Quantitative single cell determination of ERK phosphorylation and regulation in relapsed and refractory primary acute myeloid leukemia
RICCIARDI, M. R, MCQUEEN, T, CHISM, D, MILELLA, M, ESTEY, E, KALDJIAN, E, SEBOLT-LEOPOLD, J, KONOPLEVA, M, ANDREEFF, M
Published in Leukemia (01.09.2005)
Published in Leukemia (01.09.2005)
Get full text
Journal Article
Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo
Sebolt-Leopold, Judith S, Dudley, David T, Herrera, Roman, Becelaere, Keri Van, Wiland, Amy, Gowan, Richard C, Tecle, Haile, Barrett, Stephen D, Bridges, Alexander, Przybranowski, Sally, Leopold, W.R, Saltiel, Alan R
Published in Nature medicine (01.07.1999)
Published in Nature medicine (01.07.1999)
Get full text
Journal Article
C-Terminal Modifications of Histidyl-N-benzylglycinamides To Give Improved Inhibition of Ras Farnesyltransferase, Cellular Activity, and Anticancer Activity in Mice
McNamara, Dennis J, Dobrusin, Ellen, Leonard, Daniele M, Shuler, Kevon R, Kaltenbronn, James S, Quin, John, Bur, Scott, Thomas, Charles E, Doherty, Annette M, Scholten, Jeffrey D, Zimmerman, Karen K, Gibbs, Barbara S, Gowan, Richard C, Latash, Michael P, Leopold, Wilbur R, Przybranowski, Sally A, Sebolt-Leopold, Judith S
Published in Journal of medicinal chemistry (10.10.1997)
Published in Journal of medicinal chemistry (10.10.1997)
Get full text
Journal Article
Effect of pyrazoloacridine (NSC 366140) on DNA topoisomerases I and II
Adjei, A A, Charron, M, Rowinsky, E K, Svingen, P A, Miller, J, Reid, J M, Sebolt-Leopold, J, Ames, M M, Kaufmann, S H
Published in Clinical cancer research (01.03.1998)
Get full text
Published in Clinical cancer research (01.03.1998)
Journal Article
Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents
Sebolt-Leopold, J.S., Vincent, P.W., Beningo, K.A., Elliott, W.L., Leopold, W.R., Heffner, T.G., Wiley, J.N., Stier, M.A., Suto, M.J.
Published in International journal of radiation oncology, biology, physics (1992)
Published in International journal of radiation oncology, biology, physics (1992)
Get full text
Journal Article
Conference Proceeding
Protein prenylation: from discovery to prospects for cancer treatment
Gelb, Michael H, Scholten, Jeffrey D, Sebolt-Leopold, Judith S
Published in Current opinion in chemical biology (01.02.1998)
Published in Current opinion in chemical biology (01.02.1998)
Get full text
Journal Article
BRAF mutation predicts sensitivity to MEK inhibition
Rosen, Neal, Solit, David B, Garraway, Levi A, Pratilas, Christine A, Sawai, Ayana, Getz, Gad, Basso, Andrea, Ye, Qing, Lobo, Jose M, She, Yuhong, Osman, Iman, Golub, Todd R, Sebolt-Leopold, Judith, Sellers, William R
Published in Nature (19.01.2006)
Published in Nature (19.01.2006)
Get full text
Journal Article
Structure−Activity Relationships of Cysteine-Lacking Pentapeptide Derivatives That Inhibit ras Farnesyltransferase
Leonard, Daniele M, Shuler, Kevon R, Poulter, Cynthia J, Eaton, Scott R, Sawyer, Tomi K, Hodges, John C, Su, Ti-Zhi, Scholten, Jeffrey D, Gowan, Richard C, Sebolt-Leopold, Judith S, Doherty, Annette M
Published in Journal of medicinal chemistry (17.01.1997)
Published in Journal of medicinal chemistry (17.01.1997)
Get full text
Journal Article
Phase I and Pharmacodynamic Study of the Oral MEK Inhibitor CI-1040 in Patients With Advanced Malignancies
Lorusso, Patricia M, Adjei, Alex A, Varterasian, Mary, Gadgeel, Shirish, Reid, Joel, Mitchell, David Y, Hanson, Lorelei, DeLuca, Pamela, Bruzek, Laura, Piens, Jill, Asbury, Peggy, Van Becelaere, Keri, Herrera, Roman, Sebolt-Leopold, Judith, Meyer, Mark B
Published in Journal of clinical oncology (10.08.2005)
Published in Journal of clinical oncology (10.08.2005)
Get full text
Journal Article
Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition
Hasemann, Charles A, Ohren, Jeffrey F, Chen, Huifen, Pavlovsky, Alexander, Whitehead, Christopher, Zhang, Erli, Kuffa, Peter, Yan, Chunhong, McConnell, Patrick, Spessard, Cindy, Banotai, Craig, Mueller, W Thomas, Delaney, Amy, Omer, Charles, Sebolt-Leopold, Judith, Dudley, David T, Leung, Iris K, Flamme, Cathlin, Warmus, Joseph, Kaufman, Michael, Barrett, Stephen, Tecle, Haile
Published in Nature structural & molecular biology (01.12.2004)
Published in Nature structural & molecular biology (01.12.2004)
Get full text
Journal Article
Novel limonene phosphonate and farnesyl diphosphate analogues: design, synthesis, and evaluation as potential protein-farnesyl transferase inhibitors
Eummer, J T, Gibbs, B S, Zahn, T J, Sebolt-Leopold, J S, Gibbs, R A
Published in Bioorganic & medicinal chemistry (01.02.1999)
Published in Bioorganic & medicinal chemistry (01.02.1999)
Get full text
Journal Article
Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor
Sebolt-Leopold, Judith S., Scavone, Sylvia V.
Published in International journal of radiation oncology, biology, physics (1992)
Published in International journal of radiation oncology, biology, physics (1992)
Get full text
Journal Article
Conference Proceeding
Comparative molecular field analysis of in vitro growth inhibition of L1210 and HCT-8 cells by some pyrazoloacridines
Horwitz, Jerome P, Massova, Irina, Wiese, Thomas E, Wozniak, Antoinette J, Corbett, Thomas H, Sebolt-Leopold, Judith S, Capps, David B, Leopold, Wilbur R
Published in Journal of medicinal chemistry (12.11.1993)
Published in Journal of medicinal chemistry (12.11.1993)
Get full text
Journal Article
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908)
Cole, S., Stratford, I.J., Fielden, E.M., Adams, G.E., Leopold, W., Elliott, W., Suto, M., Sebolt-Leopold, J.
Published in International journal of radiation oncology, biology, physics (1992)
Published in International journal of radiation oncology, biology, physics (1992)
Get full text
Journal Article
Conference Proceeding
The Effects of a Novel MEK Inhibitor PD184161 on MEK-ERK Signaling and Growth in Human Liver Cancer
Klein, Patrick J., Schmidt, C. Max, Wiesenauer, Chad A., Choi, Jennifer N., Gage, Earl A., Yip-Schneider, Michele T., Wiebke, Eric A., Wang, Yufang, Omer, Charles, Sebolt-Leopold, Judith S.
Published in Neoplasia (New York, N.Y.) (01.01.2006)
Published in Neoplasia (New York, N.Y.) (01.01.2006)
Get full text
Journal Article