Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase
Schulze, Volker K, Klar, Ulrich, Kosemund, Dirk, Wengner, Antje M, Siemeister, Gerhard, Stöckigt, Detlef, Neuhaus, Roland, Lienau, Philip, Bader, Benjamin, Prechtl, Stefan, Holton, Simon J, Briem, Hans, Marquardt, Tobias, Schirok, Hartmut, Jautelat, Rolf, Bohlmann, Rolf, Nguyen, Duy, Fernández-Montalván, Amaury E, Bömer, Ulf, Eberspaecher, Uwe, Brüning, Michael, Döhr, Olaf, Raschke, Marian, Kreft, Bertolt, Mumberg, Dominik, Ziegelbauer, Karl, Brands, Michael, von Nussbaum, Franz, Koppitz, Marcus
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Journal Article
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Lemos, Clara, Schulze, Volker K., Baumgart, Simon J., Nevedomskaya, Ekaterina, Heinrich, Tobias, Lefranc, Julien, Bader, Benjamin, Christ, Clara D., Briem, Hans, Kuhnke, Lara P., Holton, Simon J., Bömer, Ulf, Lienau, Philip, von Nussbaum, Franz, Nising, Carl F., Bauser, Marcus, Hägebarth, Andrea, Mumberg, Dominik, Haendler, Bernard
Published in Cellular oncology (Dordrecht) (01.06.2021)
Published in Cellular oncology (Dordrecht) (01.06.2021)
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Journal Article
Abstract 5873: BAY-3827, a selective inhibitor of AMPK for the evaluation of the role of AMPK in Myc-dependent tumors
Lemos, Clara, Schulze, Volker K., Bader, Benjamin, Christ, Clara D., Briem, Hans, Politz, Oliver, Prinz, Florian, Holton, Simon, Heinrich, Tobias, Lefranc, Julien, Lienau, Philip, Scholz, Arne, Nussbaum, Franz von, Nising, Carl Friedrich, Mumberg, Dominik, Bauser, Marcus, Hägebarth, Andrea
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 3588: Discovery of potent and selective CSNK1A1 inhibitors for solid tumor therapy
Corsello, Steven M., Zhang, Huajia, Rupaimoole, Rajesha, Schulze, Volker K., Lemos, Clara, Handing, Kasia B., Orsi, Douglas L., Shekhar, Mrinal, Sack, Ulrike, Christian, Sven, Bone, Wilhelm, Humeidi, Ranad, Colgan, William, Hoyt, Stephanie, Cherniack, Andrew, Schroder, Jens, Kaulfuss, Stefan, Brzezinka, Krzysztof, von Ahsen, Oliver, Mengel, Anne, Hillig, Roman C., Suelzle, Detlev, Mortier, Jeremie, Harrington, Caitlin, Nagari, Rohith, Wierzbinska, Justyna, Chiang, Derek, Beckmann, Georg, Olive, Meagan, Udeshi, Namrata, Apffel, Annie, Carr, Steven, Lienau, Philip, Lechner, Christian, Boemer, Ulf, Caliman, Alisha, McKinney, David, Wagner, Florence, Mumberg, Dominik, Bauser, Marcus, Haegebarth, Andrea, Eis, Knut, Eheim, Ashley, Golub, Todd R.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Asymmetric synthesis of (+)-loline
Blakemore, PR, Schulze, VK, White, JD
Published in Chemical communications (Cambridge, England) (01.01.2000)
Published in Chemical communications (Cambridge, England) (01.01.2000)
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Journal Article
SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS
SCHULZE Volker K, STÖCKIGT Detlef, SCHALL Andreas, BRIEM Hans, WENGNER Antje Margret, LIENAU Philip, SIEMEISTER Gerhard
Year of Publication 15.09.2016
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Year of Publication 15.09.2016
Patent
SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS
LIENAU, PHILIP, SIEMEISTER, GERHARD, STÖCKIGT, DETLEF, SCHULZE, VOLKER K, BRIEM, HANS, SCHALL, ANDREAS, WENGNER, ANTJE MARGRET
Year of Publication 13.04.2016
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Year of Publication 13.04.2016
Patent
SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS
LIENAU, PHILIP, SIEMEISTER, GERHARD, SCHULZE, VOLKER K, BRIEM, HANS, STOCKIGT, DETLEF, SCHALL, ANDREAS, WENGNER, ANTJE MARGRET
Year of Publication 11.12.2014
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Year of Publication 11.12.2014
Patent
SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS
LIENAU, PHILIP, SIEMEISTER, GERHARD, STÖCKIGT, DETLEF, SCHULZE, VOLKER K, BRIEM, HANS, SCHALL, ANDREAS, WENGNER, ANTJE MARGRET
Year of Publication 11.12.2014
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Year of Publication 11.12.2014
Patent
SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS MPS-1
STCKIGT, Detlef, WENGNER, Antje Margret, LIENAU, Philip, SIEMEISTER, Gerhard, SCHULZE, Volker K, BRIEM, Hans, SCHALL, Andreas
Year of Publication 14.07.2017
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Year of Publication 14.07.2017
Patent
Substituted triazolopyridines having activity as MPS-1 inhibitors
LIENAU PHILIP, WENGNER ANTJE MARGRET, SIEMEISTER GERHARD, SCHALL ANDREAS, BRIEM HANS, STOCKIGT DETLEF, SCHULZE VOLKER K
Year of Publication 23.03.2016
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Year of Publication 23.03.2016
Patent
Metasubstituted thiazolidinones, their manufacture and use as a drug
EBERSPAECHER UWE, KOSEMUND DIRK, SIEMEISTER GERHARD, HESS-STUMPP HOLGER, EIS KNUT, WORTMANN LARS, BRITTAIN DOMINIC E, SCHULZE VOLKER K, PRIEN OLAF, ISLAM IMADUL
Year of Publication 18.01.2007
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Year of Publication 18.01.2007
Patent