Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer
Scribner, Juniper A, Brown, Jennifer G, Son, Thomas, Chiechi, Michael, Li, Pam, Sharma, Sharad, Li, Hua, De Costa, Anushka, Li, Ying, Chen, Yan, Easton, Ann, Yee-Toy, Nicholas C, Chen, Francine Z, Gorlatov, Sergey, Barat, Bhaswati, Huang, Ling, Wolff, Christina R, Hooley, Jeff, Hotaling, Tim E, Gaynutdinov, Timur, Ciccarone, Valentina, Tamura, James, Koenig, Scott, Moore, Paul A, Bonvini, Ezio, Loo, Deryk
Published in Molecular cancer therapeutics (01.11.2020)
Published in Molecular cancer therapeutics (01.11.2020)
Get full text
Journal Article
Preclinical Evaluation of IMGC936, a Next Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors
Scribner, Juniper A, Hicks, Stuart W, Sinkevicius, Kerstin W, Yoder, Nicholas C, Diedrich, Gundo, Brown, Jennifer G, Lucas, Jacquelynn, Fuller, Megan E, Son, Thomas, Dastur, Anahita, Hooley, Jeff, Espelin, Christopher W, Themeles, Marian, Chen, Francine Z, Li, Ying, Chiechi, Michael, Lee, Jenny, Barat, Bhaswati, Widjaja, Lusiana, Gorlatov, Sergey, Tamura, James, Ciccarone, Valentina, Ab, Olga, McEachem, Kerry A, Koenig, Scott, Westin, Eric H, Moore, Paul A, Chittenden, Thomas, Gregory, Richard J, Bonvini, Ezio, Loo, Deryk
Published in Molecular cancer therapeutics (05.07.2022)
Published in Molecular cancer therapeutics (05.07.2022)
Get full text
Journal Article
PD-1 X CTLA-4 이중특이적 분자와 조합된 B7-H3 항체-약물 접합체의 사용 방법
KOENIG SCOTT, BOHAC GERRY CHESTER, JAMES ANGELA JOUBERT, SCRIBNER JUNIPER A, SUMROW BRADLEY JAMES, LOO DERYK
Year of Publication 27.09.2024
Get full text
Year of Publication 27.09.2024
Patent
B7-H3 항체 약물 콘쥬게이트를 단독으로 또는 조합하여 사용하는 방법
WIGGINTON JON MARC, BOHAC GERRY CHESTER, SCRIBNER JUNIPER A, LOO DERYK
Year of Publication 17.01.2023
Get full text
Year of Publication 17.01.2023
Patent
ADAM9를 표적으로 하는 면역콘쥬게이트 및 이를 이용하는 방법들
BONVINI EZIO, DIEDRICH GUNDO, JOHNSON LESLIE S, BARAT BHASWATI, HICKS STUART WILLIAM, YODER NICHOLAS C, SCRIBNER JUNIPER A, LOO DERYK
Year of Publication 28.05.2021
Get full text
Year of Publication 28.05.2021
Patent
ADAM9-결합 분자, 및 이것의 사용 방법
BONVINI EZIO, DIEDRICH GUNDO, JOHNSON LESLIE S, LOO DERYK T, BARAT BHASWATI, SCRIBNER JUNIPER A
Year of Publication 26.08.2019
Get full text
Year of Publication 26.08.2019
Patent
Abstract 950: Targeting B7-H3 in squamous cell carcinoma of the head and neck: Preclinical proof-of-concept with the investigational anti-B7-H3 antibody-drug conjugate, MGC018
Scribner, Juniper A., Chen, Francine Z., Li, Ying, Chiechi, Michael, Son, Thomas, Hooley, Jeff, Koenig, Scott, Moore, Paul A., Bonvini, Ezio, Bohac, Chet, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract 1841: IMGC936, an investigational ADAM9-targeting antibody drug conjugate, is active against patient-derived ADAM9-expressing xenograft models
Ab, Olga, Scribner, Juniper A., Sinkevicius, Kerstin, Loo, Deryk, Hicks, Stuart W., Watkins, Krystal, Chen, Francine Z., Espelin, Christopher, Themeles, Marian, Li, Ying, Bohac, Chet, McKay, Patrick Zweidler, Moore, Paul A., Sloss, Callum M., Bonvini, Ezio, Westin, Eric H.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Get full text
Journal Article
Abstract 5203: MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3, exhibits immunomodulatory activity and enhanced antitumor activity in combination with checkpoint inhibitors
Scribner, Juniper A., Chiechi, Michael, Li, Pam, Son, Thomas, Hooley, Jeff, Li, Ying, De Costa, Anushka, Lung, Peter, Yee-Toy, Nicholas, Chen, Francine, Barat, Bhaswati, Wolff, Christina, Ciccarone, Valentina, Tamura, James, Koenig, Scott, Bohac, Chet, Wigginton, Jon, Moore, Paul A., Bonvini, Ezio, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Get full text
Journal Article
Abstract 1897: Preclinical development of MGC028, an ADAM9-targeted, glycan-linked, exatecan-based antibody-drug conjugate for the treatment of solid cancers
Scribner, Juniper A., Brown, Jennifer G., Son, Thomas, Jin, Linda, McKenzie, Carroll, Nam, Viktoriya, Bush, Curtis, Quinonez, Dienis, Ford, Delta, Gonzalez, Verlene, Tamura, James, Gorlatov, Sergey, Li, Hua, Butler, Shelley, Bonvini, Ezio, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 1904: Preclinical development of MGC026, a glycan-linked, exatecan-based antibody-drug conjugate (ADC) targeting B7-H3 for solid cancer
Scribner, Juniper A., Brown, Jennifer G., Son, Thomas, Jin, Linda, McKenzie, Carroll, Nam, Viktoriya, Bush, Curtis, Quinonez, Dienis, Tamura, James, Gorlatov, Sergey, Li, Hua, Butler, Shelley, Bonvini, Ezio, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Get full text
Journal Article
Abstract 42: Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer
Son, Thomas, Scribner, Juniper A., Hooley, Jeff, Chiechi, Michael, Li, Pam, Hotaling, Timothy E., Costa, Anushka De, Chen, Yan, Chen, Francine, Barat, Bhaswati, Ciccarone, Valentina, Gaynutdinov, Timur, Tamura, James, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract 37: Novel antibody-drug conjugates targeting ADAM9-expressing solid tumors demonstrate potent preclinical activity
Hicks, Stuart W., Yoder, Nicholas C., Loo, Deryk, Muvaffak, Asli, Zhou, Yinghui, Fuller, Megan E., McShea, Molly A., Themeles, Marian, Mucciarone, Katherine H., Scribner, Juniper A., Barat, Bhaswati, Sun, Thomas, Tamura, James, Chen, Francine Z., Donahue, Kerry A., Chittenden, Tom
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract 820: Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer
Scribner, Juniper A., Brown, Jennifer G., Sharma, Sharad, Li, Hua, Chiechi, Michael, Li, Pam, Son, Thomas, Costa, Anushka De, Chen, Yan, Chen, Francine, Barat, Bhaswati, Huang, Ling, Wolff, Christina, Hooley, Jeff, Hotaling, Tim E., Gaynutdinov, Timur, Ciccarone, Valentina, Tamura, James, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Get full text
Journal Article
Abstract 330: Targeting B7-H3 in prostate cancer: Preclinical proof of concept with MGC018, an investigational anti-B7-H3 antibody-drug conjugate
Scribner, Juniper A., Chen, Francine Z., De Costa, Anushka, Li, Ying, Chiechi, Michael, Son, Thomas, Hooley, Jeff, Li, Jonathan, Koenig, Scott, Bohac, Chet, Bonvini, Ezio, Moore, Paul A., Loo, Deryk
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Get full text
Journal Article
Abstract 38: Target validation, antibody discovery and preclinical data supporting ADAM9 as an antibody-drug conjugate therapeutic target for solid tumors
Scribner, Juniper A., Barat, Bhaswati, Hicks, Stuart W., Yoder, Nicholas C., Son, Thomas, Widjaja, Lusiana, Diedrich, Gundo, Gorlatov, Sergey, Hooley, Jeff, Easton, Ann, Lung, Peter, Costa, Anushka De, Chen, Francine, Chiechi, Michael, Li, Pam, Licea, Monica, Hotaling, Timothy E., Spliedt, Michael, Ciccarone, Valentina, Gantt, Nadia, Tamura, James, Fuller, Megan E., McShea, Molly, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio, Loo, Deryk
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Get full text
Journal Article
Abstract 1201: Anti-B7-H3 antibody-drug conjugates as potential therapeutics for solid cancer
Loo, Deryk, Scribner, Juniper A., Son, Thomas, Hooley, Jeff, Hotaling, Timothy, Chiechi, Michael, Li, Pam, De Costa, Anushka, Chen, Yan, Easton, Ann, Chen, Francine Z., Barat, Bhaswati, Ciccarone, Valentina, Tamura, James, Kubik, Mark, Koenig, Scott, Johnson, Syd, Moore, Paul A., Bonvini, Ezio
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Get full text
Journal Article
METHODS FOR THE USE OF A B7-H3 ANTIBODY-DRUG CONJUGATE ALONE OR IN COMBINATION
BOHAC, Gerry Chester, SCRIBNER, Juniper A, LOO, Deryk, WIGGINTON, Jon Marc
Year of Publication 03.07.2024
Get full text
Year of Publication 03.07.2024
Patent