Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
Fingerlin, Tasha E, Murphy, Elissa, Zhang, Weiming, Peljto, Anna L, Brown, Kevin K, Steele, Mark P, Loyd, James E, Cosgrove, Gregory P, Lynch, David, Groshong, Steve, Collard, Harold R, Wolters, Paul J, Bradford, Williamson Z, Kossen, Karl, Seiwert, Scott D, du Bois, Roland M, Garcia, Christine Kim, Devine, Megan S, Gudmundsson, Gunnar, Isaksson, Helgi J, Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F, Lancaster, Lisa H, Cogan, Joy D, Mason, Wendi R, Maher, Toby M, Molyneaux, Philip L, Wells, Athol U, Moffatt, Miriam F, Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Walek, Dinesha S, Daniel, Jerry J, Kamatani, Yoichiro, Zelenika, Diana, Smith, Keith, McKean, David, Pedersen, Brent S, Talbert, Janet, Kidd, Raven N, Markin, Cheryl R, Beckman, Kenneth B, Lathrop, Mark, Schwarz, Marvin I, Schwartz, David A
Published in Nature genetics (01.06.2013)
Published in Nature genetics (01.06.2013)
Get full text
Journal Article
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
Noth, Imre, Zhang, Yingze, Ma, Shwu-Fan, Flores, Carlos, Barber, Mathew, Huang, Yong, Broderick, Steven M, Wade, Michael S, Hysi, Pirro, Scuirba, Joseph, Richards, Thomas J, Juan-Guardela, Brenda M, Vij, Rekha, Han, MeiLan K, Martinez, Fernando J, Kossen, Karl, Seiwert, Scott D, Christie, Jason D, Nicolae, Dan, Kaminski, Naftali, Garcia, Joe G N
Published in The lancet respiratory medicine (01.06.2013)
Published in The lancet respiratory medicine (01.06.2013)
Get more information
Journal Article
Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)
Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Get full text
Journal Article
Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution
LIM, Sharlene R, XIAOLI QIN, NAJERA, Isabel, SMITH, Patrick, ZEUZEM, Stefan, KOSSEN, Karl, SARRAZIN, Christophe, SEIWERT, Scott D, SUSSER, Simone, NICHOLAS, John B, LANGE, Christian, HERRMANN, Eva, JIN HONG, ARFSTEN, Ann, HOOI, Lisa, BRADFORD, Williamson
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
Published in Antimicrobial Agents and Chemotherapy (01.01.2012)
Get full text
Journal Article
Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior
Rajagopalan, Ravi, Misialek, Shawn, Stevens, Sarah K, Myszka, David G, Brandhuber, Barbara J, Ballard, Joshua A, Andrews, Steven W, Seiwert, Scott D, Kossen, Karl
Published in Biochemistry (Easton) (24.03.2009)
Published in Biochemistry (Easton) (24.03.2009)
Get full text
Journal Article
Danoprevir Monotherapy Decreases Inflammatory Markers in Patients with Chronic Hepatitis C Virus Infection
SCHAEFER, Caralee J, KOSSEN, Karl, LIM, Sharlene R, LIN, Jiing-Huey, LIN PAN, BRADFORD, Williamson, SMITH, Patrick F, SEIWERT, Scott D
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
Get full text
Journal Article
Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis
Peljto, Anna L, Zhang, Yingze, Fingerlin, Tasha E, Ma, Shwu-Fan, Garcia, Joe G. N, Richards, Thomas J, Silveira, Lori J, Lindell, Kathleen O, Steele, Mark P, Loyd, James E, Gibson, Kevin F, Seibold, Max A, Brown, Kevin K, Talbert, Janet L, Markin, Cheryl, Kossen, Karl, Seiwert, Scott D, Murphy, Elissa, Noth, Imre, Schwarz, Marvin I, Kaminski, Naftali, Schwartz, David A
Published in JAMA : the journal of the American Medical Association (05.06.2013)
Published in JAMA : the journal of the American Medical Association (05.06.2013)
Get full text
Journal Article
HCV NS5B polymerase inhibitors 1: Synthesis and in vitro activity of 2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives
Wang, Guangyi, He, Yanzhen, Sun, Jun, Das, Debasis, Hu, Mougang, Huang, Jianhua, Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Ravi Rajagopalan, P.T., Stoycheva, Antitsa, Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Get full text
Journal Article
HCV NS5B polymerase inhibitors 3: Synthesis and in vitro activity of 3-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-4-hydroxy-2H-quinolizin-2-one derivatives
Wang, Guangyi, Zhang, Laiguo, Wu, Xiaomin, Das, Debasis, Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Ravi Rajagopalan, P.T., Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Get full text
Journal Article
Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease
Jiang, Yutong, Andrews, Steven W., Condroski, Kevin R., Buckman, Brad, Serebryany, Vlad, Wenglowsky, Steve, Kennedy, April L., Madduru, Machender R., Wang, Bin, Lyon, Michael, Doherty, George A., Woodard, Benjamin T., Lemieux, Christine, Do, Mary Geck, Zhang, Hailong, Ballard, Joshua, Vigers, Guy, Brandhuber, Barbra J., Stengel, Peter, Josey, John A., Beigelman, Leonid, Blatt, Lawrence, Seiwert, Scott D.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
Get full text
Journal Article
Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study
Forestier, Nicole, Larrey, Dominique, Guyader, Dominique, Marcellin, Patrick, Rouzier, Régine, Patat, Alain, Smith, Patrick, Bradford, Williamson, Porter, Steven, Blatt, Lawrence, Seiwert, Scott D, Zeuzem, Stefan
Published in Journal of hepatology (01.06.2011)
Published in Journal of hepatology (01.06.2011)
Get full text
Journal Article
Zeptomole detection of a viral nucleic acid using a target-activated ribozyme
Vaish, Narendra K, Jadhav, Vasant R, Kossen, Karl, Pasko, Christopher, Andrews, Lori E, McSwiggen, James A, Polisky, Barry, Seiwert, Scott D
Published in RNA (Cambridge) (01.09.2003)
Published in RNA (Cambridge) (01.09.2003)
Get full text
Journal Article
Recent advances in drug discovery of benzothiadiazine and related analogs as HCV NS5B polymerase inhibitors
Das, Debasis, Hong, Jian, Chen, Shu-Hui, Wang, Guangyi, Beigelman, Leonid, Seiwert, Scott D., Buckman, Brad O.
Published in Bioorganic & medicinal chemistry (15.08.2011)
Published in Bioorganic & medicinal chemistry (15.08.2011)
Get full text
Journal Article
Antiviral Activity of Danoprevir (ITMN-191/ RG7227) in Combination With Pegylated Interferon alpha -2a and Ribavirin in Patients With Hepatitis C
estier, Nicole, Larrey, Dominique, Marcellin, Patrick, Guyader, Dominique, Patat, Alain, Rouzier, Regine, Smith, Patrick F, Qin, Xiaoli, Lim, Sharlene, Bradford, Williamson, Porter, Steven, Seiwert, Scott D, Zeuzem, Stefan
Published in The Journal of infectious diseases (15.08.2011)
Published in The Journal of infectious diseases (15.08.2011)
Get full text
Journal Article
Antiviral Activity of Danoprevir (ITMN-191/RG7227) in Combination With Pegylated Interferon α-2a and Ribavirin in Patients With Hepatitis C
Forestier, Nicole, Larrey, Dominique, Marcellin, Patrick, Guyader, Dominique, Patat, Alain, Rouzier, Regine, Smith, Patrick F., Qin, Xiaoli, Lim, Sharlene, Bradford, Williamson, Porter, Steven, Seiwert, Scott D., Zeuzem, Stefan
Published in The Journal of infectious diseases (15.08.2011)
Published in The Journal of infectious diseases (15.08.2011)
Get full text
Journal Article
Corrigendum: Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
Fingerlin, Tasha E, Murphy, Elissa, Zhang, Weiming, Peljto, Anna L, Brown, Kevin K, Steele, Mark P, Loyd, James E, Cosgrove, Gregory P, Lynch, David, Groshong, Steve, Collard, Harold R, Wolters, Paul J, Bradford, Williamson Z, Kossen, Karl, Seiwert, Scott D, du Bois, Roland M, Garcia, Christine Kim, Devine, Megan S, Gudmundsson, Gunnar, Isaksson, Helgi J, Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F, Lancaster, Lisa H, Cogan, Joy D, Mason, Wendi R, Maher, Toby M, Molyneaux, Philip L, Wells, Athol U, Moffatt, Miriam F, Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Walek, Dinesha S, Daniel, Jerry J, Kamatani, Yoichiro, Zelenika, Diana, Smith, Keith, McKean, David, Pedersen, Brent S, Talbert, Janet, Kidd, Raven N, Markin, Cheryl R, Beckman, Kenneth B, Lathrop, Mark, Schwarz, Marvin I, Schwartz, David A
Published in Nature genetics (01.11.2013)
Published in Nature genetics (01.11.2013)
Get full text
Journal Article
Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia
Fingerlin, Tasha E, Zhang, Weiming, Yang, Ivana V, Ainsworth, Hannah C, Russell, Pamela H, Blumhagen, Rachel Z, Schwarz, Marvin I, Brown, Kevin K, Steele, Mark P, Loyd, James E, Cosgrove, Gregory P, Lynch, David A, Groshong, Steve, Collard, Harold R, Wolters, Paul J, Bradford, Williamson Z, Kossen, Karl, Seiwert, Scott D, du Bois, Roland M, Garcia, Christine Kim, Devine, Megan S, Gudmundsson, Gunnar, Isaksson, Helgi J, Kaminski, Naftali, Zhang, Yingze, Gibson, Kevin F, Lancaster, Lisa H, Maher, Toby M, Molyneaux, Philip L, Wells, Athol U, Moffatt, Miriam F, Selman, Moises, Pardo, Annie, Kim, Dong Soon, Crapo, James D, Make, Barry J, Regan, Elizabeth A, Walek, Dinesha S, Daniel, Jerry J, Kamatani, Yoichiro, Zelenika, Diana, Murphy, Elissa, Smith, Keith, McKean, David, Pedersen, Brent S, Talbert, Janet, Powers, Julia, Markin, Cheryl R, Beckman, Kenneth B, Lathrop, Mark, Freed, Brian, Langefeld, Carl D, Schwartz, David A
Published in BMC genetics (07.06.2016)
Published in BMC genetics (07.06.2016)
Get full text
Journal Article
HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives
Wang, Guangyi, Lei, Huoxing, Wang, Xiaofang, Das, Debasis, Hong, Jian, Mackinnon, Colin H., Coulter, Thomas S., Montalbetti, Christian A.G.N., Mears, Richard, Gai, Xinjie, Bailey, Sarah E., Ruhrmund, Donald, Hooi, Lisa, Misialek, Shawn, Rajagopalan, P.T. Ravi, Cheng, Robert K.Y., Barker, John J., Felicetti, Brunella, Schönfeld, Dorian L., Stoycheva, Antitsa, Buckman, Brad O., Kossen, Karl, Seiwert, Scott D., Beigelman, Leonid
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Get full text
Journal Article
Monitoring post-translational modification of proteins with allosteric ribozymes
Vaish, Narendra K, Seiwert, Scott D, Dong, Fang, Andrews, Lori, Schweppe, Rebecca E, Ahn, Natalie G, Blatt, Lawrence
Published in Nature biotechnology (01.08.2002)
Published in Nature biotechnology (01.08.2002)
Get full text
Journal Article