Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart
Published in Molecular therapy (07.03.2018)
Published in Molecular therapy (07.03.2018)
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The Polyploid State Plays a Tumor-Suppressive Role in the Liver
Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H., Zhang, Yu, Gopal, Purva, Tarlow, Branden D., Siegwart, Daniel J., Zhu, Hao
Published in Developmental cell (26.02.2018)
Published in Developmental cell (26.02.2018)
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Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid‐like nanoparticles resolves liver fibrosis
Jiménez Calvente, Carolina, Sehgal, Alfica, Popov, Yury, Kim, Yong Ook, Zevallos, Victor, Sahin, Ugur, Diken, Mustafa, Schuppan, Detlef
Published in Hepatology (Baltimore, Md.) (01.10.2015)
Published in Hepatology (Baltimore, Md.) (01.10.2015)
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Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc-siRNA conjugates
Nair, Jayaprakash K, Attarwala, Husain, Sehgal, Alfica, Wang, Qianfan, Aluri, Krishna, Zhang, Xuemei, Gao, Minggeng, Liu, Ju, Indrakanti, Ramesh, Schofield, Sally, Kretschmer, Philip, Brown, Christopher R, Gupta, Swati, Willoughby, Jennifer L S, Boshar, Julie A, Jadhav, Vasant, Charisse, Klaus, Zimmermann, Tracy, Fitzgerald, Kevin, Manoharan, Muthiah, Rajeev, Kallanthottathil G, Akinc, Akin, Hutabarat, Renta, Maier, Martin A
Published in Nucleic acids research (02.11.2017)
Published in Nucleic acids research (02.11.2017)
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Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
Coelho, Teresa, Adams, David, Silva, Ana, Lozeron, Pierre, Hawkins, Philip N, Mant, Timothy, Perez, Javier, Chiesa, Joseph, Warrington, Steve, Tranter, Elizabeth, Munisamy, Malathy, Falzone, Rick, Harrop, Jamie, Cehelsky, Jeffrey, Bettencourt, Brian R, Geissler, Mary, Butler, James S, Sehgal, Alfica, Meyers, Rachel E, Chen, Qingmin, Borland, Todd, Hutabarat, Renta M, Clausen, Valerie A, Alvarez, Rene, Fitzgerald, Kevin, Gamba-Vitalo, Christina, Nochur, Saraswathy V, Vaishnaw, Akshay K, Sah, Dinah W.Y, Gollob, Jared A, Suhr, Ole B
Published in The New England journal of medicine (29.08.2013)
Published in The New England journal of medicine (29.08.2013)
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Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration
Zhang, Shuyuan, Nguyen, Liem H., Zhou, Kejin, Tu, Ho-Chou, Sehgal, Alfica, Nassour, Ibrahim, Li, Lin, Gopal, Purva, Goodman, Joshua, Singal, Amit G., Yopp, Adam, Zhang, Yu, Siegwart, Daniel J., Zhu, Hao
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2018)
Published in Gastroenterology (New York, N.Y. 1943) (01.04.2018)
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The Polyploid State Plays a Tumor-Suppressive Role in the Liver
Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H, Zhang, Yu, Gopal, Purva, Tarlow, Branden D, Siegwart, Daniel J, Zhu, Hao
Published in Developmental cell (05.11.2018)
Published in Developmental cell (05.11.2018)
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Opportunities and challenges for innovative and equitable healthcare
Ecker, David J., Aiello, Clarice D., Arron, Joseph R., Bennett, C. Frank, Bernard, Amy, Breakefield, Xandra O., Broderick, Timothy J., Callier, Shawneequa L., Canton, Barry, Chen, Janice S., Fishburn, C. Simone, Garrett, Banning, Hecht, Sidney M., Janowitz, Tobias, Kliegman, Melinda, Krainer, Adrian, Louis, Chrystal U., Lowe, Christopher, Sehgal, Alfica, Tozan, Yesim, Tracey, Kevin J., Urnov, Fyodor, Wattendorf, Daniel, Williams, Thomas W., Zhao, Xuanhe, Hayden, Michael R.
Published in Nature reviews. Drug discovery (01.05.2024)
Published in Nature reviews. Drug discovery (01.05.2024)
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Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration
Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau, Robert T., Liu, Yuting, Bumcrot, David
Published in Scientific reports (25.01.2024)
Published in Scientific reports (25.01.2024)
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Author Correction: Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration
Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau, Robert T., Liu, Yuting, Bumcrot, David
Published in Scientific reports (23.04.2024)
Published in Scientific reports (23.04.2024)
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Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification
Chan, Amy, Liebow, Abigail, Yasuda, Makiko, Gan, Lin, Racie, Tim, Maier, Martin, Kuchimanchi, Satya, Foster, Don, Milstein, Stuart, Charisse, Klaus, Sehgal, Alfica, Manoharan, Muthiah, Meyers, Rachel, Fitzgerald, Kevin, Simon, Amy, Desnick, Robert J, Querbes, William
Published in Molecular therapy. Nucleic acids (2015)
Published in Molecular therapy. Nucleic acids (2015)
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A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development
Severgnini, Mariano, Sherman, Jennifer, Sehgal, Alfica, Jayaprakash, Narayanannair K., Aubin, Justin, Wang, Gang, Zhang, Ligang, Peng, Chang G., Yucius, Kristina, Butler, Jim, Fitzgerald, Kevin
Published in Cytotechnology (Dordrecht) (01.03.2012)
Published in Cytotechnology (Dordrecht) (01.03.2012)
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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
Lee, Hyukjin, Lytton-Jean, Abigail K. R., Chen, Yi, Love, Kevin T., Park, Angela I., Karagiannis, Emmanouil D., Sehgal, Alfica, Querbes, William, Zurenko, Christopher S., Jayaraman, Muthusamy, Peng, Chang G., Charisse, Klaus, Borodovsky, Anna, Manoharan, Muthiah, Donahoe, Jessica S., Truelove, Jessica, Nahrendorf, Matthias, Langer, Robert, Anderson, Daniel G.
Published in Nature nanotechnology (03.06.2012)
Published in Nature nanotechnology (03.06.2012)
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Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings
Schwartz, Brian E., Rajagopal, Vaishnavi, Smith, Cynthia, Cohick, Evan, Whissell, Gavin, Gamboa, Mario, Pai, Rutuja, Sigova, Alla, Grossman, Iris, Bumcrot, David, Sasidharan, Kavitha, Romeo, Stefano, Sehgal, Alfica, Pingitore, Piero
Published in Cells (Basel, Switzerland) (07.10.2020)
Published in Cells (Basel, Switzerland) (07.10.2020)
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The roles of individual mammalian argonautes in RNA interference in vivo
Ruda, Vera M, Chandwani, Rohit, Sehgal, Alfica, Bogorad, Roman L, Akinc, Akin, Charisse, Klaus, Tarakhovsky, Alexander, Novobrantseva, Tatiana I, Koteliansky, Victor
Published in PloS one (03.07.2014)
Published in PloS one (03.07.2014)
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Tissue-specific gene silencing monitored in circulating RNA
Sehgal, Alfica, Chen, Qingmin, Gibbings, Derrick, Sah, Dinah W Y, Bumcrot, David
Published in RNA (Cambridge) (01.02.2014)
Published in RNA (Cambridge) (01.02.2014)
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Novel roles for ATP-binding cassette G transporters in lipid redistribution in Toxoplasma
Ehrenman, Karen, Sehgal, Alfica, Lige, Bao, Stedman, Timothy T, Joiner, Keith A, Coppens, Isabelle
Published in Molecular microbiology (01.06.2010)
Published in Molecular microbiology (01.06.2010)
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The P Domain of the P0 Protein of Plasmodium falciparum Protects against Challenge with Malaria Parasites
Rajeshwari, K, Patel, Kalpesh, Nambeesan, Savithri, Mehta, Monika, Sehgal, Alfica, Chakraborty, Tirtha, Sharma, Shobhona
Published in Infection and Immunity (01.09.2004)
Published in Infection and Immunity (01.09.2004)
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Journal Article
Specific hepatic delivery of procollagen [alpha]1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis
Jimenez Calvente, Carolina, Sehgal, Alfica, Popov, Yury, Kim, Yong Ook, Zevallos, Victor, Sahin, Ugur, Diken, Mustafa, Schuppan, Detlef
Published in Hepatology (Baltimore, Md.) (01.10.2015)
Published in Hepatology (Baltimore, Md.) (01.10.2015)
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