In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia
Barrow, JC, Nantermet, PG, Selnick, HG, Glass, KL, Rittle, KE, Gilbert, KF, Steele, TG, Homnick, CF, Freidinger, RM, Ransom, RW, Kling, P, Reiss, D, Broten, TP, Schorn, TW, Chang, RSL, O'Malley, SS, Olah, TV, Ellis, JD, Barrish, A, Kassahun, K, Leppert, P, Nagarathnam, D, Forray, C
Published in Journal of medicinal chemistry (13.07.2000)
Published in Journal of medicinal chemistry (13.07.2000)
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Journal Article
Discovery and evaluation of potent P-1 aryl heterocycle-based thrombin inhibitors
Young, MB, Barrow, JC, Glass, KL, Lundell, GF, Newton, CL, Pellicore, JM, Rittle, KE, Selnick, HG, Stauffer, KJ, Vacca, JP, Williams, PD, Bohn, D, Clayton, FC, Cook, JJ, Krueger, JA, Kuo, LC, Lewis, SD, Lucas, BJ, McMasters, DR, Miller-Stein, C, Pietrak, BL, Wallace, AA, White, RB, Wong, B, Yan, YW, Nantermet, PG
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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Journal Article
Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase
Liverton, Nigel J, Butcher, John W, Claiborne, Christopher F, Claremon, David A, Libby, Brian E, Nguyen, Kevin T, Pitzenberger, Steven M, Selnick, Harold G, Smith, Garry R, Tebben, Andrew, Vacca, Joseph P, Varga, Sandor L, Agarwal, Lily, Dancheck, Kim, Forsyth, Amy J, Fletcher, Daniel S, Frantz, Betsy, Hanlon, William A, Harper, Coral F, Hofsess, Scott J, Kostura, Matthew, Lin, Jiunn, Luell, Sylvie, O'Neill, Edward A, Orevillo, Chad J, Pang, Margaret, Parsons, Janey, Rolando, Anna, Sahly, Yousif, Visco, Denise M, O'Keefe, Stephen J
Published in Journal of medicinal chemistry (17.06.1999)
Published in Journal of medicinal chemistry (17.06.1999)
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Journal Article
9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors
Stauffer, Kenneth J, Williams, Peter D, Selnick, Harold G, Nantermet, Philippe G, Newton, Christina L, Homnick, Carl F, Zrada, Matthew M, Lewis, S. Dale, Lucas, Bobby J, Krueger, Julie A, Pietrak, Beth L, Lyle, Elizabeth A, Singh, Rominder, Miller-Stein, Cynthia, White, Rebecca B, Wong, Bradley, Wallace, Audrey A, Sitko, Gary R, Cook, Jacquelyn J, Holahan, Marie A, Stranieri-Michener, Maria, Leonard, Yvonne M, Lynch, Joseph J, McMasters, Daniel R, Yan, Youwei
Published in Journal of medicinal chemistry (07.04.2005)
Published in Journal of medicinal chemistry (07.04.2005)
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Journal Article
Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics
Barrow, James C, Nantermet, Philippe G, Stauffer, Shaun R, Ngo, Phung L, Steinbeiser, Melissa A, Mao, Shi-Shan, Carroll, Steven S, Bailey, Carolyn, Colussi, Dennis, Bosserman, Michelle, Burlein, Christine, Cook, Jacquelynn J, Sitko, Gary, Tiller, Philip R, Miller-Stein, Cynthia M, Rose, Mark, McMasters, Daniel R, Vacca, Joseph P, Selnick, Harold G
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Journal Article
P 2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
Nantermet, Philippe G., Burgey, Christopher S., Robinson, Kyle A., Pellicore, Janetta M., Newton, Christina L., Deng, James Z., Selnick, Harold G., Lewis, S. Dale, Lucas, Bobby J., Krueger, Julie A., Miller-Stein, Cynthia, White, Rebecca B., Wong, Bradley, McMasters, Daniel R., Wallace, Audrey A., Lynch, Joseph J., Yan, Youwei, Chen, Zhongguo, Kuo, Lawrence, Gardell, Stephen J., Shafer, Jules A., Vacca, Joseph P., Lyle, Terry A.
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by (R)-2-(2,4- Trifluoromethyl)-N-[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1H-benzo[e][1,4]diazepin-3-yl]acetamide
Selnick, Harold G, Liverton, Nigel J, Baldwin, John J, Butcher, John W, Claremon, David A, Elliott, Jason M, Freidinger, Roger M, King, Stella A, Libby, Brian E, McIntyre, Charles J, Pribush, David A, Remy, David C, Smith, Garry R, Tebben, Andrew J, Jurkiewicz, Nancy K, Lynch, Joseph J, Salata, Joseph J, Sanguinetti, Michael C, Siegl, Peter K. S, Slaughter, Donald E, Vyas, Kamlesh
Published in Journal of medicinal chemistry (21.11.1997)
Published in Journal of medicinal chemistry (21.11.1997)
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Journal Article
Unexpected enhancement of thrombin inhibitor potency with o-aminoalkylbenzylamides in the P1 position
RITTLE, Kenneth E, BARROW, James C, NANTERMET, Philippe G, NEWTON, Christina L, SANDERS, William M, YOUWEI YAN, VACCA, Joseph P, SELNICK, Harold G, CUTRONA, Kellie J, GLASS, Kristen L, KRUEGER, Julie A, KUO, Lawrence C, LEWIS, S. Dale, LUCAS, Bobby J, MCMASTERS, Daniel R, MORRISSETTE, Matthew M
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
Published in Bioorganic & medicinal chemistry letters (20.10.2003)
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Journal Article
Design and synthesis of potent and selective macrocyclic thrombin inhibitors
Nantermet, Philippe G., Barrow, James C., Newton, Christina L., Pellicore, Janetta M., Young, MaryBeth, Lewis, S.Dale, Lucas, Bobby J., Krueger, Julie A., McMasters, Daniel R., Yan, Youwei, Kuo, Lawrence C., Vacca, Joseph P., Selnick, Harold G.
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
Published in Bioorganic & medicinal chemistry letters (18.08.2003)
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Journal Article
Discovery of a nonpeptidic small molecule antagonist of the human platelet thrombin receptor (PAR-1)
Nantermet, Philippe G, Barrow, James C, Lundell, George F, Pellicore, Janetta M, Rittle, Kenneth E, Young, MaryBeth, Freidinger, Roger M, Connolly, Thomas M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Gould, Robert J, Prendergast, Kris, Selnick, Harold G
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
Published in Bioorganic & medicinal chemistry letters (11.02.2002)
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Journal Article
Antiarrhythmic Efficacy of Selective Blockade of the Cardiac Slowly Activating Delayed Rectifier Current, I Ks , in Canine Models of Malignant Ischemic Ventricular Arrhythmia
Lynch, Joseph J., Houle, Melanie S., Stump, Gary L., Wallace, Audrey A., Gilberto, David B., Jahansouz, Hossain, Smith, Garry R., Tebben, Andrew J., Liverton, Nigel J., Selnick, Harold G., Claremon, David A., Billman, George E.
Published in Circulation (New York, N.Y.) (02.11.1999)
Published in Circulation (New York, N.Y.) (02.11.1999)
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Journal Article
Antiarrhythmic Efficacy of Combined I Ks and β-Adrenergic Receptor Blockade
Lynch, Joseph J., Salata, Joseph J., Wallace, Audrey A., Stump, Gary L., Gilberto, David B., Jahansouz, Hossain, Liverton, Nigel J., Selnick, Harold G., Claremon, David A.
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2002)
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Journal Article
Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists
Barrow, James C, Nantermet, Philippe G, Selnick, Harold G, Glass, Kristen L, Ngo, Phung L, Young, Mary Beth, Pellicore, Janetta M, Breslin, Michael J, Hutchinson, John H, Freidinger, Roger M, Condra, Cindra, Karczewski, Jerzy, Bednar, Rodney A, Gaul, Stanley L, Stern, Andrew, Gould, Robert, Connolly, Thomas M
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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Journal Article
The total synthesis of avermectin A1a
Danishefsky, Samuel J, Armistead, David M, Wincott, Francine E, Selnick, Harold G, Hungate, Randall
Published in Journal of the American Chemical Society (01.04.1989)
Published in Journal of the American Chemical Society (01.04.1989)
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Journal Article
Total synthesis of zincophorin
Danishefsky, Samuel J, Selnick, Harold G, Zelle, Robert E, DeNinno, Michael P
Published in Journal of the American Chemical Society (01.06.1988)
Published in Journal of the American Chemical Society (01.06.1988)
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Journal Article
Bis-heteroannulation. 16. A synthetic approach to geigerin
Jacobi, Peter A., Touchette, Kim M., Selnick, Harold G.
Published in Journal of organic chemistry (01.11.1992)
Published in Journal of organic chemistry (01.11.1992)
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