A General Amino Acid Synthesis Enabled by Innate Radical Cross‐Coupling
Ni, Shengyang, Garrido‐Castro, Alberto F., Merchant, Rohan R., de Gruyter, Justine N., Schmitt, Daniel C., Mousseau, James J., Gallego, Gary M., Yang, Shouliang, Collins, Michael R., Qiao, Jennifer X., Yeung, Kap‐Sun, Langley, David R., Poss, Michael A., Scola, Paul M., Qin, Tian, Baran, Phil S.
Published in Angewandte Chemie International Edition (26.10.2018)
Published in Angewandte Chemie International Edition (26.10.2018)
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Ligand-Enabled β‑C–H Arylation of α‑Amino Acids Using a Simple and Practical Auxiliary
Chen, Gang, Shigenari, Toshihiko, Jain, Pankaj, Zhang, Zhipeng, Jin, Zhong, He, Jian, Li, Suhua, Mapelli, Claudio, Miller, Michael M, Poss, Michael A, Scola, Paul M, Yeung, Kap-Sun, Yu, Jin-Quan
Published in Journal of the American Chemical Society (11.03.2015)
Published in Journal of the American Chemical Society (11.03.2015)
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Synthetic studies toward a simplified eleuthoside core
Scola, Paul M., Kadow, John F., Langley, David, Vyas, Dolatrai
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides
Strauss, Michael J., Greaves, Megan E., Kim, Seoung‐Tae, Teijaro, Christiana N., Schmidt, Michael A., Scola, Paul M., Buchwald, Stephen L.
Published in Angewandte Chemie International Edition (06.05.2024)
Published in Angewandte Chemie International Edition (06.05.2024)
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Challenges with the Synthesis of a Macrocyclic Thioether Peptide: From Milligram to Multigram Using Solid Phase Peptide Synthesis (SPPS)
Kempson, James, Zhao, Rulin, Pawluczyk, Joseph, Wang, Bei, Zhang, Huiping, Hou, Xiaoping, Allen, Martin P., Wu, Dauh-Rurng, Li, Peng, Yip, Shiuhang, Smith, Aaron, Traeger, Sarah C., Huang, Stella, Cutrone, Jingfang, Mukherjee, Subha, Sfouggatakis, Chris, Poss, Michael, Scola, Paul M., Meanwell, Nicholas A., Carter, Percy H., Mathur, Arvind
Published in Journal of organic chemistry (17.05.2024)
Published in Journal of organic chemistry (17.05.2024)
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Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O–H Activation and Lewis Acid-Catalyzed Fluoride Shuttling
Moon, Hye Won, Lavagnino, Marissa N., Lim, Soohyun, Palkowitz, Maximilian D., Mandler, Michael D., Beutner, Gregory L., Drance, Myles J., Lipshultz, Jeffrey M., Scola, Paul M., Radosevich, Alexander T.
Published in Journal of the American Chemical Society (18.10.2023)
Published in Journal of the American Chemical Society (18.10.2023)
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Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O‑Arylation of Amino Alcohols
Strauss, Michael J., Liu, Kaylee X., Greaves, Megan E., Dahl, Jakob C., Kim, Seoung-Tae, Wu, Yong-Jin, Schmidt, Michael A., Scola, Paul M., Buchwald, Stephen L.
Published in Journal of the American Chemical Society (10.07.2024)
Published in Journal of the American Chemical Society (10.07.2024)
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Preclinical Profile and Characterization of the Hepatitis C Virus NS3 Protease Inhibitor Asunaprevir (BMS-650032)
MCPHEE, Fiona, SHEAFFER, Amy K, CHAOQUN CHEN, LEE, Min S, MOSURE, Kathy, SUN, Li-Qiang, SINZ, Michael, MEANWELL, Nicholas A, COLONNO, Richard J, KNIPE, Jay, SCOLA, Paul, FRIBORG, Jacques, HERNANDEZ, Dennis, FALK, Paul, GUANGZHI ZHAI, LEVINE, Steven, CHANIEWSKI, Susan, FEI YU, BARRY, Diana
Published in Antimicrobial Agents and Chemotherapy (01.10.2012)
Published in Antimicrobial Agents and Chemotherapy (01.10.2012)
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The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement
Donnelly, David J., Kim, Joonyoung, Tran, Tritin, Scola, Paul M., Tenney, Daniel, Pena, Adrienne, Petrone, Thomas, Zhang, Yunhui, Boy, Kenneth M., Poss, Michael A., Cole, Erin L., Soars, Matthew G., Johnson, Benjamin M., Cohen, Daniel, Batalla, Daniel, Chow, Patrick L., Shorts, Andrea Olga, Du, Shuyan, Meanwell, Nicholas A., Bonacorsi, Samuel J.
Published in European journal of nuclear medicine and molecular imaging (01.03.2024)
Published in European journal of nuclear medicine and molecular imaging (01.03.2024)
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Discovery and Early Clinical Evaluation of BMS-605339, a Potent and Orally Efficacious Tripeptidic Acylsulfonamide NS3 Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
Scola, Paul M., Wang, Alan Xiangdong, Good, Andrew C., Sun, Li-Qiang, Combrink, Keith D., Campbell, Jeffrey A., Chen, Jie, Tu, Yong, Sin, Ny, Venables, Brian L., Sit, Sing-Yuen, Chen, Yan, Cocuzza, Anthony, Bilder, Donna M., D’Andrea, Stanley, Zheng, Barbara, Hewawasam, Piyasena, Ding, Min, Thuring, Jan, Li, Jianqing, Hernandez, Dennis, Yu, Fei, Falk, Paul, Zhai, Guangzhi, Sheaffer, Amy K., Chen, Chaoqun, Lee, Min S., Barry, Diana, Knipe, Jay O., Li, Wenying, Han, Yong-Hae, Jenkins, Susan, Gesenberg, Christoph, Gao, Qi, Sinz, Michael W., Santone, Kenneth S., Zvyaga, Tatyana, Rajamani, Ramkumar, Klei, Herbert E., Colonno, Richard J., Grasela, Dennis M., Hughes, Eric, Chien, Caly, Adams, Stephen, Levesque, Paul C., Li, Danshi, Zhu, Jialong, Meanwell, Nicholas A., McPhee, Fiona
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer
Kim, Joonyoung, Donnelly, David J., Tran, Tritin, Pena, Adrienne, Shorts, Andrea Olga, Petrone, Thomas V., Zhang, Yunhui, Boy, Kenneth M., Scola, Paul M., Tenney, Daniel J., Poss, Michael A., Soars, Matthew G., Bonacorsi, Samuel J., Cole, Erin L., Grootendorst, Diederik J., Chow, Patrick L., Meanwell, Nicholas A., Du, Shuyan
Published in Molecular imaging and biology (01.04.2024)
Published in Molecular imaging and biology (01.04.2024)
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Potent Inhibitors of Hepatitis C Virus NS3 Protease: Employment of a Difluoromethyl Group as a Hydrogen-Bond Donor
Zheng, Barbara, D’Andrea, Stanley V, Sun, Li-Qiang, Wang, Alan Xiangdong, Chen, Yan, Hrnciar, Peter, Friborg, Jacques, Falk, Paul, Hernandez, Dennis, Yu, Fei, Sheaffer, Amy K, Knipe, Jay O, Mosure, Kathy, Rajamani, Ramkumar, Good, Andrew C, Kish, Kevin, Tredup, Jeffrey, Klei, Herbert E, Paruchuri, Manjula, Ng, Alicia, Gao, Qi, Rampulla, Richard A, Mathur, Arvind, Meanwell, Nicholas A, McPhee, Fiona, Scola, Paul M
Published in ACS medicinal chemistry letters (08.02.2018)
Published in ACS medicinal chemistry letters (08.02.2018)
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P3-P4 ureas and reverse carbamates as potent HCV NS3 protease inhibitors: Effective transposition of the P4 hydrogen bond donor
Venables, Brian L., Sin, Ny, Wang, Alan Xiangdong, Sun, Li-Qiang, Tu, Yong, Hernandez, Dennis, Sheaffer, Amy, Lee, Min, Dunaj, Cindy, Zhai, Guangzhi, Barry, Diana, Friborg, Jacques, Yu, Fei, Knipe, Jay, Sandquist, Jason, Falk, Paul, Parker, Dawn, Good, Andrew C., Rajamani, Ramkumar, McPhee, Fiona, Meanwell, Nicholas A., Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
Published in Bioorganic & medicinal chemistry letters (01.06.2018)
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Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists
Hu, Shuanghua, Huang, Yazhong, Wu, Yong-Jin, He, Huan, Grant-Young, Katherine A., Bertekap, Robert L., Whiterock, Valerie, Brassil, Patrick, Lentz, Kimberley, Sivaprakasam, Prasanna, Langley, David R., Westphal, Ryan S., Scola, Paul M.
Published in Bioorganic & medicinal chemistry (01.03.2014)
Published in Bioorganic & medicinal chemistry (01.03.2014)
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Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor
Mosure, Kathleen W., Knipe, Jay O., Browning, Marc, Arora, Vinod, Shu, Yue-Zhong, Phillip, Thomas, Mcphee, Fiona, Scola, Paul, Balakrishnan, Anand, Soars, Matthew G., Santone, Kenneth, Sinz, Michael
Published in Journal of pharmaceutical sciences (01.09.2015)
Published in Journal of pharmaceutical sciences (01.09.2015)
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Room‐Temperature Copper‐Catalyzed Etherification of Aryl Bromides
Strauss, Michael J., Greaves, Megan E., Kim, Seoung‐Tae, Teijaro, Christiana N., Schmidt, Michael A., Scola, Paul M., Buchwald, Stephen L.
Published in Angewandte Chemie (06.05.2024)
Published in Angewandte Chemie (06.05.2024)
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The discovery and optimization of naphthalene-linked P2-P4 Macrocycles as inhibitors of HCV NS3 protease
Bowsher, Michael, Hiebert, Sheldon, Li, Rongti, Wang, Alan X., Friborg, Jacques, Yu, Fei, Hernandez, Dennis, Wang, Ying-Kai, Klei, Herbert, Rajamani, Ramkumar, Mosure, Kathy, Knipe, Jay O., Meanwell, Nicholas A., McPhee, Fiona, Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
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Journal Article
Single- and Multiple-Ascending-Dose Studies of the NS3 Protease Inhibitor Asunaprevir in Subjects with or without Chronic Hepatitis C
PASQUINELLI, Claudio, MCPHEE, Fiona, SCOLA, Paul, MARBURY, Thomas, LAWITZ, Eric, GOLDWATER, Ronald, RODRIGUEZ-TORRES, Maribel, DEMICCO, Michael, WRIGHT, David, CHARLTON, Michael, KRAFT, Walter K, LOPEZ-TALAVERA, Juan-Carlos, ELEY, Timothy, GRASELA, Dennis M, VILLEGAS, Criselda, SANDY, Katrina, SHERIDAN, Pamela, PERSSON, Anna, HUANG, Shu-Pang, HERNANDEZ, Dennis, SHEAFFER, Amy K
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
Published in Antimicrobial Agents and Chemotherapy (01.04.2012)
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Functionalized triazines as potent HCV entry inhibitors
Mull, Eric S., Sun, Li-Qiang, Zhao, Qian, Eggers, Betsy, Pokornowski, Kevin, Zhai, Guangzhi, Rajamani, Ramkumar, Jenkins, Susan, Kramer, Melissa, Wang, Ying-Kai, Fang, Hua, Tenney, Daniel, Baldick, Carl J., Cockett, Mark I., Meanwell, Nicholas A., Scola, Paul M.
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
Published in Bioorganic & medicinal chemistry letters (15.02.2017)
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