Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) inhibitor elacridar
Chuan Tang, Seng, Nguyen, Luan N., Sparidans, Rolf W., Wagenaar, Els, Beijnen, Jos H., Schinkel, Alfred H.
Published in International journal of cancer (15.03.2014)
Published in International journal of cancer (15.03.2014)
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Super-Enhancers, Phase-Separated Condensates, and 3D Genome Organization in Cancer
Tang, Seng Chuan, Vijayakumar, Udhaya, Zhang, Ying, Fullwood, Melissa Jane
Published in Cancers (10.06.2022)
Published in Cancers (10.06.2022)
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The Endosomal Protein CEMIP Links WNT Signaling to MEK1-ERK1/2 Activation in Selumetinib-Resistant Intestinal Organoids
Duong, Hong Quan, Nemazanyy, Ivan, Rambow, Florian, Tang, Seng Chuan, Delaunay, Sylvain, Tharun, Lars, Florin, Alexandra, Büttner, Reinhard, Vandaele, Daniel, Close, Pierre, Marine, Jean-Christophe, Shostak, Kateryna, Chariot, Alain
Published in Cancer research (Chicago, Ill.) (15.08.2018)
Published in Cancer research (Chicago, Ill.) (15.08.2018)
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Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration
Tang, Seng Chuan, Lagas, Jurjen S., Lankheet, Nienke A.G., Poller, Birk, Hillebrand, Michel J., Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.
Published in International journal of cancer (01.01.2012)
Published in International journal of cancer (01.01.2012)
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Double-Transduced MDCKII Cells To Study Human P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) Interplay in Drug Transport across the Blood−Brain Barrier
Poller, Birk, Wagenaar, Els, Tang, Seng Chuan, Schinkel, Alfred H
Published in Molecular pharmaceutics (04.04.2011)
Published in Molecular pharmaceutics (04.04.2011)
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Impact of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) gene dosage on plasma pharmacokinetics and brain accumulation of dasatinib, sorafenib, and sunitinib
Tang, Seng Chuan, de Vries, Niels, Sparidans, Rolf W, Wagenaar, Els, Beijnen, Jos H, Schinkel, Alfred H
Published in The Journal of pharmacology and experimental therapeutics (01.09.2013)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2013)
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P-Glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain and Blood Disposition of the mTOR Inhibitor Everolimus (Afinitor) in Mice
SENG CHUAN TANG, SPARIDANS, Rolf W, KA LEI CHEUNG, FUKAMI, Tatsuki, DURMUS, Selvi, WAGENAAR, Els, YOKOI, Tsuyoshi, VAN VLIJMEN, Bart J. M, BEIJNEN, Jos H, SCHINKEL, Alfred H
Published in Clinical cancer research (15.06.2014)
Published in Clinical cancer research (15.06.2014)
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Liquid chromatography–tandem mass spectrometric assay for the ALK inhibitor crizotinib in mouse plasma
Sparidans, Rolf W., Tang, Seng Chuan, Nguyen, Luan N., Schinkel, Alfred H., Schellens, Jan H.M., Beijnen, Jos H.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.09.2012)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.09.2012)
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Elp3‐mediated codon‐dependent translation promotes mTORC2 activation and regulates macrophage polarization
Chen, Dawei, Nemazanyy, Ivan, Peulen, Olivier, Shostak, Kateryna, Xu, Xinyi, Tang, Seng Chuan, Wathieu, Caroline, Turchetto, Silvia, Tielens, Sylvia, Nguyen, Laurent, Close, Pierre, Desmet, Christophe, Klein, Sebastian, Florin, Alexandra, Büttner, Reinhard, Petrellis, Georgios, Dewals, Benjamin, Chariot, Alain
Published in The EMBO journal (15.09.2022)
Published in The EMBO journal (15.09.2022)
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Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth
Zhang, Ying, Chen, Kaijing, Tang, Seng Chuan, Cai, Yichao, Nambu, Akiko, See, Yi Xiang, Fu, Chaoyu, Raju, Anandhkumar, Lebeau, Benjamin, Ling, Zixun, Chan, Jia Jia, Tay, Yvonne, Mutwil, Marek, Lakshmanan, Manikandan, Tucker-Kellogg, Greg, Chng, Wee Joo, Tenen, Daniel G, Osato, Motomi, Tergaonkar, Vinay, Fullwood, Melissa Jane
Published in Nature structural & molecular biology (20.09.2024)
Published in Nature structural & molecular biology (20.09.2024)
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The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer
Tang, Seng Chuan, Lion, Quentin, Peulen, Olivier, Chariot, Philippe, Lavergne, Arnaud, Mayer, Alice, Fuster, Paula Allepuz, Close, Pierre, Klein, Sebastian, Florin, Alexandra, Büttner, Reinhard, Nemazanyy, Ivan, Shostak, Kateryna, Chariot, Alain
Published in Oncogene (05.01.2022)
Published in Oncogene (05.01.2022)
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P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict brain accumulation of the active sunitinib metabolite N-desethyl sunitinib
Tang, Seng Chuan, Lankheet, Nienke A G, Poller, Birk, Wagenaar, Els, Beijnen, Jos H, Schinkel, Alfred H
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2012)
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Genetically modified mouse models for oral drug absorption and disposition
Tang, Seng Chuan, Hendrikx, Jeroen JMA, Beijnen, Jos H, Schinkel, Alfred H
Published in Current opinion in pharmacology (01.12.2013)
Published in Current opinion in pharmacology (01.12.2013)
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P‑glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice
Tang, Seng Chuan, Kort, Anita, Cheung, Ka Lei, Rosing, Hilde, Fukami, Tatsuki, Durmus, Selvi, Wagenaar, Els, Hendrikx, Jeroen J. M. A, Nakajima, Miki, van Vlijmen, Bart J. M, Beijnen, Jos H, Schinkel, Alfred H
Published in Molecular pharmaceutics (05.10.2015)
Published in Molecular pharmaceutics (05.10.2015)
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Abstract 1518: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) limit sunitinib brain accumulation which can be enhanced by oral elacridar treatment
Tang, Seng Chuan, Lagas, Jurjen S., Lankheet, Nienke, Rosing, Hilde, Beijnen, Jos H., Schinkel, Alfred H.
Published in Cancer research (Chicago, Ill.) (15.04.2010)
Published in Cancer research (Chicago, Ill.) (15.04.2010)
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