PTEN counteracts FBXL2 to promote IP3R3- and Ca 2+ -mediated apoptosis limiting tumour growth
Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P, Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M, Pinton, Paolo, Pagano, Michele
Published in Nature (London) (22.06.2017)
Published in Nature (London) (22.06.2017)
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PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
Kuchay, Shafi, Giorgi, Carlotta, Simoneschi, Daniele, Pagan, Julia, Missiroli, Sonia, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Collazo-Lorduy, Ana, Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Sebti, Said M., Pinton, Paolo, Pagano, Michele
Published in Nature (London) (22.06.2017)
Published in Nature (London) (22.06.2017)
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Journal Article
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation
Mahajan, Kiran, Coppola, Domenico, Challa, Sridevi, Fang, Bin, Chen, Y Ann, Zhu, Weiwei, Lopez, Alexis S, Koomen, John, Engelman, Robert W, Rivera, Charlene, Muraoka-Cook, Rebecca S, Cheng, Jin Q, Schönbrunn, Ernst, Sebti, Said M, Earp, H Shelton, Mahajan, Nupam P
Published in PloS one (19.03.2010)
Published in PloS one (19.03.2010)
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Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
Siddiquee, Khandaker, Zhang, Shumin, Guida, Wayne C, Blaskovich, Michelle A, Greedy, Benjamin, Lawrence, Harshani R, Yip, M.L. Richard, Jove, Richard, McLaughlin, Mark M, Lawrence, Nicholas J, Sebti, Said M, Turkson, James
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (01.05.2007)
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Ral GTPase Down-regulation Stabilizes and Reactivates p53 to Inhibit Malignant Transformation
Tecleab, Awet, Zhang, Xiaolei, Sebti, Said M.
Published in The Journal of biological chemistry (07.11.2014)
Published in The Journal of biological chemistry (07.11.2014)
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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors
Kazi, Aslamuzzaman, Xiang, Shengyan, Yang, Hua, Chen, Liwei, Kennedy, Perry, Ayaz, Muhammad, Fletcher, Steven, Cummings, Christopher, Lawrence, Harshani R, Beato, Francisca, Kang, Ya'an, Kim, Michael P, Delitto, Andrea, Underwood, Patrick W, Fleming, Jason B, Trevino, Jose G, Hamilton, Andrew D, Sebti, Said M
Published in Clinical cancer research (01.10.2019)
Published in Clinical cancer research (01.10.2019)
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MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin
Hu, Baoli, Gilkes, Daniele M., Farooqi, Bilal, Sebti, Said M., Chen, Jiandong
Published in The Journal of biological chemistry (03.11.2006)
Published in The Journal of biological chemistry (03.11.2006)
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Combined HMG-COA reductase and prenylation inhibition in treatment of CCM
Nishimura, Sayoko, Mishra-Gorur, Ketu, Park, JinSeok, Surovtseva, Yulia V., Sebti, Said M., Levchenko, Andre, Louvi, Angeliki, Gunel, Murat
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (23.05.2017)
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Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancer
Husain, Kazim, Francois, Rony A, Yamauchi, Teruo, Perez, Marta, Sebti, Said M, Malafa, Mokenge P
Published in Molecular cancer therapeutics (01.12.2011)
Published in Molecular cancer therapeutics (01.12.2011)
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Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
Zhou, Liang, Pei, Xinyan, Zhang, Yu, Ning, Yanxia, Li, Lin, Hu, Xiaoyan, Chalasani, Sri Lakshmi, Sharma, Kanika, Nkwocha, Jewel, Yu, Jonathan, Bandyopadhyay, Dipankar, Sebti, Said M, Grant, Steven
Published in Molecular cancer research (01.03.2022)
Published in Molecular cancer research (01.03.2022)
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Phase II Study of the Mitogen-Activated Protein Kinase 1/2 Inhibitor Selumetinib in Patients With Advanced Hepatocellular Carcinoma
O'NEIL, Bert H, GOFF, Laura W, SEBTI, Said M, SULLIVAN, Daniel M, WOOK KAUH, John Sae, STROSBERG, Jonathan R, BEKAII-SAAB, Tanios S, LEE, Ruey-Min, KAZI, Aslamuzzaman, MOORE, Dominic T, LEAROYD, Maria, LUSH, Richard M
Published in Journal of clinical oncology (10.06.2011)
Published in Journal of clinical oncology (10.06.2011)
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Mevalonate Metabolism Regulates Basal Breast Cancer Stem Cells and Is a Potential Therapeutic Target
Ginestier, Christophe, Monville, Florence, Wicinski, Julien, Cabaud, Olivier, Cervera, Nathalie, Josselin, Emmanuelle, Finetti, Pascal, Guille, Arnaud, Larderet, Gaelle, Viens, Patrice, Sebti, Said, Bertucci, François, Birnbaum, Daniel, Charafe-Jauffret, Emmanuelle
Published in Stem cells (Dayton, Ohio) (01.07.2012)
Published in Stem cells (Dayton, Ohio) (01.07.2012)
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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
Carbone, Michele, Amelio, Ivano, Affar, El Bachir, Brugarolas, James, Cannon-Albright, Lisa A, Cantley, Lewis C., Cavenee, Webster K., Chen, Zhijian, Croce, Carlo M., Andrea, Alan D’, Gandara, David, Giorgi, Carlotta, Jia, Wei, Lan, Qing, Mak, Tak Wah, Manley, James L., Mikoshiba, Katsuhiko, Onuchic, Jose N, Pass, Harvey I., Pinton, Paolo, Prives, Carol, Rothman, Nathaniel, Sebti, Said M., Turkson, James, Wu, Xifeng, Yang, Haining, Yu, Herbert, Melino, Gerry
Published in Cell death and differentiation (01.11.2018)
Published in Cell death and differentiation (01.11.2018)
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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
Phan, Jason, Li, Zhenyu, Kasprzak, Agnieszka, Li, Baozong, Sebti, Said, Guida, Wayne, Schönbrunn, Ernst, Chen, Jiandong
Published in The Journal of biological chemistry (15.01.2010)
Published in The Journal of biological chemistry (15.01.2010)
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Inhibiting Isoprenylation Suppresses FcεRI-Mediated Mast Cell Function and Allergic Inflammation
Dailey, Jordan M, Kee, Sydney A, Tharakan, Anuj, Kazi, Aslamuzzaman, Burchett, Jason R, Kolawole, Elizabeth Motunrayo, Boyd Ballance, William, Kotha, Aditya, Le, Quang T, Schwartz, Lawrence B, Straus, David B, Martin, Rebecca K, Sebti, Said M, Ryan, John J
Published in The Journal of immunology (1950) (15.08.2023)
Published in The Journal of immunology (1950) (15.08.2023)
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Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway
NEFEDOVA, Yulia, NAGARAJ, Srinivas, ROSENBAUER, Amsler, MURO-CACHO, Carlos, SEBTI, Said M, GABRILOVICH, Dmitry I
Published in Cancer research (Chicago, Ill.) (15.10.2005)
Published in Cancer research (Chicago, Ill.) (15.10.2005)
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Development of Highly Potent and Selective Diaminothiazole Inhibitors of Cyclin-Dependent Kinases
Schonbrunn, Ernst, Betzi, Stephane, Alam, Riazul, Martin, Mathew P, Becker, Andreas, Han, Huijong, Francis, Rawle, Chakrasali, Ramappa, Jakkaraj, Sudhakar, Kazi, Aslamuzzaman, Sebti, Said M, Cubitt, Christopher L, Gebhard, Anthony W, Hazlehurst, Lori A, Tash, Joseph S, Georg, Gunda I
Published in Journal of medicinal chemistry (23.05.2013)
Published in Journal of medicinal chemistry (23.05.2013)
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