Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining
Hsiao, Yi-Chun, Wallweber, Heidi Ackerly, Alberstein, Robert G., Lin, Zhonghua, Du, Changchun, Etxeberria, Ainhoa, Aung, Theint, Shang, Yonglei, Seshasayee, Dhaya, Seeger, Franziska, Watkins, Andrew M., Hansen, David V., Bohlen, Christopher J., Hsu, Peter L., Hötzel, Isidro
Published in Nature communications (27.09.2024)
Published in Nature communications (27.09.2024)
Get full text
Journal Article
Designed proteins assemble antibodies into modular nanocages
Divine, Robby, Dang, Ha V, Ueda, George, Fallas, Jorge A, Vulovic, Ivan, Sheffler, William, Saini, Shally, Zhao, Yan Ting, Raj, Infencia Xavier, Morawski, Peter A, Jennewein, Madeleine F, Homad, Leah J, Wan, Yu-Hsin, Tooley, Marti R, Seeger, Franziska, Etemadi, Ali, Fahning, Mitchell L, Lazarovits, James, Roederer, Alex, Walls, Alexandra C, Stewart, Lance, Mazloomi, Mohammadali, King, Neil P, Campbell, Daniel J, McGuire, Andrew T, Stamatatos, Leonidas, Ruohola-Baker, Hannele, Mathieu, Julie, Veesler, David, Baker, David
Published in Science (American Association for the Advancement of Science) (02.04.2021)
Published in Science (American Association for the Advancement of Science) (02.04.2021)
Get full text
Journal Article
Su1733 ORAL IL-23R ANTAGONIST MINIPROTEIN MB1 IS AS EFFECTIVE AS GUSELKUMAB IN A PRECLINICAL MODEL OF COLITIS
Berger, Stephanie, Seeger, Franziska, Yu, Ta-Yi, Aydin, Merve, Glassman, Caleb, Arguinchona, Lauren, Sniezek, Catherine, Blackstone, Alyssa, Carter, Lauren, Ravichandran, Rashmi, Ahlrichs, Maggie, Murphy, Michael P., Pultz, Ingrid S., Kang, Alex, Bera, Asim, Stewart, Lance, Garcia, K. Christopher, Beigel, Florian, Siebeck, Matthias, Gropp, Roswitha, Baker, David
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Published in Gastroenterology (New York, N.Y. 1943) (18.05.2024)
Get full text
Journal Article
Preclinical proof of principle for orally delivered Th17 antagonist miniproteins
Berger, Stephanie, Seeger, Franziska, Yu, Ta-Yi, Aydin, Merve, Yang, Huilin, Rosenblum, Daniel, Guenin-Macé, Laure, Glassman, Caleb, Arguinchona, Lauren, Sniezek, Catherine, Blackstone, Alyssa, Carter, Lauren, Ravichandran, Rashmi, Ahlrichs, Maggie, Murphy, Michael, Pultz, Ingrid Swanson, Kang, Alex, Bera, Asim K., Stewart, Lance, Garcia, K. Christopher, Naik, Shruti, Spangler, Jamie B., Beigel, Florian, Siebeck, Matthias, Gropp, Roswitha, Baker, David
Published in Cell (08.08.2024)
Published in Cell (08.08.2024)
Get full text
Journal Article
Interfacial Residues Promote an Optimal Alignment of the Catalytic Center in Human Soluble Guanylate Cyclase: Heterodimerization Is Required but Not Sufficient for Activity
Seeger, Franziska, Quintyn, Royston, Tanimoto, Akiko, Williams, Gareth J, Tainer, John A, Wysocki, Vicki H, Garcin, Elsa D
Published in Biochemistry (Easton) (08.04.2014)
Published in Biochemistry (Easton) (08.04.2014)
Get full text
Journal Article
Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation
Sarkar, Anindya, Dai, Yue, Haque, Mohammad Mahfuzul, Seeger, Franziska, Ghosh, Arnab, Garcin, Elsa D, Montfort, William R, Hazen, Stanley L, Misra, Saurav, Stuehr, Dennis J
Published in The Journal of biological chemistry (28.08.2015)
Published in The Journal of biological chemistry (28.08.2015)
Get full text
Journal Article
Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase
Sarkar, Anindya, Dai, Yue, Haque, Mohammad Mahfuzul, Seeger, Franziska, Ghosh, Arnab, Garcin, Elsa D., Montfort, William R., Hazen, Stanley L., Misra, Saurav, Stuehr, Dennis J.
Published in The Journal of biological chemistry (28.08.2015)
Published in The Journal of biological chemistry (28.08.2015)
Get full text
Journal Article
Oral 2012-1 - Interfacial residues promote an optimal alignment of the catalytic center in soluble guanylate cyclase
Garcin, Elsa, Seeger, Franziska, Quintyn, Royston, Tanimoto, Akiko, Williams, Gareth, Tainer, John, Wysocki, Vicki
Published in Nitric oxide (15.11.2014)
Published in Nitric oxide (15.11.2014)
Get full text
Journal Article