Antibody–drug conjugates come of age in oncology
Dumontet, Charles, Reichert, Janice M., Senter, Peter D., Lambert, John M., Beck, Alain
Published in Nature reviews. Drug discovery (01.08.2023)
Published in Nature reviews. Drug discovery (01.08.2023)
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Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index
Lyon, Robert P, Bovee, Tim D, Doronina, Svetlana O, Burke, Patrick J, Hunter, Joshua H, Neff-LaFord, Haley D, Jonas, Mechthild, Anderson, Martha E, Setter, Jocelyn R, Senter, Peter D
Published in Nature biotechnology (01.07.2015)
Published in Nature biotechnology (01.07.2015)
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Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates
Levengood, Matthew R., Zhang, Xinqun, Hunter, Joshua H., Emmerton, Kim K., Miyamoto, Jamie B., Lewis, Timothy S., Senter, Peter D.
Published in Angewandte Chemie International Edition (16.01.2017)
Published in Angewandte Chemie International Edition (16.01.2017)
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Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate
OKELEY, Nicole M, MIYAMOTO, Jamie B, XINQUN ZHANG, SANDERSON, Russell J, BENJAMIN, Dennis R, SIEVERS, Eric L, SENTER, Peter D, ALLEY, Stephen C
Published in Clinical cancer research (01.02.2010)
Published in Clinical cancer research (01.02.2010)
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A coiled-coil masking domain for selective activation of therapeutic antibodies
Trang, Vivian H., Zhang, Xinqun, Yumul, Roma C., Zeng, Weiping, Stone, Ivan J., Wo, Serena W., Dominguez, Melissa M., Cochran, Julia H., Simmons, Jessica K., Ryan, Maureen C., Lyon, Robert P., Senter, Peter D., Levengood, Matthew R.
Published in Nature biotechnology (01.07.2019)
Published in Nature biotechnology (01.07.2019)
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Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates
Burke, Patrick J, Hamilton, Joseph Z, Jeffrey, Scott C, Hunter, Joshua H, Doronina, Svetlana O, Okeley, Nicole M, Miyamoto, Jamie B, Anderson, Martha E, Stone, Ivan J, Ulrich, Michelle L, Simmons, Jessica K, McKinney, Erica E, Senter, Peter D, Lyon, Robert P
Published in Molecular cancer therapeutics (01.01.2017)
Published in Molecular cancer therapeutics (01.01.2017)
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Development of orally active inhibitors of protein and cellular fucosylation
Okeley, Nicole M., Alley, Stephen C., Anderson, Martha E., Boursalian, Tamar E., Burke, Patrick J., Emmerton, Kim M., Jeffrey, Scott C., Klussman, Kerry, Law, Che-Leung, Sussman, Django, Toki, Brian E., Westendorf, Lori, Zeng, Weiping, Zhang, Xinqun, Benjamin, Dennis R., Senter, Peter D.
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (02.04.2013)
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Chemotherapy Delivery Issues in Central Nervous System Malignancy: A Reality Check
MULDOON, Leslie L, SOUSSAIN, Carole, NEUWELT, Edward A, JAHNKE, Kristoph, JOHANSON, Conrad, SIEGAL, Tali, SMITH, Quentin R, HALL, Walter A, HYNYNEN, Kullervo, SENTER, Peter D, PEEREBOOM, David M
Published in Journal of clinical oncology (01.06.2007)
Published in Journal of clinical oncology (01.06.2007)
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Journal Article
Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates
Neumann, Christopher S, Olivas, Kathleen C, Anderson, Martha E, Cochran, Julia H, Jin, Steven, Li, Fu, Loftus, Luke V, Meyer, David W, Neale, Jason, Nix, Jay C, Pittman, Paul G, Simmons, Jessica K, Ulrich, Michelle L, Waight, Andrew B, Wong, Abbie, Zaval, Margo C, Zeng, Weiping, Lyon, Robert P, Senter, Peter D
Published in Molecular cancer therapeutics (01.12.2018)
Published in Molecular cancer therapeutics (01.12.2018)
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Effects of Drug Loading on the Antitumor Activity of a Monoclonal Antibody Drug Conjugate
HAMBLETT, Kevin J, SENTER, Peter D, MEYER, Damon L, FRANCISCO, Joseph A, CHACE, Dana F, SUN, Michael M. C, LENOX, Joel, CERVENY, Charles G, KISSLER, Kim M, BERNHARDT, Starr X, KOPCHA, Anastasia K, ZABINSKI, Roger F
Published in Clinical cancer research (15.10.2004)
Published in Clinical cancer research (15.10.2004)
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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates
Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Setter, Jocelyn R, Hunter, Joshua H, Cochran, Julia H, Waight, Andrew B, Gordon, Kristine A, Toki, Brian E, Emmerton, Kim K, Zeng, Weiping, Stone, Ivan J, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Journal Article
The Pharmacologic Basis for Antibody-Auristatin Conjugate Activity
Alley, Stephen C, Zhang, Xinqun, Okeley, Nicole M, Anderson, Martha, Law, Che-Leung, Senter, Peter D, Benjamin, Dennis R
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2009)
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Journal Article
A previously undescribed tubulin binder
Field, Jessica J., Waight, Andrew B., Senter, Peter D.
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2014)
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Journal Article
Glucuronide-Linked Antibody-Tubulysin Conjugates Display Activity in MDR + and Heterogeneous Tumor Models
Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Lai, Holden W H, Leiske, Christopher I, Emmerton, Kim K, Waight, Andrew B, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
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Journal Article
Development of potent monoclonal antibody auristatin conjugates for cancer therapy
Senter, Peter D, Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L
Published in Nature biotechnology (01.07.2003)
Published in Nature biotechnology (01.07.2003)
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