Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
Tichenor, Mark S, Wiener, John J. M, Rao, Navin L, Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D, Bacani, Genesis M, Wei, Jianmei, Chang, Leon, Murrey, Heather E, Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J, Wu, JieJun, Seierstad, Mark, Bembenek, Scott D, Leonard, Kristi A, Lebsack, Alec D, Venable, Jennifer D, Edwards, James P
Published in ACS medicinal chemistry letters (13.05.2021)
Published in ACS medicinal chemistry letters (13.05.2021)
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Library Enhancement through the Wisdom of Crowds
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Published in Journal of chemical information and modeling (27.12.2011)
Published in Journal of chemical information and modeling (27.12.2011)
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Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase
Keith, John M., Apodaca, Richard, Xiao, Wei, Seierstad, Mark, Pattabiraman, Kanaka, Wu, Jiejun, Webb, Michael, Karbarz, Mark J., Brown, Sean, Wilson, Sandy, Scott, Brian, Tham, Chui-Se, Luo, Lin, Palmer, James, Wennerholm, Michelle, Chaplan, Sandra, Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry (01.09.2008)
Published in Bioorganic & medicinal chemistry (01.09.2008)
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Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8
Ravula, Suchitra, Savall, Brad M, Wu, Nyantsz, Lord, Brian, Coe, Kevin, Wang, Kai, Seierstad, Mark, Swanson, Devin M, Ziff, Jeannie, Nguyen, Minh, Leung, Perry, Rynberg, Ray, La, David, Pippel, Daniel J, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors
Keith, John M., Tichenor, Mark S., Apodaca, Richard L., Xiao, Wei, Jones, William M., Seierstad, Mark, Pierce, Joan M., Palmer, James A., Webb, Michael, Karbarz, Mark J., Scott, Brian P., Wilson, Sandy J., Wennerholm, Michelle L., Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
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Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase
Keith, John M., Jones, William M., Pierce, Joan M., Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle L., Chang, Leon, Brown, Sean M., Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
Published in Bioorganic & medicinal chemistry letters (01.02.2014)
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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites
Tichenor, Mark S., Keith, John M., Jones, William M., Pierce, Joan M., Merit, Jeff, Hawryluk, Natalie, Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Wilson, Sandy J., Wennerholm, Michelle L., Woestenborghs, Filip, Beerens, Dominiek, Luo, Lin, Brown, Sean M., Boeck, Marlies De, Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase
Keith, John M., Hawryluk, Natalie, Apodaca, Richard L., Chambers, Allison, Pierce, Joan M., Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark J., Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle L., Chang, Leon, Rizzolio, Michele, Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
Published in Bioorganic & medicinal chemistry letters (01.03.2014)
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Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate
Keith, John M, Apodaca, Rich, Tichenor, Mark, Xiao, Wei, Jones, William, Pierce, Joan, Seierstad, Mark, Palmer, James, Webb, Michael, Karbarz, Mark, Scott, Brian, Wilson, Sandy, Luo, Lin, Wennerholm, Michelle, Chang, Leon, Brown, Sean, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra, Breitenbucher, J. Guy
Published in ACS medicinal chemistry letters (11.10.2012)
Published in ACS medicinal chemistry letters (11.10.2012)
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LEONARD KRISTI, KREUTTER KEVIN D, CHAI WENYING, SEIERSTAD MARK, BACANI GENESIS M, KOUDRIAKOVA TATIANA, TICHENOR MARK S, VENABLE JENNIFER D, RIZZOLIO MICHELE C, SMITH RUSSEL C, KRAWCZUK PAUL J, WANG AIHUA
Year of Publication 07.08.2019
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Year of Publication 07.08.2019
Patent
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)
Timmons, Amy, Seierstad, Mark, Apodaca, Rich, Epperson, Matt, Pippel, Dan, Brown, Sean, Chang, Leon, Scott, Brian, Webb, Michael, Chaplan, Sandra R., Breitenbucher, J. Guy
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Dual serotonin transporter/histamine H 3 ligands: Optimization of the H 3 pharmacophore
Keith, John M., Gomez, Leslie A., Letavic, Michael A., Ly, Kiev S., Jablonowski, Jill A., Seierstad, Mark, Barbier, Ann J., Wilson, Sandy J., Boggs, Jamin D., Fraser, Ian C., Mazur, Curt, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structureamutagenicity relationships for arylamine metabolites
Tichenor, Mark S, Keith, John M, Jones, William M, Pierce, Joan M, Merit, Jeff, Hawryluk, Natalie, Seierstad, Mark, Palmer, James A, Webb, Michael, Karbarz, Mark J, Wilson, Sandy J, Wennerholm, Michelle L, Woestenborghs, Filip, Beerens, Dominiek, Luo, Lin, Brown, Sean M, Boeck, Marlies De, Chaplan, Sandra R, Breitenbucher, JGuy
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
Published in Bioorganic & medicinal chemistry letters (15.12.2012)
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The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y sub(2) receptor
Swanson, Devin M, Wong, Victoria D, Jablonowski, Jill A, Shah, Chandra, Rudolph, Dale A, Dvorak, Curt A, Seierstad, Mark, Dvorak, Lisa K, Morton, Kirsten, Nepomuceno, Diane, Atack, John R, Bonaventure, Pascal, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Design Optimization of 1,3-Diphospha-2,4-diboretane Diradicals
Seierstad, Mark, Kinsinger, Christopher R., Cramer, Christopher J.
Published in Angewandte Chemie International Edition (18.10.2002)
Published in Angewandte Chemie International Edition (18.10.2002)
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The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y2 receptor
Swanson, Devin M., Wong, Victoria D., Jablonowski, Jill A., Shah, Chandra, Rudolph, Dale A., Dvorak, Curt A., Seierstad, Mark, Dvorak, Lisa K., Morton, Kirsten, Nepomuceno, Diane, Atack, John R., Bonaventure, Pascal, Lovenberg, Timothy W., Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Dual serotonin transporter/histamine H sub(3) ligands: Optimization of the H sub(3) pharmacophore
Keith, John M, Gomez, Leslie A, Letavic, Michael A, Ly, Kiev S, Jablonowski, Jill A, Seierstad, Mark, Barbier, Ann J, Wilson, Sandy J, Boggs, Jamin D, Fraser, Ian C, Mazur, Curt, Lovenberg, Timothy W, Carruthers, Nicholas I
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
Published in Bioorganic & medicinal chemistry letters (01.02.2007)
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