Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1
Westaway, Susan M., Thompson, Mervyn, Rami, Harshad K., Stemp, Geoffrey, Trouw, Leontine S., Mitchell, Darren J., Seal, Jon T., Medhurst, Stephen J., Lappin, Sarah C., Biggs, James, Wright, James, Arpino, Sandra, Jerman, Jeffrey C., Cryan, Jennifer E., Holland, Vicky, Winborn, Kim Y., Coleman, Tanya, Stevens, Alexander J., Davis, John B., Gunthorpe, Martin J.
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate
Westaway, Susan M, Brown, Samantha L, Fell, Stephen C. M, Johnson, Christopher N, MacPherson, David T, Mitchell, Darren J, Myatt, James W, Stanway, Steven J, Seal, Jon T, Stemp, Geoffrey, Thompson, Mervyn, Lawless, Kirk, McKay, Fiona, Muir, Alison I, Barford, Jonathan M, Cluff, Chermaine, Mahmood, Sadhia R, Matthews, Kim L, Mohamed, Shiyam, Smith, Beverley, Stevens, Alexander J, Bolton, Victoria J, Jarvie, Emma M, Sanger, Gareth J
Published in Journal of medicinal chemistry (26.02.2009)
Published in Journal of medicinal chemistry (26.02.2009)
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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists
AHMED, Mahmood, BRIGGS, Michael A, JOHNSON, Christopher N, MEDHURST, Andrew D, MITCHELL, Darren J, MOSS, Stephen F, POWLES, Jenifer, SEAL, Jon T, STEAN, Tania O, STEMP, Geoffrey, THOMPSON, Mervyn, TRAIL, Brenda, BROMIDGE, Steven M, UPTON, Neil, WINBORN, Kim, WITTY, David R, BUCK, Tania, CAMPBELL, Lorraine, DEEKS, Nigel J, GARNER, Ashley, GORDON, Laurie, HAMPRECHT, Dieter W, HOLLAND, Vicky
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor
Westaway, Susan M., Brown, Samantha L., Conway, Elizabeth, Heightman, Tom D., Johnson, Christopher N., Lapsley, Kate, Macdonald, Gregor J., MacPherson, David T., Mitchell, Darren J., Myatt, James W., Seal, Jon T., Stanway, Steven J., Stemp, Geoffrey, Thompson, Mervyn, Celestini, Paolo, Colombo, Andrea, Consonni, Alessandra, Gagliardi, Stefania, Riccaboni, Mauro, Ronzoni, Silvano, Briggs, Michael A., Matthews, Kim L., Stevens, Alexander J., Bolton, Victoria J., Boyfield, Izzy, Jarvie, Emma M., Stratton, Sharon C., Sanger, Gareth J.
Published in Bioorganic & medicinal chemistry (15.12.2008)
Published in Bioorganic & medicinal chemistry (15.12.2008)
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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT 6 receptor antagonists
Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N., Medhurst, Andrew D., Mitchell, Darren J., Moss, Stephen F., Powles, Jenifer, Seal, Jon T., Stean, Tania O., Stemp, Geoffrey, Thompson, Mervyn, Trail, Brenda, Upton, Neil, Winborn, Kim, Witty, David R.
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
Published in Bioorganic & medicinal chemistry letters (01.11.2005)
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Journal Article
Discovery of N-(3-Fluorophenyl)-1-[4-([(3S)-3-methyl-1-piperazinyl]methyl)phenylacetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate
WESTAWAY, Susan M, BROWN, Samantha L, THOMPSON, Mervyn, LAWLESS, Kirk, MCKAY, Fiona, MUIR, Alison I, BARFORD, Jonathan M, CLUFF, Chermaine, MAHMOOD, Sadhia R, MATTHEWS, Kim L, MOHAMED, Shiyam, SMITH, Beverley, FELL, Stephen C. M, STEVENS, Alexander J, BOLTON, Victoria J, JARVIE, Emma M, SANGER, Gareth J, JOHNSON, Christopher N, MACPHERSON, David T, MITCHELL, Darren J, MYATT, James W, STANWAY, Steven J, SEAL, Jon T, STEMP, Geoffrey
Published in Journal of medicinal chemistry (2009)
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Published in Journal of medicinal chemistry (2009)
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WITHDRAWN: Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists
Ahmed, Mahmood, Briggs, Michael A., Bromidge, Steven M., Buck, Tania, Campbell, Lorraine, Deeks, Nigel J., Garner, Ashley, Gordon, Laurie, Hamprecht, Dieter W., Holland, Vicky, Johnson, Christopher N., Medhurst, Andrew D., Mitchell, Darren J., Moss, Stephen F., Powles, Jenifer, Seal, Jon T., Stean, Tania O., Stemp, Geoffrey, Thompson, Mervyn, Trail, Brenda, Upton, Neil, Winborn, Kim, Witty, David R.
Published in Bioorganic & medicinal chemistry (01.07.2005)
Published in Bioorganic & medicinal chemistry (01.07.2005)
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