289 Progress in drugging CYP1A1, 1B1 and CYP2W1 overexpressed in cancer
Pors, K, Le Morvan, V, Travica, S, Shnyder, S.D, Sutherland, M, Sheldrake, H.M, Searcey, M, Johansson, I, Mkrtchian, S, Loadman, P.M, Robert, J, Ingelman-Sundberg, M, Patterson, L.H
Published in European journal of cancer (1990) (01.11.2014)
Published in European journal of cancer (1990) (01.11.2014)
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Journal Article
Synthesis and Evaluation of 1,2,8,8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the Parent Alkylation Subunit of CC-1065 and the Duocarmycins: Impact of the Alkylation Subunit Substituents and Its Implications for DNA Alkylation Catalysis
Boger, Dale L, Santillán, Alejandro, Searcey, Mark, Brunette, Steven R, Wolkenberg, Scott E, Hedrick, Michael P, Jin, Qing
Published in Journal of organic chemistry (30.06.2000)
Published in Journal of organic chemistry (30.06.2000)
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Antitumour antibiotics with potent activity against multidrug resistant (MDR) Staphylococcus aureus: a new approach to targeting resistant bacteria
Casely-Hayford, M A, Kerr, N Ortuzar, Smith, E, Gibbons, S, Searcey, M
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.11.2005)
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01.11.2005)
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Journal Article
331 POSTER CYP1A1 activation and pharmacokinetics of a novel chloromethylpyrrollolindoline with potential as a tumour selective prodrug
Race, A.D, Pors, K, Shnyder, S.D, Cooper, T.C, Sheldrake, H.M, Searcey, M, Patterson, L.H, Loadman, P.M
Published in European journal of cancer supplements (2008)
Published in European journal of cancer supplements (2008)
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Journal Article
Polyclonal antibody-catalysed amide hydrolysis
GALLACHER, G, SEARCEY, M, JACKSON, C. S, BROCKLEHURST, K
Published in Biochemical journal (15.06.1992)
Published in Biochemical journal (15.06.1992)
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Journal Article
Re-engineering of the Duocarmycin Structural Architecture Enables Bioprecursor Development Targeting CYP1A1 and CYP2W1 for Biological Activity
Sheldrake, Helen M, Travica, Sandra, Johansson, Inger, Loadman, Paul M, Sutherland, Mark, Elsalem, Lina, Illingworth, Nicola, Cresswell, Alexander J, Reuillon, Tristan, Shnyder, Steven D, Mkrtchian, Souren, Searcey, Mark, Ingelman-Sundberg, Magnus, Patterson, Laurence H, Pors, Klaus
Published in Journal of medicinal chemistry (08.08.2013)
Published in Journal of medicinal chemistry (08.08.2013)
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Journal Article
A polyclonal antibody preparation with Michaelian catalytic properties
GALLACHER, G, JACKSON, C. S, SEARCEY, M, BADMAN, G. T, GOEL, R, TOPHAM, C. M, MELLOR, G. W, BROCKLEHURST, K
Published in Biochemical journal (01.11.1991)
Published in Biochemical journal (01.11.1991)
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Journal Article
Polyclonal-antibody-catalysed hydrolysis of an aryl nitrophenyl carbonate
Gallacher, G, Jackson, C S, Topham, C M, Searcey, M, Turner, B C, Badman, G T, Brocklehurst, K
Published in Biochemical Society transactions (01.08.1990)
Published in Biochemical Society transactions (01.08.1990)
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Journal Article
Efficient Solid-Phase-Based Total Synthesis of the Bisintercalator TANDEM
Malkinson, John P, Anim, Michael K, Zloh, Mire, Searcey, Mark, Hampshire, Andrew J, Fox, Keith R
Published in Journal of organic chemistry (16.09.2005)
Published in Journal of organic chemistry (16.09.2005)
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Journal Article
Progress in drugging CYP1A1, 1B1 and CYP2W1 overexpressed in cancer
Pors, K, Le Morvan, V, Travica, S, Shnyder, SD, Sutherland, M, Sheldrake, HM, Searcey, M, Johansson, I, Mkrtchian, S, Loadman, PM, Robert, J, Ingelman-Sundberg, M, Patterson, LH
Published in EUROPEAN JOURNAL OF CANCER (2014)
Published in EUROPEAN JOURNAL OF CANCER (2014)
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Conference Proceeding
CYP2W1 as a novel therapeutic target in colon cancer
Pors, K, Loadman, PM, Travica, S, Shnyder, SD, Sutherland, M, Sheldrake, H, Searcey, M, Johansson, I, Mkrtchian, S, Ingelman-Sundberg, M, Patterson, LH
Published in CANCER RESEARCH (2014)
Published in CANCER RESEARCH (2014)
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Conference Proceeding
Development of Nonsymmetrical 1,4-Disubstituted Anthraquinones That Are Potently Active against Cisplatin-Resistant Ovarian Cancer Cells
Pors, Klaus, Plumb, Jane A, Brown, Robert, Teesdale-Spittle, Paul, Searcey, Mark, Smith, Paul J, Patterson, Laurence H
Published in Journal of medicinal chemistry (20.10.2005)
Published in Journal of medicinal chemistry (20.10.2005)
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Journal Article
Design and synthesis of a DNA-crosslinking azinomycin analogue
Casely-Hayford, MA, Pors, K, James, CH, Patterson, LH, Hartley, JA, Searcey, M
Published in Organic & biomolecular chemistry (07.10.2005)
Published in Organic & biomolecular chemistry (07.10.2005)
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Journal Article
Truncated azinomycin analogues intercalate into DNA
Casely-Hayford, Maxwell A., Pors, Klaus, Patterson, Laurence H., Gerner, Clive, Neidle, Stephen, Searcey, Mark
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
Published in Bioorganic & medicinal chemistry letters (01.02.2005)
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