Tadin-Strapps, Marija
Published in Molecular therapy. Nucleic acids (01.01.2015)
Published in Molecular therapy. Nucleic acids (01.01.2015)
Get full text
Journal Article
Pharmacologic Shifting of a Balance between Protein Refolding and Degradation Mediated by Hsp90
Schneider, Christine, Sepp-Lorenzino, Laura, Nimmesgern, Elmar, Ouerfelli, Ouathek, Danishefsky, Samuel, Rosen, Neal, Hartl, F. Ulrich
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.1996)
Published in Proceedings of the National Academy of Sciences - PNAS (10.12.1996)
Get full text
Journal Article