Synthesis of DNA-Encoded Macrocyclic Peptides via Nitrile-Aminothiol Click Reaction
Fan, Lijun, Yu, Yang, Jayne, Charles, Frost, John R., Scott, Jack D.
Published in Organic letters (10.11.2023)
Published in Organic letters (10.11.2023)
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MLi-2, a Potent, Selective, and Centrally Active Compound for Exploring the Therapeutic Potential and Safety of LRRK2 Kinase Inhibition
Fell, Matthew J, Mirescu, Christian, Basu, Kallol, Cheewatrakoolpong, Boonlert, DeMong, Duane E, Ellis, J Michael, Hyde, Lynn A, Lin, Yinghui, Markgraf, Carrie G, Mei, Hong, Miller, Michael, Poulet, Frederique M, Scott, Jack D, Smith, Michelle D, Yin, Zhizhang, Zhou, Xiaoping, Parker, Eric M, Kennedy, Matthew E, Morrow, John A
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2015)
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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients
Kennedy, Matthew E, Stamford, Andrew W, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Dockendorf, Marissa F, Egan, Michael, Ereshefsky, Larry, Hodgson, Robert A, Hyde, Lynn A, Jhee, Stanford, Kleijn, Huub J, Kuvelkar, Reshma, Li, Wei, Mattson, Britta A, Mei, Hong, Palcza, John, Scott, Jack D, Tanen, Michael, Troyer, Matthew D, Tseng, Jack L, Stone, Julie A, Parker, Eric M, Forman, Mark S
Published in Science translational medicine (02.11.2016)
Published in Science translational medicine (02.11.2016)
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Discovery of the 3‑Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease
Scott, Jack D, Li, Sarah W, Brunskill, Andrew P. J, Chen, Xia, Cox, Kathleen, Cumming, Jared N, Forman, Mark, Gilbert, Eric J, Hodgson, Robert A, Hyde, Lynn A, Jiang, Qin, Iserloh, Ulrich, Kazakevich, Irina, Kuvelkar, Reshma, Mei, Hong, Meredith, John, Misiaszek, Jeffrey, Orth, Peter, Rossiter, Lana M, Slater, Meagan, Stone, Julie, Strickland, Corey O, Voigt, Johannes H, Wang, Ganfeng, Wang, Hongwu, Wu, Yusheng, Greenlee, William J, Parker, Eric M, Kennedy, Matthew E, Stamford, Andrew W
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
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Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide
Liu, Wentao, Huang, Wei, Lin, Qian, Tsai, Mei-Hsuan, Zhang, Rui, Fan, Lijun, Scott, Jack D., Liu, Guansai, Wan, Jinqiao
Published in Bioorganic & medicinal chemistry (15.05.2021)
Published in Bioorganic & medicinal chemistry (15.05.2021)
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Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues
Bennett, Frank, Huang, Yuhua, Dong, Shuzhi, Jiang, Jinlong, Hunter, David, Zhao, Zhiqiang, Gu, Xin, Scott, Jack D., Tang, Haiqun, Yang, Dexi, Xiao, Li, Scapin, Giovanna, Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Chen, Feifei, Bhatt, Bhavana, Regan, Christopher P., Regan, Hilary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Young, Katherine, Pasternak, Alexander
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
Published in Bioorganic & medicinal chemistry letters (01.12.2024)
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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration
Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
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Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics
Khusial, Richard D., Cioffi, Catherine E., Caltharp, Shelley A., Krasinskas, Alyssa M., Alazraki, Adina, Knight‐Scott, Jack, Cleeton, Rebecca, Castillo‐Leon, Eduardo, Jones, Dean P., Pierpont, Bridget, Caprio, Sonia, Santoro, Nicola, Akil, Ayman, Vos, Miriam B.
Published in Hepatology communications (01.10.2019)
Published in Hepatology communications (01.10.2019)
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Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors
Gulati, Anmol, Yeung, Charles S, Lapointe, Blair, Kattar, Solomon D, Gunaydin, Hakan, Scott, Jack D, Childers, Kaleen K, Methot, Joey L, Simov, Vladimir, Kurukulasuriya, Ravi, Pio, Barbara, Morriello, Greg J, Liu, Ping, Tang, Haiqun, Neelamkavil, Santhosh, Wood, Harold B, Rada, Vanessa L, Ardolino, Michael J, Yan, Xin Cindy, Palte, Rachel, Otte, Karin, Faltus, Robert, Woodhouse, Janice, Hegde, Laxminarayan G, Ciaccio, Paul, Minnihan, Ellen C, DiMauro, Erin F, Fell, Matthew J, Fuller, Peter H, Ellis, J. Michael
Published in MedChemComm (21.07.2021)
Published in MedChemComm (21.07.2021)
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The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease
Hercus, Timothy R., Thomas, Daniel, Guthridge, Mark A., Ekert, Paul G., King-Scott, Jack, Parker, Michael W., Lopez, Angel F.
Published in Blood (13.08.2009)
Published in Blood (13.08.2009)
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Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction
Stamford, Andrew W, Scott, Jack D, Li, Sarah W, Babu, Suresh, Tadesse, Dawit, Hunter, Rachael, Wu, Yusheng, Misiaszek, Jeffrey, Cumming, Jared N, Gilbert, Eric J, Huang, Chunli, McKittrick, Brian A, Hong, Liwu, Guo, Tao, Zhu, Zhaoning, Strickland, Corey, Orth, Peter, Voigt, Johannes H, Kennedy, Matthew E, Chen, Xia, Kuvelkar, Reshma, Hodgson, Robert, Hyde, Lynn A, Cox, Kathleen, Favreau, Leonard, Parker, Eric M, Greenlee, William J
Published in ACS medicinal chemistry letters (08.11.2012)
Published in ACS medicinal chemistry letters (08.11.2012)
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Characterization of a novel vasopressin V1b receptor antagonist, V1B-30N, in animal models of anxiety-like and depression-like behavior
Hodgson, Robert A., Mullins, Deborra, Lu, Sherry X., Guzzi, Mario, Zhang, Xiaoping, Bleickardt, Carina J., Scott, Jack D., Miller, Michael W., Stamford, Andrew W., Parker, Eric M., Varty, Geoffrey B.
Published in European journal of pharmacology (05.05.2014)
Published in European journal of pharmacology (05.05.2014)
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Validation of the Brief Jail Mental Health Screen
Steadman, Henry J, Scott, Jack E, Osher, Fred, Agnese, Tara K, Robbins, Pamela Clark
Published in Psychiatric services (Washington, D.C.) (01.07.2005)
Published in Psychiatric services (Washington, D.C.) (01.07.2005)
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Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling
Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dottore, Mara, McClure, Barbara J., Dhagat, Urmi, Taing, Houng, Gorman, Michael A., King-Scott, Jack, Lopez, Angel F., Parker, Michael W.
Published in Structure (London) (02.08.2016)
Published in Structure (London) (02.08.2016)
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