Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (14.10.2021)
Published in Journal of medicinal chemistry (14.10.2021)
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Journal Article
Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats
Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility
Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David, Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.
Published in Journal of medicinal chemistry (23.05.2024)
Published in Journal of medicinal chemistry (23.05.2024)
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Journal Article
Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function
Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P
Published in Journal of medicinal chemistry (28.10.2021)
Published in Journal of medicinal chemistry (28.10.2021)
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Journal Article
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases
Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Published in Nature medicine (01.03.2012)
Published in Nature medicine (01.03.2012)
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Journal Article
Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator
Collibee, Scott E, Bergnes, Gustave, Muci, Alexander, Browne, William F, Garard, Marc, Hinken, Aaron C, Russell, Alan J, Suehiro, Ion, Hartman, James, Kawas, Raja, Lu, Pu-Ping, Lee, Kenneth H, Marquez, David, Tomlinson, Matthew, Xu, Donghong, Kennedy, Adam, Hwee, Darren, Schaletzky, Julia, Leung, Kwan, Malik, Fady I, Morgans, David J, Morgan, Bradley P
Published in ACS medicinal chemistry letters (12.04.2018)
Published in ACS medicinal chemistry letters (12.04.2018)
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Journal Article
Asymmetric Catalysis with Libraries of Palladium β-Turn Phosphine Complexes
Gilbertson, Scott R, Collibee, Scott E, Agarkov, Anton
Published in Journal of the American Chemical Society (12.07.2000)
Published in Journal of the American Chemical Society (12.07.2000)
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Journal Article
Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin
Morgan, Bradley P, Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W, Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M, Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A, Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I, Morgans, David J
Published in ACS medicinal chemistry letters (09.12.2010)
Published in ACS medicinal chemistry letters (09.12.2010)
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Journal Article
Catalysis with Phosphine-Containing Amino Acids in Various “Turn” Motifs
Agarkov, Anton, Greenfield, Scott J, Ohishi, Takahiro, Collibee, Scott E, Gilbertson, Scott R
Published in Journal of organic chemistry (12.11.2004)
Published in Journal of organic chemistry (12.11.2004)
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Journal Article
BCl3- and TiCl4-Mediated Reductions of β-Hydroxy Ketones
Sarko, Christopher R, Collibee, Scott E, Knorr, Allison L, DiMare, Marcello
Published in Journal of organic chemistry (09.02.1996)
Published in Journal of organic chemistry (09.02.1996)
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Journal Article
PARTICULAR AMINO-PYRIDAZINE, COMPOSITION THEREOF, AND METHOD OF THEIR USE
BERGNES GUSTAVE, SCOTT COLLIBEE, MORGAN BRADLEY P, JEFFREY WARRINGTON, CHIHYUAN CHUANG, JEFF GARDINA, LUKE W ASHCRAFT, QIAN XIANGPING, YANG ZHE, LU PU-PING, ALEX R MUCI, ANTONIO ROMERO
Year of Publication 15.09.2016
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Year of Publication 15.09.2016
Patent
BICYCLIC PIPERAZINONES AND THERAPEUTIC USES THEREOF
KUROSAKI, Toshio, MAKINO, Takuya, HONJO, Eriko, EVANS, Chris, KOIZUMI, Yuka, COLLIBEE, Scott, MORGAN, Bradley P
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
Patent
NAMPT MODULATORS
TOCHIMOTO, Todd, LU, Pu-Ping, GARCIA, Alfredo, ROMERO, Antonio, WANG, Wenyue, SHEN, Minxing, EVANS, Christopher, COLLIBEE, Scott E
Year of Publication 22.08.2024
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Year of Publication 22.08.2024
Patent
NAMPT MODULATORS
TOCHIMOTO, Todd, LU, Pu-Ping, GARCIA, Alfredo, ROMERO, Antonio, WANG, Wenyue, SHEN, Minxing, EVANS, Christopher, COLLIBEE, Scott E
Year of Publication 27.06.2024
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Year of Publication 27.06.2024
Patent
Bicyclic 1,4-diazepanones and therapeutic uses thereof
Yamaki, Susumu, Katoh, Naoto, Kuriwaki, Ikumi, Koizumi, Yuka, Wang, Wenyue, Collibee, Scott, Yamasaki, Makoto, Makino, Takuya, Morgan, Bradley P, Tsuchiya, Kazuyuki, Sekioka, Ryuichi, Kurosaki, Toshio, Honjo, Eriko, Evans, Chris, Lu, Pu-Ping
Year of Publication 14.05.2024
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Year of Publication 14.05.2024
Patent
AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS
QIAN, Xiangping, CHUANG, Chihyuan, YANG, Zhe, LU, Pu-Ping, ROMERO, Antonio, WARRINGTON, Jeffrey, COLLIBEE, Scott, MORGAN, Bradley P, MUCI, Alex R, BERGNES, Gustave
Year of Publication 26.01.2023
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Year of Publication 26.01.2023
Patent
SLOW SKELETAL TROPONIN ACTIVATORS
GARARD, Marc, TANAKA, Hiroaki, SATO, Shota, SAMI, Yuichi, ABE, Tomoaki, INAGAKI, Yusuke, IMADA, Sunao, ISHIDA, Junya, ISHIKAWA, Noriko, NEGORO, Kenji, OHNUKI, Kei, LU, Pu-Ping, COLLIBEE, Scott, KOGANEMARU, Yohei, YAMASAKI, Makoto, MORGAN, Bradley P, KAMIKUBO, Takashi
Year of Publication 21.12.2023
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Year of Publication 21.12.2023
Patent
SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS
ASHCRAFT, Luke W, ZHANG, Hanmo, CHANDRA, Aroop, CHUANG, Chihyuan, JOHNSON, Michael, GONZALEZ, Felix, MUCI - DECEASED, Alex, ROMERO, Antonio, COLLIBEE, Scott, MORGAN, Bradley P, MOEBIUS, David, GARDINA, Jeffrey
Year of Publication 20.10.2022
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Year of Publication 20.10.2022
Patent