The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Akinc, Akin, Maier, Martin A, Manoharan, Muthiah, Fitzgerald, Kevin, Jayaraman, Muthusamy, Barros, Scott, Ansell, Steven, Du, Xinyao, Hope, Michael J, Madden, Thomas D, Mui, Barbara L, Semple, Sean C, Tam, Ying K, Ciufolini, Marco, Witzigmann, Dominik, Kulkarni, Jayesh A, van der Meel, Roy, Cullis, Pieter R
Published in Nature nanotechnology (01.12.2019)
Published in Nature nanotechnology (01.12.2019)
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Journal Article
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based Therapeutics
Semple, Sean C, Leone, Robert, Barbosa, Christopher J, Tam, Ying K, Lin, Paulo J C
Published in Pharmaceutics (11.02.2022)
Published in Pharmaceutics (11.02.2022)
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Journal Article
Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system
Parhiz, Hamideh, Shuvaev, Vladimir V., Li, Qin, Papp, Tyler E., Akyianu, Awurama A., Shi, Ruiqi, Yadegari, Amir, Shahnawaz, Hamna, Semple, Sean C., Mui, Barbara L., Weissman, Drew, Muzykantov, Vladimir R., Glassman, Patrick M.
Published in Molecular therapy. Nucleic acids (11.06.2024)
Published in Molecular therapy. Nucleic acids (11.06.2024)
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Journal Article
Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid
Semple, Sean C, Harasym, Troy O, Clow, Kathy A, Ansell, Steven M, Klimuk, Sandra K, Hope, Michael J
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2005)
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Journal Article
Liposome-encapsulated vincristine, vinblastine and vinorelbine: A comparative study of drug loading and retention
Zhigaltsev, Igor V., Maurer, Norbert, Akhong, Quet-Fah, Leone, Robert, Leng, Esther, Wang, Jinfang, Semple, Sean C., Cullis, Pieter R.
Published in Journal of controlled release (05.05.2005)
Published in Journal of controlled release (05.05.2005)
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Journal Article
Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer
Leonetti, Carlo, Biroccio, Annamaria, D'Angelo, Carmen, Semple, Sean. C., Scarsella, Marco, Zupi, Gabriella
Published in The Prostate (15.09.2007)
Published in The Prostate (15.09.2007)
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Journal Article
Targeted Liposomal c-myc Antisense Oligodeoxynucleotides Induce Apoptosis and Inhibit Tumor Growth and Metastases in Human Melanoma Models
PASTORINO, Fabio, BRIGNOLE, Chiara, MARIMPIETRI, Danilo, PAGNAN, Gabriella, MORANDO, Adriana, RIBATTI, Domenico, SEMPLE, Sean C, GAMBINI, Claudio, ALLEN, Theresa M, PONZONI, Mirco
Published in Clinical cancer research (01.10.2003)
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Published in Clinical cancer research (01.10.2003)
Journal Article
Antitumor Efficacy of bcl-2 and c-myc Antisense Oligonucleotides in Combination with Cisplatin in Human Melanoma Xenografts: Relevance of the Administration Sequence
ZUPI, Gabriella, SCARSELLA, Marco, SEMPLE, Sean C, MOTTOLESE, Marcella, NATALI, Pier G, LEONETTI, Carlo
Published in Clinical cancer research (01.03.2005)
Published in Clinical cancer research (01.03.2005)
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Journal Article
Targeting the hepatitis B cccDNA with a sequence-specific ARCUS nuclease to eliminate hepatitis B virus in vivo
Gorsuch, Cassandra L., Nemec, Paige, Yu, Mei, Xu, Simin, Han, Dong, Smith, Jeff, Lape, Janel, van Buuren, Nicholas, Ramirez, Ricardo, Muench, Robert C., Holdorf, Meghan M., Feierbach, Becket, Falls, Greg, Holt, Jason, Shoop, Wendy, Sevigny, Emma, Karriker, Forrest, Brown, Robert V., Joshi, Amod, Goodwin, Tyler, Tam, Ying K., Lin, Paulo J.C., Semple, Sean C., Leatherbury, Neil, Delaney IV, William E., Jantz, Derek, Rhoden Smith, Amy
Published in Molecular therapy (07.09.2022)
Published in Molecular therapy (07.09.2022)
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Journal Article
Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin
Johnston, Michael J.W., Semple, Sean C., Klimuk, Sandy K., Ansell, Steve, Maurer, Norbert, Cullis, Pieter R.
Published in Biochimica et biophysica acta (01.05.2007)
Published in Biochimica et biophysica acta (01.05.2007)
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Journal Article
Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations
Johnston, Michael J.W., Semple, Sean C., Klimuk, Sandra K., Edwards, Katarina, Eisenhardt, Merete L., Leng, Esther C., Karlsson, Göran, Yanko, Daniel, Cullis, Pieter R.
Published in Biochimica et biophysica acta (2006)
Published in Biochimica et biophysica acta (2006)
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Journal Article
Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures
Semple, S C, Klimuk, S K, Harasym, T O, Dos Santos, N, Ansell, S M, Wong, K F, Maurer, N, Stark, H, Cullis, P R, Hope, M J, Scherrer, P
Published in Biochimica et biophysica acta (09.02.2001)
Published in Biochimica et biophysica acta (09.02.2001)
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Journal Article
Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity
Semple, Sean C., Leone, Robert, Wang, Jinfang, Leng, Esther C., Klimuk, Sandra K., Eisenhardt, Merete L., Yuan, Zuan-Ning, Edwards, Katarina, Maurer, Norbert, Hope, Michael J., Cullis, Pieter R., Ahkong, Quet-Fah
Published in Journal of pharmaceutical sciences (01.05.2005)
Published in Journal of pharmaceutical sciences (01.05.2005)
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Journal Article
Abstract 2829: Preclinical characterization of TKM-080301, a lipid nanoparticle formulation of a small interfering RNA directed against polo-like kinase 1
Semple, Sean C., Judge, Adam D., Robbins, Marjorie, Klimuk, Sandra, Eisenhardt, Merete, Crosley, Erin, Leung, Ada, Kwok, Raymond, Ambegia, Ellen, McClintock, Kevin, MacLachlan, Ian
Published in Cancer research (Chicago, Ill.) (15.04.2011)
Published in Cancer research (Chicago, Ill.) (15.04.2011)
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Journal Article
In vivo administration of liposomal vincristine sensitizes drug‐resistant human solid tumors
Leonetti, Carlo, Scarsella, Marco, Semple, Sean C., Molinari, Agnese, D'Angelo, Carmen, Stoppacciaro, Antonella, Biroccio, Annamaria, Zupi, Gabriella
Published in International journal of cancer (10.07.2004)
Published in International journal of cancer (10.07.2004)
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