Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
Bywater, Megan J., Poortinga, Gretchen, Sanij, Elaine, Hein, Nadine, Peck, Abigail, Cullinane, Carleen, Wall, Meaghan, Cluse, Leonie, Drygin, Denis, Anderes, Kenna, Huser, Nanni, Proffitt, Chris, Bliesath, Joshua, Haddach, Mustapha, Schwaebe, Michael K., Ryckman, David M., Rice, William G., Schmitt, Clemens, Lowe, Scott W., Johnstone, Ricky W., Pearson, Richard B., McArthur, Grant A., Hannan, Ross D.
Published in Cancer cell (10.07.2012)
Published in Cancer cell (10.07.2012)
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CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy
Siddiqui-Jain, Adam, Drygin, Denis, Streiner, Nicole, Chua, Peter, Pierre, Fabrice, O'Brien, Sean E, Bliesath, Josh, Omori, Mayuko, Huser, Nanni, Ho, Caroline, Proffitt, Chris, Schwaebe, Michael K, Ryckman, David M, Rice, William G, Anderes, Kenna
Published in Cancer research (Chicago, Ill.) (15.12.2010)
Published in Cancer research (Chicago, Ill.) (15.12.2010)
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Journal Article
Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
DRYGIN, Denis, LIN, Amy, STREINER, Nicole, QUIN, Jaclyn E, SANIJ, Elaine, BYWATE, Megan J, HANNAN, Ross D, RYCKMAN, David, ANDERES, Kenna, RICE, William G, BLIESATH, Josh, HO, Caroline B, O'BRIEN, Sean E, PROFFITT, Chris, OMORI, Mayuko, HADDACH, Mustapha, SCHWAEBE, Michael K, SIDDIQUI-JAIN, Adam
Published in Cancer research (Chicago, Ill.) (15.02.2011)
Published in Cancer research (Chicago, Ill.) (15.02.2011)
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Journal Article
Discovery and SAR of 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer
Pierre, Fabrice, Chua, Peter C, O’Brien, Sean E, Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K, Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P, Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Anderes, Kenna, Bliesath, Josh, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Trent, Katy, Rice, William G, Ryckman, David M
Published in Journal of medicinal chemistry (27.01.2011)
Published in Journal of medicinal chemistry (27.01.2011)
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Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
DRYGIN, Denis, SIDDIQUI-JAIN, Adam, LIM, John K. C, VON HOFF, Daniel, ANDERES, Kenna, RICE, William G, O'BRIEN, Sean, SCHWAEBE, Michael, LIN, Amy, BLIESATH, Josh, HO, Caroline B, PROFFITT, Chris, TRENT, Katy, WHITTEN, Jeffrey P
Published in Cancer research (Chicago, Ill.) (01.10.2009)
Published in Cancer research (Chicago, Ill.) (01.10.2009)
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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
Pierre, Fabrice, Chua, Peter C., O’Brien, Sean E., Siddiqui-Jain, Adam, Bourbon, Pauline, Haddach, Mustapha, Michaux, Jerome, Nagasawa, Johnny, Schwaebe, Michael K., Stefan, Eric, Vialettes, Anne, Whitten, Jeffrey P., Chen, Ta Kung, Darjania, Levan, Stansfield, Ryan, Bliesath, Joshua, Drygin, Denis, Ho, Caroline, Omori, May, Proffitt, Chris, Streiner, Nicole, Rice, William G., Ryckman, David M., Anderes, Kenna
Published in Molecular and cellular biochemistry (01.10.2011)
Published in Molecular and cellular biochemistry (01.10.2011)
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Journal Article
Discovery of CX-5461, the First Direct and Selective Inhibitor of RNA Polymerase I, for Cancer Therapeutics
Haddach, Mustapha, Schwaebe, Michael K, Michaux, Jerome, Nagasawa, Johnny, O'Brien, Sean E, Whitten, Jeffrey P, Pierre, Fabrice, Kerdoncuff, Pauline, Darjania, Levan, Stansfield, Ryan, Drygin, Denis, Anderes, Kenna, Proffitt, Chris, Bliesath, Josh, Siddiqui-Jain, Adam, Omori, May, Huser, Nanni, Rice, William G, Ryckman, David M
Published in ACS medicinal chemistry letters (12.07.2012)
Published in ACS medicinal chemistry letters (12.07.2012)
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Journal Article
Discovery of CX-6258. A Potent, Selective, and Orally Efficacious pan-Pim Kinases Inhibitor
Haddach, Mustapha, Michaux, Jerome, Schwaebe, Michael K, Pierre, Fabrice, O’Brien, Sean E, Borsan, Cosmin, Tran, Joe, Raffaele, Nicholas, Ravula, Suchitra, Drygin, Denis, Siddiqui-Jain, Adam, Darjania, Levan, Stansfield, Ryan, Proffitt, Chris, Macalino, Diwata, Streiner, Nicole, Bliesath, Joshua, Omori, May, Whitten, Jeffrey P, Anderes, Kenna, Rice, William G, Ryckman, David M
Published in ACS medicinal chemistry letters (09.02.2012)
Published in ACS medicinal chemistry letters (09.02.2012)
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Journal Article
A Facile Synthesis of 5-Halopyrimidine-4-Carboxylic Acid Esters via a Minisci Reaction
Regan, Collin F., Pierre, Fabrice, Schwaebe, Michael K., Haddach, Mustapha, Jung, Michael E., Ryckman, David M.
Published in Synlett (01.02.2012)
Published in Synlett (01.02.2012)
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Journal Article
Novel potent pyrimido[4,5- c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties
Pierre, Fabrice, O’Brien, Sean E., Haddach, Mustapha, Bourbon, Pauline, Schwaebe, Michael K., Stefan, Eric, Darjania, Levan, Stansfield, Ryan, Ho, Caroline, Siddiqui-Jain, Adam, Streiner, Nicole, Rice, William G., Anderes, Kenna, Ryckman, David M.
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
Published in Bioorganic & medicinal chemistry letters (15.03.2011)
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Journal Article
Synthesis and SAR of inhibitors of protein kinase CK2: Novel tricyclic quinoline analogs
Haddach, Mustapha, Pierre, Fabrice, Regan, Collin F., Borsan, Cosmin, Michaux, Jerome, Stefan, Eric, Kerdoncuff, Pauline, Schwaebe, Michael K., Chua, Peter C., Siddiqui-Jain, Adam, Macalino, Diwata, Drygin, Denis, O’Brien, Sean E., Rice, William G., Ryckman, David M.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core
Dyck, Brian, Grigoriadis, Dimitri E, Gross, Raymond S, Guo, Zhiqiang, Haddach, Mustapha, Marinkovic, Dragan, McCarthy, James R, Moorjani, Manisha, Regan, Collin F, Saunders, John, Schwaebe, Michael K, Szabo, Tomas, Williams, John P, Zhang, Xiaohu, Bozigian, Haig, Chen, Ta Kung
Published in Journal of medicinal chemistry (16.06.2005)
Published in Journal of medicinal chemistry (16.06.2005)
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Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity
Fellows, Ingrid M, Schwaebe, Michael, Dexheimer, Thomas S, Vankayalapati, Hariprasad, Gleason-Guzman, Mary, Whitten, Jeffrey P, Hurley, Laurence H
Published in Molecular cancer therapeutics (01.11.2005)
Published in Molecular cancer therapeutics (01.11.2005)
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Journal Article
Atom Transfer Reactions of TMM Diyls Directed toward the Synthesis of Rudmollin
Carroll, Georgia Law, Allan, Amy Kim, Schwaebe, Michael K, Little, R. Daniel
Published in Organic letters (10.08.2000)
Published in Organic letters (10.08.2000)
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Journal Article
Total synthesis of psorospermin
Schwaebe, Michael K., Moran, Terence J., Whitten, Jeffrey P.
Published in Tetrahedron letters (31.01.2005)
Published in Tetrahedron letters (31.01.2005)
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