Design of HIV Protease Inhibitors Based on Inorganic Polyhedral Metallacarboranes
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Published in Journal of medicinal chemistry (26.11.2009)
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Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells
Pola, Robert, Král, Vlastimil, Filippov, Sergey K, Kaberov, Leonid, Etrych, Tomáš, Sieglová, Irena, Sedláček, Juraj, Fábry, Milan, Pechar, Michal
Published in Biomacromolecules (14.01.2019)
Published in Biomacromolecules (14.01.2019)
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From Nonpeptide toward Noncarbon Protease Inhibitors: Metallacarboranes as Specific and Potent Inhibitors of HIV Protease
Petr Cígler, Milan Kožíšek, Pavlína Řezáčová, Jíří Brynda, Otwinowski, Zbyszek, Jana Pokorná, Jaromír Plešek, Bohumír Grüner, Lucie Dolečková-Marešová, Martin Máša, Juraj Sedláček, Jochen Bodem, Kräusslich, Hans-Georg, Král, Vladimír, Jan Konvalinka
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Published in Proceedings of the National Academy of Sciences - PNAS (25.10.2005)
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Hydroxyethylamine Isostere of an HIV-1 Protease Inhibitor Prefers Its Amine to the Hydroxy Group in Binding to Catalytic Aspartates. A Synchrotron Study of HIV-1 Protease in Complex with a Peptidomimetic Inhibitor
Dohnálek, Jan, Hašek, Jindřich, Dušková, Jarmila, Petroková, Hana, Hradilek, Martin, Souček, Milan, Konvalinka, Jan, Brynda, Jiří, Sedláček, Juraj, Fábry, Milan
Published in Journal of medicinal chemistry (28.03.2002)
Published in Journal of medicinal chemistry (28.03.2002)
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Three-dimensional structure of an fab-peptide complex: structural basis of HIV-1 protease inhibition by a monoclonal antibody
Lescar, Julien, Stouracova, Renata, Riottot, Marie-Madeleine, Chitarra, Véronique, Brynda, Jiri, Fabry, Milan, Horejsi, Magda, Sedlacek, Juraj, Bentley, Graham A
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Published in Journal of molecular biology (18.04.1997)
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Stabilization of antibody structure upon association to a human carbonic anhydrase IX epitope studied by X-ray crystallography, microcalorimetry, and molecular dynamics simulations
Král, Vlastimil, Mader, Pavel, Collard, Renata, Fábry, Milan, Hořejší, Magdaléna, Řezáčová, Pavlína, Kožíšek, Milan, Závada, Jan, Sedláček, Juraj, Rulíšek, Lubomír, Brynda, Jiří
Published in Proteins, structure, function, and bioinformatics (15.05.2008)
Published in Proteins, structure, function, and bioinformatics (15.05.2008)
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Potent inhibition of drug-resistant HIV protease variants by monoclonal antibodies
Bartoňová, Vanda, Král, Vlastimil, Sieglová, Irena, Brynda, Jiří, Fábry, Milan, Hořejší, Magdalena, Kožíšek, Milan, Šašková, Klára Grantz, Konvalinka, Jan, Sedláček, Juraj, Řezáčová, Pavlína
Published in Antiviral research (01.06.2008)
Published in Antiviral research (01.06.2008)
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Recombinant fragment of an antibody tailored for direct radioiodination
Sedláček, Juraj, Fábry, Milan, Sieglová, Irena, Král, Vlastimil, Uhnáková, Bronislava, Múdra, Marcela, Kronrád, Leo, Sawicka, Agnieszka, Mikolajczak, Renata, Řezáčová, Pavlína
Published in Journal of labelled compounds & radiopharmaceuticals (01.01.2012)
Published in Journal of labelled compounds & radiopharmaceuticals (01.01.2012)
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Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV‐1 protease inhibitors
Petroková, Hana, Dušková, Jarmila, Dohnálek, Jan, Skálová, Tereza, Vondráčková‐Buchtelová, Eva, Souček, Milan, Konvalinka, Jan, Brynda, Jiří, Fábry, Milan, Sedláček, Juraj, Hašek, Jindřich
Published in European journal of biochemistry (01.11.2004)
Published in European journal of biochemistry (01.11.2004)
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Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex
Brynda, Jiří, Řezáčová, Pavlína, Fábry, Milan, Hořejší, Magdalena, Štouračová, Renata, Souček, Milan, Hradílek, Martin, Konvalinka, Jan, Sedláček, Juraj
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2004)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2004)
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Regular arrangement of periodates bound to lysozyme
Ondráček, Jan, Weiss, Manfred S., Brynda, Jiří, Fiala, Jaroslav, Jursík, František, Řezáčová, Pavlína, Jenner, Lasse B., Sedláček, Juraj
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2005)
Published in Acta crystallographica. Section D, Biological crystallography. (01.09.2005)
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A Phenylnorstatine Inhibitor Binding to HIV-1 Protease: Geometry, Protonation, and Subsite−Pocket Interactions Analyzed at Atomic Resolution
Brynda, Jiri, Rezacova, Pavlina, Fabry, Milan, Horejsi, Magdalena, Stouracova, Renata, Sedlacek, Juraj, Soucek, Milan, Hradilek, Martin, Lepsik, Martin, Konvalinka, Jan
Published in Journal of medicinal chemistry (08.04.2004)
Published in Journal of medicinal chemistry (08.04.2004)
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On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 Å resolution
Dušková, Jarmila, Dohnálek, Jan, Skálová, Tereza, Petroková, Hana, Vondráčková, Eva, Hradílek, Martin, Konvalinka, Jan, Souček, Milan, Brynda, Jiří, Fábry, Milan, Sedláček, Juraj, Hašek, Jindřich
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
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Crystal structure of a cross-reaction complex between an anti-HIV-1 protease antibody and an HIV-2 protease peptide
Rezacova, Pavlina, Brynda, Jiri, Lescar, Julien, Fabry, Milan, Horejsi, Magda, Sieglova, Irena, Sedlacek, Juraj, Bentley, Graham A.
Published in Journal of structural biology (01.03.2005)
Published in Journal of structural biology (01.03.2005)
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Structural Basis of HIV-1 and HIV-2 Protease Inhibition by a Monoclonal Antibody
Rezacova, Pavlina, Lescar, Julien, Brynda, Jiri, Fabry, Milan, Horejsi, Magda, Sedlacek, Juraj, Bentley, Graham A.
Published in Structure (London) (01.10.2001)
Published in Structure (London) (01.10.2001)
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Structure of a single-chain Fv fragment of an antibody that inhibits the HIV-1 and HIV-2 proteases
Lescar, Julien, Brynda, Jiri, Fabry, Milan, Horejsi, Magda, Rezacova, Pavlina, Sedlacek, Juraj, Bentley, Graham A.
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2003)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2003)
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Link between a novel human [gamma]D-crystallin allele and a unique cataract phenotype explained by protein crystallography
Kmoch, Stanislav, Brynda, Jiri, Befekadu Asfaw, Bezouka, Karel, Novak, Petr, Rezacova, Pavlina, Ondrova, Lenka, Filipec, Martin, Sedlacek, Juraj, Elleder, Milan
Published in Human molecular genetics (22.07.2000)
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Published in Human molecular genetics (22.07.2000)
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Configurations of Diastereomeric Hydroxyethylene Isosteres Strongly Affect Biological Activities of a Series of Specific Inhibitors of Human‐Immunodeficiency‐Virus Proteinase
Konvalinka, Jan, Litera, Jaroslav, Weber, Jan, Vondrášek, Jiří, Hradílek, Martin, Souček, Milan, Pichová, Iva, Majer, Pavel, Štrop, Petr, Sedlácek, Juraj, Heuser, Anke‐Mareil, Kottler, Hubert, Kräusslich, Hans‐Georg
Published in European journal of biochemistry (01.12.1997)
Published in European journal of biochemistry (01.12.1997)
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